Russian Doll-like 3d-4f Cluster Wheels with Slow Relaxation of Magnetization.

The solvothermal reactions of LnCl·6HO and MCl·6HO (M = Co, Ni) with 2,2'-diphenol (HL) and 5,7-dichloro-8-hydroxyquinoline (HL) gave three 3d-4f heterometallic wheel-like nano-clusters [LnM(L)(L)(-OH)(OCH)Cl(CHCN)]Cl·HO (Ln = Dy, M = Co, = 3 for ; Ln = Dy, M = Ni, = 0 for ; Ln = Tb, M = Ni, = 0 for ) with similar cluster structure. The innermost Ln(III) ion is encapsulated in a planar Ln ring which is further embedded in a chair-conformation M ring, constructing a Russian doll-like 3d-4f cluster wheel Ln(III)⸦Ln⸦M. and show obvious slow magnetic relaxation behavior with negligible opening of the magnetic hysteresis loop.

Treatment of obstructive sleep apnea with a simple CPAP device.

Purpose: CPAP is the "gold standard" treatment for obstructive sleep apnea (OSA). Current CPAP models have developed additional functions including automatic CPAP and pressure relief. However, CPAP adherence has not improved over the last three decades.

Anticancer activity of four trinuclear cobalt complexes bearing bis(salicylidene)-1,3-propanediamine derivatives.

Schiff base and its complexes are being paid more and more interests for their great prospects in biological applications. We reported here four cobalt(II) complexes [Co(L)(HCOO)] (1), [Co(L)(HCOO)(CHOH)]·2CHOH (2), [Co(HL)(OAc)(DMF)] (3) and [Co(HL)(HCOO)(DMF)]·2HO (4) bearing the bis-Schiff base ligand of bis(5-bromosalicylidene)-1,3-propanediamine (HL), bis(5-bromosalicylidene)-2-methyl-1,3-propanediamine (HL), bis(5-chlorosalicylidene)-2-hydroxyl-1,3-propanediamine (HL) and bis(5-bromosalicylidene)-2-hydroxyl-1,3-propanediamine (HL), respectively. The anti-tumor activities of the four titled complexes were screened on a series of tumor cell lines.

Novel method for evaluating the upper airway resistance using the ratio of neural respiratory drive to flow in OSA.

Study Objectives: Sleep is associated with a reduction in ventilation and an increase in upper airway resistance (UAR) in patients with obstructive sleep apnea (OSA). However, there is no consensus on the standard for assessment of UAR and therefore it is important to develop a method to reliably assess UAR in patients with OSA. The purpose of the present study is to determine whether the ratio of neural respiratory drive (NRD) to flow can be used to assess changes in UAR in OSA during sleep.

Effect of Dexmedetomidine on duration of mechanical ventilation in septic patients: a systematic review and meta-analysis.

Background: Because of its analgesic and light sedative properties, the highly selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) has been suggested for the treatment of septic patients, but its effect on the duration of mechanical ventilation remains unclear. The present study was conducted to review the extant literature in DEX and determine its influence on ventilation time in adult septic patients.

Methods: Databases of PubMed, Cochrane, and EMBASE were applied till 20th January 2019 without language restriction.

Absence of dynamic hyperinflation during exhaustive exercise in severe COPD reflects submaximal IC maneuvers rather than a nonhyperinflator phenotype.

Approximately 20% of chronic obstructive pulmonary disease (COPD) patients have been considered to have a "nonhyperinflator phenotype." However, this judgment depends on patients making a fully maximal inspiratory capacity (IC) maneuver at rest, since the IC during exercise is compared with this baseline measurement. We hypothesized that IC maneuvers at rest are sometimes submaximal and tested this hypothesis by measuring IC and associated neural respiratory drive at rest and during inhalation of CO and exercise in patients with COPD.

Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD: A Randomized Controlled Trial.

Background: In COPD, functional status is improved by pulmonary rehabilitation (PR) but requires specific facilities. Tai Chi, which combines psychological treatment and physical exercise and requires no special equipment, is widely practiced in China and is becoming increasingly popular in the rest of the world. We hypothesized that Tai Chi is equivalent (ie, difference less than ±4 St.

Physiological responses to Tai Chi in stable patients with COPD.

