Polylactide (PLA) is inherently brittle and lacks ductility, which greatly restricts its range of applications. In order to address these issues, we blended PLA with biodegradable poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)), and introduced epoxidized soybean oil (ESBO) as a reactive modifier to enhance the properties of the PLA/P(3HB-co-4HB) blends. Furthermore, we used theoretical calculations, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Soxhlet extraction, differential scanning calorimetry (DSC), polarising optical microscopy (POM), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and mechanical testing to investigate the compatibility, crystallization behavior, microstructure, thermal and mechanical properties of the PLA/P(3HB-co-4HB)/ESBO blends.
View Article and Find Full Text PDFNLRP12 plays a significant role in cellular functional behavior and immune homeostasis, influencing inflammation, tumorigenesis, and prognosis. This study aimed to explore its specific effects on the tumor microenvironment (TME) and its contribution to heterogeneity in ovarian cancer (OV) through bioinformatics analysis and experimental verification. Utilizing various bioinformatics databases and clinical specimens, we investigated NLRP12 expression and its relationship with OV prognosis and immune infiltration.
View Article and Find Full Text PDFRadical-based advanced oxidation processes (AOPs) are among the most effective technologies employed to destroy organic pollutants. Compared to common inorganic radicals, such as OH, O, and SO, organic radicals are widespread, and more selective, but are easily overlooked. Furthermore, a systematic understanding of the generation and contributions of organic radicals remains lacking.
View Article and Find Full Text PDFBiochem Biophys Res Commun
November 2024
The liver is vitally metabolic for a multitude of biochemical reactions. Consequently, it generates many free radicals and reactive oxygen species, rendering it more susceptible to oxidative stress-induced damage. Oxidative stress represents a pivotal factor in the pathogenesis of liver diseases.
View Article and Find Full Text PDFThe progression of hepatocellular carcinoma (HCC) is influenced by disrupted metabolic processes, presenting challenges in prognostic outcomes. Hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality, is closely associated with metabolic reprogramming and stem cell-like properties in liver cancer stem cells (LCSCs). This study explored the potential molecular mechanisms by which tLyP-1-modified extracellular vesicles (EVs) delivering CTCF shRNA (tLyp-1-EV-shCTCF) regulate mitochondrial DNA methylation-induced glycolytic metabolic reprogramming and LCSC self-renewal.
View Article and Find Full Text PDFThis study reports a pH/magnetic dual-responsive hemicellulose-based nanocomposite hydrogel with nearly 100 % carbohydrate polymer-based and biodegradable polymer compositions for drug delivery. We synthesized pure FeO magnetic nanoparticles (FeO MNPs) using a co-precipitation method, then engineering xylan hemicellulose (XH), acrylic acid, poly(ethylene glycol) diacrylate, and FeO to synthesize the pH/magnetic dual-responsive hydrogel (FeO@XH-Gel), through graft polymerization on XH with in-situ doping FeO MNPs initiated by the ammonium persulfate/tetramethylethylenediamine redox system. Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (H NMR), X-ray diffractometry (XRD), scanning electron microscopy and energy dispersive spectrometer (SEM-EDS), high-resolution transmission electron microscopy (HRTEM), Brunauer-Emmett-Teller (BET), swelling gravimetric analysis, vibrating sample magnetometer (VSM) were employed to analyze the hydrogel's chemical structures, morphologies, pH-responsive behaviors, and magnetic responsiveness characteristics, mechanical and rheological properties, as well as cytotoxicity and biodegradability.
View Article and Find Full Text PDFThe inherent toxicity and persistence of emerging contaminants such as antibiotics and endocrine disruptors pose substantial threats to the environment. Advanced oxidation processes (AOPs) employed for oxidative degradation could yield toxic oxidation by-products (OBPs), including organic acids and aromatic hydrocarbons. Despite their typically low concentrations, OBPs require scrutiny owing to their potential health risks.
View Article and Find Full Text PDFPolymerized β-actin may provide a structural basis for chromatin accessibility and actin transport into the nucleus can guide mesenchymal stem cell (MSC) differentiation. Using MSC, we show that using CK666 to inhibit Arp2/3 directed secondary actin branching results in decreased nuclear actin structure, and significantly alters chromatin access measured with ATACseq at 24 h. The ATAC-seq results due to CK666 are distinct from those caused by cytochalasin D (CytoD), which enhances nuclear actin structure.
View Article and Find Full Text PDFElevated substance P can be utilized to predict early mortality during the first week of cerebral infarction. Whether aprepitant, a substance P receptor blocker could be utilized to alleviate poststroke pneumonia which is investigated in this study. Intraluminal monofilament model of middle cerebral artery occlusion (MCAO) was constructed in C57BL/6J male mice, and the relative expression of substance P was detected in collected bronchoalveolar lavage fluid (BALF) and lung tissue homogenate at 24 hours, 48 hours, and 72 hours poststroke.
View Article and Find Full Text PDFIn this study, graphene oxide (GO) was modified via electrostatic interactions and chemical grafting by silica (SiO), and two SiO@GO hybrids (GO-A and GO-B, respectively) with different structures were obtained and carefully characterized. Results confirmed the successful grafting of SiO onto the GO surface using both strategies. The distribution of SiO particles on the surface of GO-A was denser and more agglomerated, while it was more uniform on the surface of GO-B.
View Article and Find Full Text PDFThis study used a simple mechanical ball milling strategy to significantly improve the ability of MnO to activate peracetic acid (PAA) for sustainable and efficient degradation of organic micropollutant (like bisphenol A, BPA). BPA was successfully removed and detoxified via PAA activation by the bm-MnO within 30 min under neutral environment, with the BPA degradation kinetic rate improved by 3.4 times.
