Intradermal Injection of Oxytocin Aggravates Chloroquine-Induced Itch Responses Activating the Vasopressin-1a Receptor/Nitric Oxide Pathway in Mice.

Oxytocin (OT), a hormone synthesized within the paraventricular nucleus and supraoptic nucleus of the hypothalamus, when given intracerebroventricularly, induces strong scratching behaviors. However, it is not clear whether intradermal injection (ID) of OT elicits itch sensation. Herein, we found that OT (0.