Implications of Extrathyroidal Extension Invading Only the Strap Muscles in Papillary Thyroid Carcinomas.

Based on the new TNM classification, differentiated thyroid carcinomas with extrathyroidal extension (ETE) into the strap muscles are designated as T3b. The current study analyzed the clinical significance of this new stage in patients with papillary thyroid cancer (PTC). This retrospective cohort study included 4045 eligible PTC patients.

Large-Scale Comparative Analysis Reveals A Simple Model To Predict The Prevalence Of Thyroid Nodules.

Background: The frequency of thyroid nodules (TNs) has increased rapidly in recent decades. We established a simple, effective model to predict TN occurrence by a large-scale comparative analysis of the Chinese population.

Subjects And Methods: A total of 13,307 subjects were included to screen risk factors between the case group (TN+) and the control group (TN-) by univariate and multivariate analyses.

Virucidal activity and the antiviral mechanism of acidic polysaccharides against Enterovirus 71 infection in vitro.

Enterovirus 71 (EV71) is the predominant pathogen for severe hand, foot, and mouth disease (HFMD) in children younger than 5 years, and currently no effective drugs are available for EV71. Thus, there is an urgent need to develop new drugs for the control of EV71 infection. In this study, LJ04 was extracted from Laminaria japonica using diethylaminoethyl cellulose-52 with 0.

Multiple Simultaneous Rare Distant Metastases as the Initial Presentation of Papillary Thyroid Carcinoma: A Case Report.

Papillary thyroid carcinoma (PTC) commonly metastasizes to regional lymph nodes. However, they infrequently cause rare distant metastases (RDMs), with the exclusion of lungs and bone metastases. RDMs are seldom identified prior to a primary thyroid cancer diagnosis.

The deposition of VWO on the CuCeO microflower for the selective catalytic reduction of NO with NH at low temperatures.

NO emissions are a major environmental problem, and the selective catalytic reduction (SCR) is the most effective method to convert NO in flue gas into harmless N and HO. In this work, a new carrier, CuCeO microflower assembled from a large number of copper-cerium mixed oxide nanosheets, is firstly developed to load vanadium-tungsten mixed oxides (VWO) for the SCR of NO with NH. The resultant optimal VWO/CuCeO catalyst exhibits significantly enhanced low-temperature de-NO performance with the NO conversion of 60% at 180 °C, over 90% from 240 °C to 390 °C under the gas hourly space velocity (GHSV) of 36,000 h.

Optimizing the synthesis of SnO/TiO/RGO nanocomposites with excellent visible light photocatalytic and antibacterial activities.

Multifunctional SnO/TiO/RGO nanocomposites with enhanced photocatalytic degradation and antibacterial activity have been successfully synthesized by a facile one-pot environmentally friendly green hydrothermal route using titanium tetrabutoxide (TBOT), NaSnO and graphene oxide (GO) without reducing agents and any structure-directing agents. The results demonstrate that the reaction pH conditions play important roles in the control of the crystallographic phases of TiO and SnO. In addition, the visible-light-active photocatalytic and antibacterial activities of the synthesized composites were measured for the degradation of rhodamine B (RhB) and the growth inhibition of the Gram-negative bacteria Escherichia coli (E.

Striatopallidal Pathway Distinctly Modulates Goal-Directed Valuation and Acquisition of Instrumental Behavior via Striatopallidal Output Projections.

The striatopallidal pathway is specialized for control of motor and motivational behaviors, but its causal role in striatal control of instrumental learning remains undefined (partly due to the confounding motor effects). Here, we leveraged the transient and "time-locked" optogenetic manipulations with the reward delivery to minimize motor confounding effect, to better define the striatopallidal control of instrumental behaviors. Optogenetic (Arch) silencing of the striatopallidal pathway in the dorsomedial striatum (DMS) and dorsolateral striatum (DLS) promoted goal-directed and habitual behaviors, respectively, without affecting acquisition of instrumental behaviors, indicating striatopallidal pathway suppression of instrumental behaviors under physiological condition.

Preparation of Pd/C by Atmospheric-Pressure Ethanol Cold Plasma and Its Preparation Mechanism.

