Preparation and characterization of Levan composite film incorporating vanillin for use as a potential edible coating for peony seed oil.

The study prepared an edible packaging material for peony seed oil by adding natural antioxidant vanillin to a microbial Levan composite film. The presence of highly branched Levan, containing polyhydroxyl groups, significantly enhanced the maximum tension (26.57 N), tensile strength (36.

A composite film of oxidized levan crosslinked with gelatin: strong hydrophobic and mechanical properties and effective preservation of fresh Mozzarella cheese.

The fructosan levan was synthesized in vitro using a recombinant levansucrase. The levan was oxidized with sodium periodate to prepare oxidized levan (OLevan) with three oxidation degrees. OLevan, gelatin (Gel), and gallic acid (GA) were used to prepare the composite films by the method of plate pouring.

Mechanisms of levan in ameliorating hyperuricemia: Insight into levan on serum metabolites, gut microbiota, and function in hyperuricemia rats.

This study aims to investigate the effects of levan on the progression of hyperuricemia (HUA) rats and elucidate its underlying mechanisms. After levan intervention, both low and high-dose groups exhibited a significant decrease in serum uric acid (UA) levels, reaching 71.0 % and 77.

Synthesis and Biological Evaluation of Isoaurone Derivatives as Anti-inflammatory Agents.

Twenty-eight isoaurone derivatives with 1,2,4-triazole moieties were synthesized using a fragment-based design strategy, and their anti-inflammatory activity was investigated. The anti-inflammatory effect of the most active derivative, 14e (41.82 %), was dose-dependent and higher than the values for celecoxib (31.

Circular RNA RRM2 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miR-142-5p to increase NRG1 expression.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition worldwide, demanding further investigation into its pathogenesis. Circular RNAs (circRNAs) are emerging as pivotal regulators in MASLD processes, yet their pathological implications in MASLD remain poorly understood. This study focused on elucidating the role of circular RNA ribonucleotide reductase subunit M2 (circRRM2) in MASLD progression.

Potentially inappropriate prescribing among older adults with hypertension in China: prevalence and related comorbidities across different outpatient settings.

Purpose: Potentially inappropriate prescribing (PIP) is commonly encountered in older adults; yet, there is limited information on the occurrence of PIP among older adults with hypertension. This study aims to determine and compare the prevalence of PIP and its association with comorbidities in older adult outpatients with hypertension across hospitals and community health centers (CHCs).

Methods: This 3-year (2015-2017) repeated cross-sectional study used electronic medical records from Shenzhen, China, involving 62 hospitals and 678 primary medical institutions.

Transcriptome Analysis Reveals the Role of Sucrose in the Production of L3 Exopolysaccharide.

() is a species of lactic acid bacteria (LAB) mostly studied according to its application in food fermentation. Previously, L3 was isolated by our laboratory and possessed the capability of high exopolysaccharide (EPS) yield during sucrose-added fermentation. However, the understanding of sucrose promoting EPS production is still limited.

Evaluate the Structural and Physicochemical Properties of Exopolysaccharides Produced by Isolated from Locally Sourced Vegetables.

In this study, a () strain DT1 capable of producing exopolysaccharides (EPS) was isolated from dried cabbages of Tianjin, a local fermented vegetable product. Three distinct polysaccharide fractions were isolated from the fermentation broth of DT1, namely, DT1-0, DT1-2, and DT1-5. The structural composition and properties of these fractions were investigated.

Exploring Mechanisms of Antifungal Lipopeptide Iturin A from Bacillus against .

The control of () is of great significance for the agricultural economy and food safety. In this study, the antifungal effect and mechanism of iturin A from (CGMCC No. 8473) against (ATCC 16404) were investigated using biochemical analyses and proteomics.

Insight into the inhibitory activity and mechanism of bovine cathelicidin BMAP 27 against Salmonella Typhimurium.

This study synthesized an antimicrobial peptide based on the bovine cathelicidin BMAP 27 sequence. It was found to have a broad spectrum of antibacterial activity, with exceptionally high activity against Salmonella. However, the antibacterial mechanism of BMAP 27 against Salmonella remains unclear.

Effect and mechanism of total ginsenosides repairing SDS‑induced enteritis model based on MAPK pathway.

Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal disease that seriously endangers human and animal health. Although the etiology of IBD is complex and the pathogenesis is not well understood, studies have found that genetic predisposition, diet and intestinal flora disorders are the main risk factors for IBD. The potential biological mechanism of total ginsenosides (TGGR) in the treatment of IBD remains to be elucidated.

Elevated serum lead and cadmium levels associated with increased risk of dyslipidemia in children aged 6 to 9 years in Shenzhen, China.

Exposure to heavy metals can influence on metabolism, but studies have not fully evaluated young children. We investigated the association between levels of serum lead (Pb), cadmium (Cd), chromium (Cr), and arsenic (As) and risk of dyslipidemia in children. A total of 4513 children aged 6 to 9 years at 19 primary schools in Shenzhen were enrolled.

Simulated Digestion and Fecal Fermentation Behaviors of Levan and Its Impacts on the Gut Microbiota.

