Publications by authors named "Zhihui Mu"
Article Synopsis
- Fibro-adipogenic progenitors (FAPs) in muscle tissues help muscle regeneration but become senescent in aging, affecting their interaction with muscle progenitor/stem cells (MPCs), especially in Hutchinson-Gilford progeria syndrome (HGPS).
- In a study comparing normal WT mice to Zmpste24 (Z24) mice, Z24 mice showed significantly more FAPs and fewer MPCs, with a high percentage of senescent FAPs, which negatively impacted the proliferation and muscle formation capabilities of MPCs.
- Administering the senolytic drug fisetin successfully reduced senescent FAPs, improved the function of MPCs, and showed promising results in