We compared the physiological work, judged by oxygen uptake, esophageal pressure swing and diaphragm electromyography, elicited by Tai Chi compared with that elicited by constant rate treadmill walking at 60% of maximal load in eleven patients with COPD (Mean FEV1 61% predicted, FEV1/FVC 47%). Dynamic hyperinflation was assessed by inspiratory capacity and twitch quadriceps tension (TwQ) elicited by supramaximal magnetic stimulation of the femoral nerve was also measured before and after both exercises. The EMGdi and esophageal pressure at the end of exercise were similar for both treadmill exercise and Tai Chi (0.

Association Between the CYP1B1 Polymorphisms and Lung Cancer Risk: A Meta-Analysis.

The previously published data on the association between the cytochrome P450 1B1 Leu432Val, Asn453Ser, and Ala119Ser polymorphisms and lung cancer risk have remained controversial. Hence, we performed a meta-analysis to investigate the association between cytochrome P450 1B1 Leu432Val, Asn453Ser, and Ala119Ser polymorphisms and lung cancer risk under different inheritance models. A total of 22 studies were identified, including 2881 cases and 3653 controls for Leu432Val polymorphism (from 13 studies), 3009 cases and 3887 controls for Asn453Ser polymorphism (from 5 studies), and 1301 cases and 2045 controls for Ala119Ser polymorphism (from 4 studies).

[Anti-miR-145 promotes human airway smooth muscle cell proliferation and osteopontin synthesis in vitro].

Objective: To investigate the effect of anti-miR-145 on human airway smooth muscle cell (HASMC) proliferation and osteopontin systhesis in vitro and explore the mechanisms.

Methods: HASMCs were treated with 10-100 nmol/L anti-miR-145, and the cell proliferation and apoptosis were investigated using a CCK-8 assay and flow cytometry, respectively. The changes in osteopontin synthesis after the treatment was quantified with Western blotting.

[Assessment of neural respiratory drive in humans].

Objective: Assessment of neural respiratory drive is useful for diagnosis of dyspnea and respiratory failure with unknown causes. The purpose of the study was to compare the sensitivity of trandiaphragmatic pressure (Pdi) and diaphragm electromyogram (EMGdi) in assessment of neural respiratory drive.

Methods: A combined catheter with 10 electrodes and 2 balloons was used to record EMGdi and Pdi during CO2 rebreathing.

[Prevalence of central sleep apnea in different age groups of children with sleep apnea-hypopnea].

Objective: To explore the prevalence of central sleep apnea in different age groups of children with sleep apnea-hypopnea (SAH).

Methods: A total of 431 children with SAH diagnosed by overnight polysomnography at our Sleep Center were retrospectively studied. They were divided into 3 groups based on their ages: toddler group (1 - < 3 years old), preschool group (3 - < 6 years old) and school group (6 - < 13 years old).

Comparison of manual versus automatic continuous positive airway pressure titration and the development of a predictive equation for therapeutic continuous positive airway pressure in Chinese patients with obstructive sleep apnoea.

Background And Objective: Whether the therapeutic nasal continuous positive airway pressure (CPAP) derived from manual titration is the same as derived from automatic titration is controversial. The purpose of this study was to compare the therapeutic pressure derived from manual titration with automatic titration.

Methods: Fifty-one patients with obstructive sleep apnoea (OSA) (mean apnoea/hypopnoea index (AHI) = 50.

Effect of expiratory load on neural inspiratory drive.

Background: Neural respiratory drive is usually measured during inspiration, even in patients with chronic obstructive pulmonary disease (COPD) in whom the primary physiological deficit is expiratory flow limitation. The purpose of the study was to test the hypothesis that inspiratory muscle neural respiratory drive could be used to assess expiratory load.

Methods: Ten healthy young men, (26 ± 4) years old, were asked to expire through a tube immersed in water where an expiratory load was required.

[Neural respiratory drive in patients with obstructive sleep apnea].

Objective: To evaluate the variability of neural respiratory drive in patients with obstructive sleep apnea (OSA) and the effect of continuous positive airway pressure (CPAP) upon neural respiratory drive.

Methods: We recorded diaphragm electromyogram (EMGdi) with multi-pair esophageal electrodes and its variability during wakefulness, sleep and treatment with CPAP in 13 patients with moderate to severe OSA diagnosed by an overnight full polysomnography (OSA group). Six normal subjects (control group) were also studied.

Systematical approach of formulation and process development using roller compaction.