Levan is a microbial fructan widely explored in various fields owing to its excellent physical and biochemical properties. However, little is known about its digestion and fermentation characteristics in vitro. This study evaluated the potential prebiotic properties of levan obtained by enzymatic synthesis.

Levan-chitosan blend films: Preparation, structural, physical properties and application in pork packaging.

Conventional fossil fuel-based packaging materials often brings of food safety and serious environmental pollution. It is significant to develop an environmentally-friendly packaging material. In this work, a levan-chitosan (LE/CS) blend film was fabricated via the solution casting method.

Structural characterization of levan synthesized by a recombinant levansucrase and its application as yogurt stabilizers.

Levan, a class of fructan with complex structure, has been found to have potential as a prebiotic. In this study, the polysaccharide was produced by in vitro catalysis (Cata-lev), structural analysis proved it was levan that possessed a branching degree of about 15% and molecular weight of 2.54 × 10 Da.

Metagenomics Reveals the Diversity and Taxonomy of Carbohydrate-Active Enzymes and Antibiotic Resistance Genes in Suancai Bacterial Communities.

Suancai, as a traditional fermented food in China with reputed health benefits, has piqued global attention for many years. In some circumstances, the microbial-driven fermentation may confer health (e.g.

Antimicrobial Mechanisms of Enterocin CHQS Against Candida albicans.

Candida albicans is the most common fungal pathogen in hospital-acquired infections, which is extremely harmful to health. The increasing fungal infections is requiring the rapid development of novel antifungal agents. In this study, the antimicrobial activity of CHQS, an enterocin isolated from Enterococcus faecalis TG2 against C.

Dihydrotriazine derivatives display high anticancer activity and inducing apoptosis, ROS, and autophagy.

A series of dihydrotriazine derivatives bearing 5-aryloxypyrazole moieties were designed, and their anticancer activities against three human cancer cell lines (SGC-7901, HepG-2 and MCF-7) and one non-cancer cell line (LO2) were explored using the MTT assay in vitro. Most of the compounds exhibited potent antiproliferative activities against the three cancer cell lines, with compound 10e (IC = 2.12 µM) exhibiting the most potent antiproliferative activity against HepG-2 cells.

Pilot-scale production of exopolysaccharide from Leuconostoc pseudomesenteroides XG5 and its application in set yogurt.

Exopolysaccharide from Leuconostoc pseudomesenteroides XG5 (XG5 EPS) is a linear dextran that is built by glucose units via α-1,6 glycosidic bond. The primary objective of this study was to investigate the yield of XG5 EPS and its application in set yogurt. In laboratory scale, the culture conditions of XG5 EPS production were optimized using the L9 (3) orthogonal test.

Effects of L-theanine on intestinal morphology, barrier function, and MAPK signaling pathways in diquat-challenged piglets.

This study aimed to explore the protective effects of L-theanine supplementation on the diquat-challenged weaned piglets. A total of 160 weaned piglets were randomly divided into 4 groups using a 2 × 2 two-factor design, there were 4 replicates per group and 10 pigs per replicate. Piglets were fed diets (with 1000 mg/kg L-theanine addition or not), then challenged with diquat or saline on day 7.

Biosorption of Pb and Zn by Ca-alginate immobilized and free extracellular polysaccharides produced by Leuconostoc citreum B-2.

Aims: Heavy metal pollution seriously threatens human health and ecological environment. Due to high efficiency and excellent development prospect, adsorption technology has attracted worldwide attention. It is significant to develop renewable adsorbents with excellent adsorption performance.

Long-term drench of exopolysaccharide from Leuconostoc pseudomesenteroides XG5 protects against type 1 diabetes of NOD mice via stimulating GLP-1 secretion.

Background: Type 1 diabetes is an autoimmune disease that results in the specific destruction of insulin-producing beta cells in the pancreas. The aim of this study was to investigate the mechanism of exopolysaccharide from Leuconostoc pseudomesenteroides XG5 (XG5 EPS) against type 1 diabetes.

Results: Long-term drench of XG5 EPS delayed the onset of autoimmune diabetes and had fewer islets with high-grade infiltration (an insulitis score of 3 or 4) than untreated NOD mice.

Physical and antibacterial properties of bacterial cellulose films supplemented with cell-free supernatant enterocin-producing Enterococcus faecium TJUQ1.

In this study, a composite film was prepared with bacterial cellulose (BC) of Gluconacetobacter xylinus and cell-free supernatant (CFS) of Enterococcus faecium TJUQ1, which was named BC-E. The optimum conditions for the preparation of the composite film with a minimal antibacterial activity were the soak of BC in 80 AU/mL CFS for 6 h. By scanning electron microscope observation, the surface network structure of BC-E was denser than that of BC.

Metagenomic insights into Chinese northeast suancai: Predominance and diversity of genes associated with nitrogen metabolism in traditional household suancai fermentation.

Chinese northeast suancai represents a typical and valuable food product that has been handed down by traditional household procedures over centuries. Nitrite is formed and accumulated during the suancai fermentation process and commonly causes food safety problems. The biogeochemical cycle of nitrite may provide a reference and guidance for the enzymatic degradation of nitrite in fermented food.