EMF1 functions as a 3D chromatin modulator in Arabidopsis.

It is well known that genome organizers, like mammalian CCCTC-binding factor (CTCF) or Drosophila architectural proteins CP190 and BEAF-32, contribute to the three-dimensional (3D) organization of the genome and ensure normal gene transcription. However, bona fide genome organizers have not been identified in plants. Here, we show that EMBRYONIC FLOWER1 (EMF1) functions as a genome modulator in Arabidopsis.

ZmELP1, an Elongator complex subunit, is required for the maintenance of histone acetylation and RNA Pol II phosphorylation in maize kernels.

The Elongator complex was originally identified as an interactor of hyperphosphorylated RNA polymerase II (RNAPII) in yeast and has histone acetyltransferase (HAT) activity. However, the genome-wide regulatory roles of Elongator on transcriptional elongation and histone acetylation remain unclear. We characterized a maize miniature seed mutant, mn7 and map-based cloning revealed that Mn7 encodes one of the subunits of the Elongator complex, ZmELP1.

Linkage of Blood MALT1 with CD4+ T Cell Subset, Inflammation, Lipid, and Its Potency as a Biomarker for Predicting Major Adverse Cardiovascular Events in Coronary Heart Disease Patients.

Objective: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) promotes CD4 T cell differentiation, vascular inflammation, and atherogenesis to engage in coronary heart disease (CHD) progression. This study intended to explore the correlation of blood MALT1 with clinical characteristics, CD4 T cell subset and prognosis in CHD patients.

Methods: MALT1 in peripheral blood mononuclear cells of 258 CHD patients and 50 healthy controls (HCs) was determined by RT-qPCR.

Decomposition-Coordination of Double-Layer MPC for Constrained Systems.

Large-scale industrial processes usually adopt centralized control and optimization methods. However, with the growth of the scale of industrial processes leading to increasing computational complexity, the online optimization capability of the double-layer model predictive control algorithm is challenged, exacerbating the difficulty of the widespread implementation of this algorithm in the industry. This paper proposes a distributed double-layer model predictive control algorithm based on dual decomposition for multivariate constrained systems to reduce the computational complexity of process control.

HEAT SHOCK PROTEIN 90.6 interacts with carbon and nitrogen metabolism components during seed development.

Carbon and nitrogen are the two main nutrients in maize (Zea mays L.) kernels, and kernel filling and metabolism determine seed formation and germination. However, the molecular mechanisms underlying the relationship between kernel filling and corresponding carbon and nitrogen metabolism remain largely unknown.

Hybrid Beamforming Design for Self-Interference Cancellation in Full-Duplex Millimeter-Wave MIMO Systems with Dynamic Subarrays.

Full-duplex (FD) millimeter-wave (mmWave) multiple-input multiple-output (MIMO) communication is a promising solution for the extremely high-throughput requirements in future cellular systems. The hybrid beamforming structure is preferable for its low hardware complexity and low power consumption with acceptable performance. In this paper, we introduce the hardware efficient dynamic subarrays to the FD mmWave MIMO systems and propose an effective hybrid beamforming design to cancel the self-interference (SI) in the considered system.

A New Approach to Modeling Ultrashort Channel Ballistic Nanowire GAA MOSFETs.

We propose a numerical compact model for describing the drain current in ballistic mode by using an expression to represent the transmission coefficients for all operating regions. This model is based on our previous study of an analytic compact model for the subthreshold region in which the DIBL and source-to-drain tunneling effects were both taken into account. This paper introduces an approach to establishing the smoothing function for expressing the critical parameters in the model's overall operating regions.

Maize PPR278 Functions in Mitochondrial RNA Splicing and Editing.

Pentatricopeptide repeat (PPR) proteins are a large protein family in higher plants and play important roles during seed development. Most reported PPR proteins function in mitochondria. However, some PPR proteins localize to more than one organelle; functional characterization of these proteins remains limited in maize ( L.

identification of common and specific signatures in coronary heart diseases.

Coronary heart disease (CHD) is on the increase in developing countries, where lifestyle choices such as smoking, bad diet, and no exercise contribute and increase the incidence of high blood pressure and high cholesterol levels to cause CHD. Through utilization of a biomarker-based approach for developing interventions, the aim of the study was to identify differentially expressed genes (DEGs) and their association and impact on various bio-targets. The microarray datasets of both healthy and CHD patients were analyzed to identify the DEGs and their interactions using Gene Ontology, PANTHER, Reactome, and STRING (for the possible associated genes with multiple targets).

Long non-coding RNA HULC exerts oncogenic activity on papillary thyroid cancer and .

Thyroid cancer is a frequently happened malignancy in human endocrine system. Papillary thyroid cancer (PTC) presents 70-80% of all thyroid cancer cases. Herein, we probed the possible oncogenic function of long non-coding RNA (lncRNA) highly up-regulated in liver cancer (HULC) in PTC.