The roller compaction process has gained heightened interest in the pharmaceutical industry. In this review, common excipients and equipment used for dry granulation are described. Roller compaction process parameters and their impact on the critical quality attributes of the final product, as well as evaluation methods for roller compaction product such as ribbons and granules, are discussed.

Selections of the cylinder implant neck taper and implant end fillet for optimal biomechanical properties: a three-dimensional finite element analysis.

In this paper, effects of the implant neck taper and the implant-end fillet on the maximum Von Mises stresses were evaluated in jaw bones, and maximum displacements examined in an implant-abutment complex by a finite element method (FEM). The implant-neck tapers (T) ranged from 45 degrees to 70 degrees , and fillets of implant ends (R) ranged from 0.5 to 1.

catena-Poly[[aqua-[3-(3-pyrid-yl)acrylato]gadolinium(III)]-bis-[μ-3-(3-pyrid-yl)acrylato]].

In the title compound, [Gd(C(8)H(6)NO(2))(3)(H(2)O)](n), the gadolinium(III) ion is coordinated by eight carboxyl-ate O atoms and one water mol-ecule. The carboxyl-ate ligands bridge pairs of gadolinium(III) ions, forming a zigzag chain along [100]. Hydrogen bonds link the chains into sheets parallel to (001).

Poly[[μ(3)-3-(3-pyrid-yl)acrylato-κN:O:O'][μ(2)-3-(3-pyrid-yl)acrylato-κO,O':O][μ(2)-3-(3-pyrid-yl)acrylato-κO:O')]gadolinium(III)].

In the title compound, [Gd(C(8)H(6)NO(2))(3)](n), the Gd(III) ion is in a bicapped trigonal prismatic coordination environment formed by seven O atoms and one N atom, derived from seven different 3-(3-pyrid-yl)acrylate (3-PYA) ligands. Gd(III) ions are bridged by bidentate and tridentate 3-PYA ligands, resulting in a two-dimensional structure.

catena-Poly[[diaqua-manganese(II)]-di-μ-pyridine-3-sulfonato-κN:O;κO:N].

In the title polymeric complex, [Mn(C(5)H(4)NO(3)S)(2)(H(2)O)(2)](n), the Mn atom is located on a centre of inversion and is coordinated by two O atoms and two N atoms derived from four different pyridine-3-sulfonate (pySO(3)) ligands, and two O atoms derived from two water mol-ecules in a distorted trans-N(2)O(4) octa-hedral geometry. The metal atoms are bridged by the pySO(3) ligands to form a one-dimensional chain. The chains are further connected into a three-dimensional architecture via hydrogen bonds.

catena-Poly[[diaquacadmium(II)]bis-(μ-pyridine-3-sulfonato)-κN:O;κO:N].

In the title polymeric complex, [Cd(C(5)H(4)NO(3)S)(2)(H(2)O)(2)](n), the Cd atom is located on a centre of inversion and is coordinated by two O atoms and two N atoms, derived from four different pyridine-3-sulfonate ligands, and two O atoms derived from two water mol-ecules, forming a distorted trans-N(2)O(4) octa-hedral geometry. The topology of the polymer is a one-dimensional chain mediated by bridging pyridine-3-sulfonate anions. These are connected into a three-dimensional architecture via hydrogen bonds.

Effect of milling and compression on the solid-state Maillard reaction.

The effects of milling and compression on the solid-state Maillard reaction between metoclopramide hydrochloride and lactose were investigated. Anhydrous metoclopramide hydrochloride was milled for various times, and then mixed with amorphous lactose. The mixtures were stored at 105 degrees C and 0% RH.

Kinetic study of the Maillard reaction between metoclopramide hydrochloride and lactose.

The purpose of this work is to study the apparent solid-state kinetics of the Maillard reaction of the colyophilized metoclopramide hydrochloride (MCP) and lactose system and to elucidate some of the effects of molecular mobility on the kinetic behavior of the amorphous mixture. Colyophilized MCP-lactose mixtures (1:9 molar ratio) were stored at temperatures ranging from 100 to 115 degrees C (above the glass transition temperature, Tg=99.7 degrees C).

Quantitative determination of polymorphic composition in intact compacts by parallel-beam X-ray powder diffractometry.

This paper details the development of a method using parallel-beam X-ray powder diffractometry as a novel means of determining polymorphic composition in intact compacts. Two polymorphic systems, chlorpropamide and glycine, were selected. The polymorphic components were weighed, mixed, and compressed using a Carver press with 3/8-in.