Publications by authors named "Zhijia Hou"
Causal association between non-thyroidal autoimmune diseases and Graves' ophthalmopathy: A mendelian randomization study.
Adv Ophthalmol Pract Res
November 2024
Purpose: This Mendelian randomization (MR) analysis study aimed to investigate the genetic causal relationship between non-thyroidal autoimmune diseases (ADs) and Graves' ophthalmopathy (GO).
Materials: Single nucleotide polymorphisms (SNPs) associated with inflammatory bowel disease (IBD), multiple sclerosis (MS), psoriasis vulgaris (PV), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) were obtained from the IEU Open genome-wide association studies (GWAS) database, GWAS data for GO were obtained from the FinnGen database. Bidirectional MR analysis was conducted using inverse variance weighted (IVW) method, weighted median (WM) method and MR-Egger test.
CT-Based Machine Learning Radiomics Analysis to Diagnose Dysthyroid Optic Neuropathy.
Semin Ophthalmol
February 2025
Purpose: To develop CT-based machine learning radiomics models used for the diagnosis of dysthyroid optic neuropathy (DON).
Materials And Methods: This is a retrospective study included 57 patients (114 orbits) diagnosed with thyroid-associated ophthalmopathy (TAO) at the Beijing Tongren Hospital between December 2019 and June 2023. CT scans, medical history, examination results, and clinical data of the participants were collected.
OCT Radiomic Features Used for the Assessment of Activity of Thyroid Eye Disease.
J Craniofac Surg
September 2024
Article Synopsis
- This study focused on creating deep-learning radiomics models using optical coherence tomography (OCT) scans to assess thyroid eye disease activity in 33 patients with 66 affected eyes.
- Patients were classified into active and inactive groups based on their clinical activity scores, and OCT scans were analyzed to extract relevant features using advanced statistical methods.
- The study found that the support vector machine (SVM) model had better performance for choroid features (AUC of 0.813) compared to retinal features in predicting disease activity, suggesting OCT-based analysis could improve clinical evaluations.
Severity Identification of Graves Orbitopathy via Random Forest Algorithm.
Horm Metab Res
October 2024
This study aims to establish a random forest model for detecting the severity of Graves Orbitopathy (GO) and identify significant classification factors. This is a hospital-based study of 199 patients with GO that were collected between December 2019 and February 2022. Clinical information was collected from medical records.
View Article and Find Full Text PDFStepwise self-inflating hydrogel expansion for congenital anophthalmia and blind microphthalmia: Over 15 years' experience in China.
J Plast Reconstr Aesthet Surg
March 2024
Article Synopsis
- Self-inflating hydrogel expanders are effective in treating congenital anophthalmia and blind microphthalmia, resulting in significant increases in palpebral fissure height and length.
- A review of 161 patient records revealed a few complications, including expander migration, but these were rare and manageable with further surgical interventions.
- Patients with a relative axial length of less than 0.5 are more likely to require additional expansion procedures after initial treatment.
Three-dimensional soft tissue reconstruction and volume measurement used for the diagnosis of dysthyroid optic neuropathy.
Graefes Arch Clin Exp Ophthalmol
June 2024
Purpose: Dysthyroid optic neuropathy (DON) leads to vision loss. This study aimed to investigate a new method that can directly evaluate the change in muscle cone inner volume (MCIV) and distinguish DON orbits from non-DONs.
Materials And Methods: This study included 54 patients (108 orbits) who were diagnosed with thyroid eye disease and treated at the Beijing Tongren Hospital between December 2019 and September 2021.
Aim: To evaluate volume differences between anterior and posterior orbit and demographic characteristics of Chinese patients with congenital microphthalmia.
Methods: A retrospective cohort study, involving 169 unilateral congenital microphthalmia patients aged between 1 and 57 years old was conducted. Three-dimensional images of the orbit were generated from past CT scans, and digital orbital volume comprehensive measurement was done.