The Ca Sensor SCaBP3/CBL7 Modulates Plasma Membrane H-ATPase Activity and Promotes Alkali Tolerance in Arabidopsis.

Saline-alkali soil is a major environmental constraint impairing plant growth and crop productivity. In this study, we identified a Ca sensor/kinase/plasma membrane (PM) H-ATPase module as a central component conferring alkali tolerance in Arabidopsis (). We report that the SCaBP3 (SOS3-LIKE CALCIUM BINDING PROTEIN3)/CBL7 (CALCINEURIN B-LIKE7) loss-of-function plants exhibit enhanced stress tolerance associated with increased PM H-ATPase activity and provide fundamental mechanistic insights into the regulation of PM H-ATPase activity.

Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance.

Calcium is a universal secondary messenger that triggers many cellular responses. However, it is unclear how a calcium signal is coordinately decoded by different calcium sensors, which in turn regulate downstream targets to fulfill a specific physiological function. Here we show that SOS2-LIKE PROTEIN KINASE5 (PKS5) can negatively regulate the Salt-Overly-Sensitive signaling pathway in Arabidopsis.

Regulation of plasma membrane H-ATPase activity by the members of the V-SNARE VAMP7C family in arabidopsis thaliana.

The plasma membrane (PM) H-ATPase plays an important role in response to environmental stress, such as salt-alkaline stress. We have reported that the N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein Vesicle-associated membrane protein 711 (VAMP711) is involved in drought stress by regulating PM H-ATPase activity directly. In this study, we report that VAMP7C (VAMP711-14) represses PM H-ATPase activity in response to high-pH stress.

VAMP711 Is Required for Abscisic Acid-Mediated Inhibition of Plasma Membrane H-ATPase Activity.

Drought stress is a limiting environmental factor that affects plant growth and development. The plant hormone abscisic acid (ABA) plays an important role in plant drought responses. Previous studies have indicated that ABA inhibits plasma membrane H-ATPase (PM H-ATPase) activity, and the decrease in PM H-ATPase activity promotes stomatal closure under drought stress, thereby reducing water loss.

Tumor suppressive roles of eugenol in human lung cancer cells.

Background: Eugenol, a natural compound available in Syzigium aromaticum (cloves), is exploited for various medicinal applications. Eugenol induces apoptosis and functions as an anti-cancer drug in several types of tumors. We investigated the tumor suppressive role and potential mechanisms of eugenol in human lung cancer cells.

Pregabalin can decrease acute pain and morphine consumption in laparoscopic cholecystectomy patients: A meta-analysis of randomized controlled trials.

Background: Pregabalin has been used as an adjunct for the management of acute pain in laparoscopic cholecystectomy. This meta-analysis aimed to illustrate the efficacy and safety of pregabalin for pain management following laparoscopic cholecystectomy.

Methods: In March 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, and Google databases.

O-6-methylguanine-DNA methyltransferase gene promoter methylation and lung cancer risk: A meta-analysis.

Objective: To evaluate O-6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation pattern in tumor tissue and autologous controls (plasma, normal lung tissue, and bronchial lavage fluid [BLF]) in patients with nonsmall cell lung cancer (NSCLC).

Materials And Methods: We electronic searched the MEDLINE and CNKI databases to find the open published studies related to MGMT gene promoter hypermethylation in NSCLC patients. The odds ratio (OR) for hypermethylation in plasma, BLF, and tissue was pooled by fixed or random effect model according to the statistical heterogeneity across the included studies.

[In-Situ Analysis of Solid Steel Samples with Remote Double-Pulse Laser-Induced Breakdown Spectroscopy System].

In order to realize real-time, online monitoring of the component of steel and other metal smelting process, we designed a remote double-pulse laser-induced breakdown spectroscopy (LIBS) analysis system which can realize non-contact remote measurement and component analysis for long distance sample. The paper first tests the system on solid standard steel samples, which provides basis for online monitoring the component of molten steel. The experimental results show：laser focal spot is about 1mm in long distance; double-pulse ablation depth is deeper than single pulse’s; the optimum delay of double-pulse is non-consistent in different distances; the enhancement effect of double- pulse in 3.

[Quantitative analysis of alloy steel based on laser induced breakdown spectroscopy with partial least squares method].

In the present paper both the partial least squares (PLS) method and the calibration curve (CC) method are used to quantitatively analyze the laser induced breakdown spectroscopy data obtained from the standard alloy steel samples. Both the major and trace elements were quantitatively analyzed. By comparing the results of two different calibration methods some useful results were obtained: for major elements, the PLS method is better than the CC method in quantitative analysis; more importantly, for the trace elements, the CC method can not give the quantitative results due to the extremely weak characteristic spectral lines, but the PLS method still has a good ability of quantitative analysis.