View Article and Find Full Text PDFImproving the limited energy storage capacity of dielectric materials has long been an attractive challenge. In this work, a four-phase hybridized nanocomposite was designed. The linear polymer polyimide (PI) was added to the ferroelectric polymer polyvinylidene fluoride (PVDF) and compounded with a nanoceramic BT@SiO with a core-shell structure.
View Article and Find Full Text PDFClarkson disease, or monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome (ISCLS), is a rare, relapsing-remitting disorder featuring the abrupt extravasation of fluids and proteins into peripheral tissues, which in turn leads to hypotensive shock, severe hemoconcentration, and hypoalbuminemia. The specific leakage factor(s) and pathways in ISCLS are unknown, and there is no effective treatment for acute flares. Here, we characterize an autonomous vascular endothelial defect in ISCLS that was recapitulated in patient-derived endothelial cells (ECs) in culture and in a mouse model of disease.
View Article and Find Full Text PDFBackground: Foreign bodies (FBs) are a common emergency in medical institutions, that can occur in any area and among people of any age, which are common public health problems. Understanding the epidemiological characteristics of FBs is crucial for their prevention and control. The purpose of this study was to analyze the epidemiological characteristics of FBs worldwide through the data from the Global Burden of Disease Study 2019 (GBD 2019).
View Article and Find Full Text PDFMicromachines (Basel)
December 2023
Embedded liquid cooling is a preferred solution for dissipating the heat generated by high-power chips. The cooling capacity and pump power consumption of embedded liquid cooling heat sinks differ significantly between different structures. To achieve an accurate match between cooling capacity and heat dissipation requirements, the selection of a liquid-cooled heat sink should be carefully considered in conjunction with the heat dissipation needs of heat sources in real-world thermal management issues.
View Article and Find Full Text PDFIntroduction: Longitudinal effect of diet-induced obesity on bone is uncertain. Prior work showed both no effect and a decrement in bone density or quality when obesity begins prior to skeletal maturity. We aimed to quantify long-term effects of obesity on bone and bone marrow adipose tissue (BMAT) in adulthood.
View Article and Find Full Text PDFIn this work, a total of 18 types of choline chloride, betaine, and L-proline-based deep eutectic solvents (DESs) were synthesized to determine the extraction yield of a natural polysaccharide (PSA) from Dysosma versipellis using an ultrasound-assisted extraction method. Results indicate that the choline-oxalic acid-based DES has the best extraction yield for PSA due to the proper physical-chemical properties between PSA and DES. To evaluate the optimal extraction conditions, a response surface methodology was carried out.
View Article and Find Full Text PDFIn this work, we synthesized polydopamine nanoparticles (PDNPs-M, M = I, II, III, and IV) with uniform particle sizes but varying l-arginine (Arg) contents (0%, 0.53%, 3.73%, and 6.
View Article and Find Full Text PDFSide reactions caused by highly active water molecules, including severe corrosion, hydrogen evolution, and dendrite growth, are impediments to the advancement of aqueous zinc ion batteries (ZIBs). Here, inspired by the pivotal role of plant fibers to prevent dehydration in nature, we designed a unique water-retaining plant fiber (WRPF) separator with strong hygroscopic ability to adsorb and trap water molecules. Elaborated theoretical and experimental characterizations prove that high-activity water could be sequestered by a WRPF separator, alleviating water-induced side reactions and accelerating the desolvation of hydrate Zn.
View Article and Find Full Text PDFPeracetic acid (PAA) is regarded as an environmentally friendly oxidant because of its low formation of toxic byproducts. However, this study revealed the potential risk of generating disinfection byproducts (DBPs) when treating iodine-containing wastewater with PAA. The transformation efficiency of bisphenol A (BPA), a commonly detected phenolic contaminant and a surrogate for phenolic moieties in dissolved organic matter, by PAA increased rapidly in the presence of I, which was primarily attributed to the formation of active iodine (HOI/I) in the system.
View Article and Find Full Text PDFIn this work, Glucomannan was modified with dopamine to synthesize a new polysaccharide Schiff base (GAD). After confirmation of GAD by NMR and FT-IR spectroscopic methods, it was introduced as a sustainable corrosion inhibitor with excellent anti-corrosion action for mild steel in 0.5 M hydrochloric acid (HCl) solution.
View Article and Find Full Text PDFAs a novel strategy, peracetic acid (PAA) based advanced oxidation processes (AOPs) are being used in micropollutant elimination due to their high oxidation and low toxicity. In this study, CoCaAl-LDO as a kind of layered double oxides (LDOs) was successfully synthesized, and it is the first time to apply CoCaAl-LDO for activating PAA. The CoCaAl-LDO/PAA system showed excellent removal efficiencies for various micropollutants with removal ratios ranging from 90.
View Article and Find Full Text PDFBackgrounds: The widespread coronavirus disease 2019 (COVID-19) outbreak impacted the mental health of infected patients admitted to Fangcang shelter hospital a large-scale, temporary structure converted from existing public venues to isolate patients with mild or moderate symptoms of COVID-19 infection.
Objective: This study aimed to investigate the risk factors of the infected patients from a new pharmacological perspective based on psychiatric drug consumption rather than questionnaires for the first time.
Methods: We summarised the medical information and analysed the prevalence proportion, characteristics, and the related risk factors of omicron variants infected patients in the Fangcang Shelter Hospital of the National Exhibition and Convention Center (Shanghai) from 9 April 2022 to 31 May 2022.