Article Synopsis
- The study focused on treating severe cicatricial entropion and trichiasis in upper eyelids, analyzing long-term outcomes of combined surgical approaches.
- Data was collected from 39 patients treated at Beijing Tongren Eye Center between 2019 and 2021, with a follow-up period averaging over 20 months.
- Results showed a high success rate (around 94.74% shortly after surgery) for various surgical techniques, indicating effective long-term stability for these complex cases.
Graves' ophthalmopathy (GO), the most frequent extrathyroidal manifestation of Graves' disease (GD), can lead to a significant decline in the quality of life in patients. Exosomes, which contain proteins, lipids and DNA, play important roles in the pathological processes of various diseases. However, their roles in Graves' ophthalmopathy are still unclear.
View Article and Find Full Text PDFUsing the Random Forest Algorithm to Detect the Activity of Graves Orbitopathy.
J Craniofac Surg
March 2023
Article Synopsis
- The study aims to create a random forest model for detecting active and quiescent phases in patients with Graves Orbitopathy (GO).
- It included 243 patients and used various clinical characteristics as predictors, comparing the model's effectiveness against logistic regression and other machine learning methods.
- The random forest model demonstrated better accuracy and reliability in detecting GO activity, achieving high sensitivity and specificity compared to other models.
This study aimed to describe the correlation between some clinical features and orbital soft tissue volume in Graves orbitopathy (GO). The authors collected computed tomography scans from 56 untreated GO patients and measured fat volume (FV), intraorbital and extraorbital FV (IFV, EFV), bony cavity volume (BV), and extraocular muscle volume (MV) of the 112 orbits by using Mimics software. The ratio of soft tissue volume and BV were used to eliminate the individual variations.
View Article and Find Full Text PDFBidirectional tightening of the anterior lamella for involutional lower eyelid entropion.
Can J Ophthalmol
August 2023
Objective: Involutional entropion of the lower eyelid is commonly encountered in the elderly population. An ideal surgical method is supposed to address the underlying horizontal and vertical lower lid laxity simultaneously. This study aims to assess the effectiveness of bidirectional tightening of the anterior lamella to correct involutional lower lid entropion.
View Article and Find Full Text PDFBackground: Studies on the factors related to lacrimal gland prolapse (LGP) in patients with thyroid-associated ophthalmopathy (TAO) are limited. This study aimed to assess the factors associated with LGP on magnetic resonance imaging (MRI) and its relation to TAO activity .
Methods: Thirty-six patients (72 orbits) with inactive TAO (43 orbits, Clinical Activity Score [CAS] < 3) or active TAO (29 orbits, CAS ≥3) were investigated retrospectively.
Objective: To analyze the stimulating effect of axial length development on orbital volume development in patients (ages 12-60 years) with congenital microphthalmia.
Methods: This retrospective cohort study included 43 patients (86 eyes) with congenital microphthalmia. Three-dimensional images of the orbit were generated from past computed tomography scans, and digital orbital volume and axial length measurements were taken.
Article Synopsis
- Children with congenital glaucoma often develop acquired epiblepharon in the lower eyelid, leading to entropion and corneal damage.
- A study of 15 patients found that those with lower eyelid entropion had significantly longer ocular axes and larger corneal diameters compared to those without.
- The findings suggest that rapid growth in these ocular measurements may be a key factor in the development of lower eyelid entropion in kids with congenital glaucoma, indicating a need for careful monitoring in such cases.
Background: Etiologies of congenital microphthalmia and anophthalmia are unclear and commonly thought to be homogenous. To test if risk factors are similar for these two diseases, we compared the risk factors between congenital microphthalmia and anophthalmia in a large Chinese cohort.
Methods: A total of 347 patients with congenital microphthalmia or anophthalmia diagnosed by magnetic resonance imaging (MRI), computed tomography (CT) or ultrasound from 2011 to 2018 were enrolled.
