FOXQ1 inhibits the progression of osteoarthritis by regulating pyroptosis.

Background: Osteoarthritis (OA) is the most common age-related joint disease, and the NLRP3-induced pyroptosis has been demonstrated in its progression. The upstream molecules or specific mechanisms controlling NLRP3 and pyroptosis in OA remain unclear.

Methods: Transcriptome sequencing was performed in the OA mice model, and the expression levels of differentially expressed genes were assessed by qRT-PCR.

Stability limits for modes held in alternating trapping-expulsive potentials.

We elaborate a scheme of trapping-expulsion management (TEM), in the form of the quadratic potential periodically switching between confinement and expulsion, as a means of stabilization of two-dimensional dynamical states against the backdrop of the critical collapse driven by the cubic self-attraction with strength g. The TEM scheme may be implemented, as spatially or temporally periodic modulations, in optics or BEC, respectively. The consideration is carried out by dint of numerical simulations and variational approximation (VA).

CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, and fibroblast-like synoviocytes (FLSs) are key effector cells in RA development. Mounting evidence indicates that circular RNAs (circRNAs) participate in the occurrence and development of RA. However, the precise mechanism of circRNA mitogen-activated protein kinase (circMAPK9) in the cell processes of FLSs has not been reported.

Hsa_circ_0044235 regulates the pyroptosis of rheumatoid arthritis via MiR-135b-5p-SIRT1 axis.

Studies have found that cell pyroptosis is involved in the occurrence and development of rheumatoid arthritis (RA). Hsa_circ_0044235 has been found to be significantly low-expressed in RA patients. The purpose of this research was to reveal the regulatory mechanism of hsa_circ_0044235 in the pyroptosis pathway of RA.

Andrographolide mitigates cartilage damage via miR-27-3p-modulated matrix metalloproteinase13 repression.

Background: As a potential anti-arthritic agent, Andrographolide (And) is capable of promoting chondrocyte proliferation and preventing apoptosis in pathologic condition. The present study aimed to explore the roles of And in in vivo and in vitro models of osteoarthritis (OA), as well as its underlying molecular mechanisms.

Methods: An OA mouse model was established using anterior cruciate ligament transection operation on the left knee joint.

PHACTR1 gene polymorphism with the risk of coronary artery disease in Chinese Han population.

Background: Coronary artery disease (CAD) is the most frequent multifactorial disease worldwide and is characterised by endothelial injury, lipid deposition and coronary artery calcification. The purpose of this study was to determine the allelic and genotypic frequencies of two loci (rs2026458 and rs9349379) of phosphatase and actin regulator 1 (PHACTR1) to the risk of developing CAD in the Chinese Han population.

Methods: A case-control study was conducted including 332 patients with CAD and 119 controls.

Red cell distribution width in coronary heart disease: prediction of restenosis and its relationship with inflammatory markers and lipids.

Background: Red cell distribution width (RDW) is associated with a poor prognosis and adverse events in cardiovascular diseases. The aims of this study were to investigate the relationship between serum RDW levels and outcomes after percutaneous coronary intervention and to identify potential novel laboratory markers for evaluating the risk of in-stent restenosis (ISR) with stable angina pectoris.

Methods: A total of 261 patients with coronary heart disease from Dongfeng General Hospital implanted with a coronary drug-eluting stent (DES) were enrolled in the study.