Treatment with atmospheric-pressure (AP) hydrogen cold plasma is an effective method for preparing highly active supported metal catalytic materials. However, this technique typically uses H as working gas, which is explosive and difficult to transport. This study proposes the use of PdCl as a Pd precursor and activated carbon as the support to fabricate Pd/C catalytic materials (Pd/C-EP-Ar) by using ethanol-which is renewable, easily stored, and safe-combined with AP cold plasma (AP ethanol cold plasma) followed by calcination in Ar gas at 550 °C for 2 h.

The usefulness of b value threshold map in the evaluation of rectal adenocarcinoma.

Purpose: To investigate the usefulness of b value threshold (b) map in the evaluation of rectal adenocarcinoma by comparing it with diffusion-weighted images and ADC maps regarding lesion detection and the prediction of pathological features.

Materials And Methods: Thirty-five patients with rectal tumors were enrolled and underwent axial DWI using a 3-Tesla MRI system. Contrast-to-noise ratio (CNR) between the lesions and normal tissues were assessed on the diffusion-weighted images and b maps.

The Effect of the Yingyangbao Complementary Food Supplement on the Nutritional Status of Infants and Children: A Systematic Review and Meta-Analysis.

Yingyangbao (YYB) is a nutrient-dense complementary food supplement for infants and young children in China. There has been considerable interest and research on the potential effects of YYB on hematological and anthropometric outcomes in China, but limited effort has been made to consolidate and synthesize the evidence to inform the research and policy agendas. Eight English databases and three Chinese databases were searched from January 2001 to June 2019 to identify YYB intervention studies.

The prognostic value of the lymphocyte-to-monocyte ratio for high-risk papillary thyroid carcinoma.

Background And Aims: The prognosis of papillary thyroid carcinoma (PTC) is highly variable, even for high-risk cases. The predictive and prognostic role of the lymphocyte-to-monocyte ratio (LMR) has been reported in other cancers. The aim of our present study was to explore the value of LMR prognostic prediction in high-risk PTC patients.

Tracking development assistance for reproductive, maternal, newborn, child and adolescent health in conflict-affected countries.

Background: Little is known about the patterns of development assistance (DA) for each component of reproductive, maternal, newborn, child and adolescent health (RMNCAH) in conflict-affected countries nor about the DA allocation in relation to the burden of disease.

Methods: We tracked DA to RMNCAH in general and to each of its four components: reproductive health (RH), maternal and newborn health (MNH), child health (CH) and adolescent health (AH), in 25 conflict-affected countries between 2003 and 2017. We compared DA and disability-adjusted life years (DALYs) for each component.

Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism.

Previous studies reported increased expression and activity of neutrophil elastase (NE) in NASH. However, the role of NE in nonalcoholic steatohepatitis (NASH) remained unclear. Wild type (WT) and NE knockout (NE KO) mice were fed with western diet (WD) for 24 weeks to establish NASH model.

Tuned Local Surface Potential of Epoxy Resin Composites by Inorganic Core-Shell Microspheres: Key Roles of the Interface.

Designing and controlling the interface interaction between polymer and filler is a challenge for nanocomposite insulation materials with the enhanced insulating and thermal conductive properties simultaneously. Meanwhile, the roles of the interface in the charge distribution of the composite on the macroscale are well studied. However, the effects of the interface on the nanoscale are not clear.

Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis.

T helper 17 (Th17) cells are regarded as key factors in the pathogenesis of multiple sclerosis (MS). Although the involvement of certain microRNAs (miRNAs) in the development of MS has been reported, their roles in Th17 cell differentiation and MS pathogenesis remain elusive. In this study, we identified that let-7f-5p expression is significantly downregulated in CD4 T cells from MS patients and during the process of Th17 differentiation.

Low circulating levels of vitamin D may contribute to the occurrence of preeclampsia through deregulation of Treg /Th17 cell ratio.

Problem: Studies assessing the association between vitamin D deficiency and preeclampsia (PE) have not reached a consensus. The study aimed to investigate the role of vitamin D in the occurrence of PE through its immune-modulatory effects on Treg/Th17 cell ratio.

Method Of Study: This is a case-control study of third-trimester pregnant women.

Compositional and Functional Analysis of the Microbiome in Tissue and Saliva of Oral Squamous Cell Carcinoma.