Article Synopsis
- The study aimed to evaluate an individualized treatment strategy for children with congenital microphthalmos and anophthalmos, focusing on their specific conditions and ages.
- It involved 24 patients treated at Beijing Tongren Hospital from 2009 to 2017, with different approaches based on age, including cyst retention, hydrogel expanders, and eyelid surgeries.
- The results showed that most patients achieved good cosmetic outcomes and were able to use ocular prostheses, with no complications from the procedures noted.
Background: Rupture of the medial canthal ligament can be caused by many events. It remains a challenge to rebuild the drainage system and restore the function. The aim of this study was to evaluate the clinical efficacy of medial canthoplasty combined with conjunctivodacryocystorhinostomy (CDCR) in patients with medial telecanthal deformities and lacrimal drainage system damage.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate the characteristics of orbital cysts in patients with microphthalmos and how these cysts relate to orbital volume in a sample of 120 Chinese patients.
- Using computed tomography (CT) scans, researchers analyzed the location, size, and volume of the cysts, finding that anterior cysts were larger and had different positions compared to posterior ones.
- Results indicated that patients with larger cysts had a closer resemblance in orbital measurements to their unaffected eye, suggesting that larger cysts could potentially help in achieving a more balanced appearance in microphthalmic cases.
Article Synopsis
- - This study assessed the growth of bony orbits in children with congenital unilateral blind microphthalmia after they underwent treatment with hydrogel expanders to evaluate developmental changes.
- - Thirteen pediatric patients were included, with measurements taken before and after the treatment using CT scans, focusing on orbital volume, dimensions, and rim development.
- - Results showed significant increases in orbital volume and width three years post-treatment, indicating that hydrogel expanders effectively aid in correcting orbital asymmetry associated with microphthalmia.
Article Synopsis
- The study aimed to assess the surgical outcomes of reconstructing full-thickness defects in the lower eyelid caused by tumor excision from 2008 to 2013.
- The most common malignant tumors found were basal cell carcinoma, sebaceous gland carcinoma, and malignant melanoma, with no tumor recurrence reported during follow-up.
- The Hughes technique used for reconstruction resulted in satisfactory cosmetic and functional outcomes, with some minor complications addressed through revision surgery.
Article Synopsis
- * Clinical features, surgical techniques, and pathology results were documented to provide insights into the treatment process.
- * The study concludes that using a simplified approach to partially excise the tumor and apply skin grafting can enhance cosmetic results for patients.
Cosmetic shell fitting over a sensitive cornea in mild phthisis bulbi using total conjunctival flap.
Aesthetic Plast Surg
April 2013
Background: Cosmetic scleral shells provide a superior alternative to enucleation or evisceration in the setting of phthisis bulbi. However, corneal irritation often minimizes the wearing time of a scleral shell. This study aimed to evaluate the clinical effectiveness of a total conjunctival flap covering in the management of mild phthisis bulbi with a sensitive cornea.
View Article and Find Full Text PDF[Clinical features of blepharochalasis and surgical treatment of associated deformities].
Zhonghua Yan Ke Za Zhi
August 2012
Article Synopsis
- The study focuses on blepharochalasis, a condition affecting the eyelids, analyzing clinical features and outcomes of surgical interventions in 54 patients over a span of 6 to 60 months.
- The average onset age is around 9.3 years, with a duration of 2 to 16 years, and surgeries like blepharoplasty and ptosis repair led to improved eyelid appearance and patient satisfaction.
- Post-surgery, most patients reported no complications such as dry eyes, with only minor issues requiring further procedures, indicating that surgical treatment is generally safe and effective for cosmetic correction.*
Purpose: To report the results of enlarging orbital volume in consecutive cases of severe congenital microphthalmia by means of solid hydrophilic tissue expanders.
Methods: The medical records of consecutive patients with congenital microphthalmia who underwent the placement of a hydrogel expander were retrospectively reviewed. Main outcome measures were orbital tissue expansion, prosthetic retention, and patient family satisfaction.