Oral squamous cell carcinoma (OSCC) is affected by the interaction between oral pathogen and holobionts, or the combination of the host and its microbial communities. Studies have indicated the structure and feature of the microbiome in OSCC tissue and saliva, the relationships between microbiota and OSCC sites, stages remain unclear. In the present study, OSCC tissue (T), saliva (S) and mouthwash (W) samples were collected from the same subjects and carried out the microbiome study by 16S sequencing.

MicroRNA expression profile is altered in the upper airway skeletal muscle tissue of patients with obstructive sleep apnea-hypopnea syndrome.

Objective: To investigate the involvement of microRNAs (miRNAs) in the pathogenesis of obstructive sleep apnea-hypopnea syndrome (OSAHS).

Methods: In this study, we investigated miRNA profiles in the upper airway (UA) skeletal muscles of four patients with OSAHS and four matched controls using the miRCURY miRNA array. In another cohort of 12 OSAHS cases and 7 controls, the mRNA expression levels of interleukin (IL)-6 and Lin-28 homolog A (Lin28A), targets of the downregulated let-7 family members, were measured by real-time quantitative-PCR.

Effect of PVC film pretreatment on performance and lamination of wood-plastic composite plywood.

In order to solve the practical problem of heat transfer during the hot pressing process of a novel wood-plastic composite plywood, this paper investigates the perforation treatment of polyvinyl chloride (PVC) plastic films and their plywood composites. The PVC films were pretreated by the physical punching method, and the effects of PVC perforation diameter, hot pressing time and hot pressing temperature on the mechanical properties of the plywood composites were investigated by orthogonal experimental design. The results showed that the optimum hot pressing time was 7 min, the hot pressing temperature was 170 °C, and the PVC perforation diameter was 15 mm for the optimum mechanical properties.

[Extremely low frequency electromagnetic radiation enhanced energy metabolism and induced oxidative stress in Caenorhabditis elegans].

The aim of this study was to determine the effects of extremely low frequency electromagnetic field (ELF-EMF) on energy metabolism and oxidative stress in Caenorhabditis elegans (C. elegans). Worms in three adult stages (young adult stage, egg-laying stage and peak egg-laying stage) were investigated under 50 Hz, 3 mT ELF-EMF exposure.

Identification of a novel COL4A5 mutation in the proband initially diagnosed as IgAN from a Chinese family with X-linked Alport syndrome.

Alport syndrome (AS) is a hereditary progressive nephropathy characterized by hematuria, ultrastructural lesions of the glomerular basement membrane, ocular lesions and sensorineural hearing loss. Germline mutations of COL4A5 are associated with X-linked AS with an extreme phenotypic heterogeneity. Here, we investigated a Chinese family with Alport syndrome.

Green synthesis of benzonitrile using ionic liquid with multiple roles as the recycling agent.

Preparation of benzonitrile from benzaldehyde and hydroxylamine hydrochloride is one of the most advantageous approaches. Nevertheless, it suffers from various constraints such as longer reaction time, corrosion and recovery of hydrochloric acid, the use of metal salt catalysts and their separation. For these reasons, a novel green benzonitrile synthetic route was proposed with ionic liquid as the recycling agent in this study.

Clinicopathological characteristics and recurrence risk of papillary thyroid microcarcinoma in the elderly.

The optimal management for elderly patients with papillary thyroid microcarcinoma (PTMC) is not well established. The aim of the present study is to describe the clinicopathological characteristics and identify predictors of recurrence in the elderly PTMC patients. We conducted a retrospective study of PTMC patients who underwent thyroidectomy.

CD22 CAR T-cell therapy in refractory or relapsed B acute lymphoblastic leukemia.

Despite worldwide promising clinical outcome of CD19 CAR-T therapy, relapse after this therapy is associated with poor prognosis and has become an urgent problem to be solved. We conducted a CD22 CAR T-cell therapy in 34 relapsed or refractory (r/r) B-ALL pediatric and adult patients who failed from previous CD19 CAR T-cell therapy. Complete remission (CR) or CR with incomplete count recovery (CRi) was achieved in 24 of 30 patients (80%) that could be evaluated on day 30 after infusion, which accounted for 70.