Abnormalities in male gametophytes development responsible for low seed set of Peudosasa subsolida.

Pseudosasa subsolida belongs to the Pseudosasa genus within the Poaceae family. Due to its unique flowering cycle and the physiological traits associated with asexual reproduction, acquiring floral material from P. subsolida is particularly challenging.

Intra-arterial tenecteplase after successful endovascular recanalisation in patients with acute posterior circulation arterial occlusion (ATTENTION-IA): multicentre randomised controlled trial.

Objective: To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation.

Design: Multicentre randomised controlled trial.

Setting: 31 hospitals in China, 24 January 2023 to 24 August 2023.

Effects of admission hyperglycemia and intravenous thrombolysis allocation in acute basilar artery occlusion after endovascular treatment: Analysis of the ATTENTION registry.

This study was to investigate the admission hyperglycemia and modified effect of intravenous thrombolysis (IVT) on clinical outcomes in acute basilar artery occlusion (BAO) patients receiving endovascular treatment (EVT). We prospectively recruited acute BAO patients from 48 stroke centers across 22 Chinese provinces in the ATTENTION registry from 2017 to 2021. Hyperglycemia on admission was defined as glucose ≥7.

A Novel Bifunctional μOR Agonist and σR Antagonist with Potent Analgesic Responses and Reduced Adverse Effects.

Bifunctional ligands possessing both μOR agonism and σR antagonism have shown promise in producing strong analgesic effects with reduced opioid-related side effects. However, the μOR agonism activity of most dual ligands diminishes compared with classical opioids, raising concern about their effectiveness in managing nociceptive pain. In this study, a new class of dual μOR agonist/σR antagonist was reported.

Overwintering performance of bamboo leaves, and establishment of mathematical model for the distribution and introduction prediction of bamboos.

Bamboo has great economic values and is used extensively in many industries, and their natural distribution range was divided into 12 zones in China according to the temperature of their geographical distribution in previous works. Different bamboo species had significantly different abilities in low-temperature tolerance, which need to be considered carefully during ex-situ introduction. In this paper, we observed and evaluated the low-temperature damage of 19 bamboo species in winter, and measured the physiological changes of bamboo leaves.

Algorithms Research and Precision Comparison of Different Frequency Combinations of BDS-3\GPS\Galileo for Precise Point Positioning in Asia-Pacific Region.

With the continuous construction and development of the BeiDou navigation satellite system (BDS), its positioning performance is constantly being improved. In this study, the positioning performance of different frequency combinations of BDS-3/GPS/Galileo in the Asia-Pacific region was investigated. The precision products of Wuhan University and the observation data of nine MGEX stations were selected to compare and analyze the B1I\B1C\B2a\B3I and L1\E1 pseudo-range Standard Point Positioning (SPP) and B1IB2a\B1IB3I\B1CB2a\B1CB3I\B2aB3I\L1L2\E1E5a precise point positioning (PPP) performance, while B1I\B3I\L1 SPP and B1IB3I PPP were investigated using BDS-2 with QZSS supplemented with BDS-3 and GPS.

Plasticity in the Morphology of Growing Bamboo: A Bayesian Analysis of Exogenous Treatment Effects on Plant Height, Internode Length, and Internode Numbers.

Sucrose (Suc) and gibberellin (GA) can promote the elongation of certain internodes in bamboo. However, there is a lack of field studies to support these findings and no evidence concerning how Suc and GA promote the plant height of bamboo by regulating the internode elongation and number. We investigated the plant height, the length of each internode, and the total number of internodes of Moso bamboo () under exogenous Suc, GA, and control group (CTRL) treatments in the field and analyzed how Suc and GA affected the height of Moso bamboo by promoting the internode length and number.

Saliva diagnostics: emerging techniques and biomarkers for salivaomics in cancer detection.

Introduction: The pursuit of easy-to-use, non-invasive and inexpensive diagnostics is an urgent task for clinicians and scientists. Saliva is an important component of body fluid with regular changes of contents under various pathophysiological conditions, and the biomarkers identified from saliva shows high application potentials and values in disease diagnostics. This review introduces the latest developments in saliva research, with an emphasis on the detection and application of salivary biomarkers in cancer detection.

A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i).

The disruption of copper homeostasis (Cu/Cu) may cause neurodegenerative disorders. Thus, the need for understanding the role of Cu in physiological and pathological processes prompted the development of improved methods of Cu analysis. Herein, a new near-infrared (NIR) fluorescent turn-on probe (NPCu) for the detection of Cu was developed based on a Cu-mediated benzylic ether bond cleavage mechanism.

STC1 ameliorates cognitive impairment and neuroinflammation of Alzheimer's disease mice via inhibition of ERK1/2 pathway.

Objective: To investigate the regulatory role of STC1 (Stanniocalcin-1) mediated ERK1/2 pathway in cognitive impairment and neuroinflammation of Alzheimer's disease (AD).

Methods: WT mice and STC1 Tg mice (transgenic overexpression of STC1) were used to establish AD models to perform behavioral test by Morris water maze. Hippocampal cell apoptosis was quantified by TUNEL staining, the levels of inflammatory cytokines in serum and hippocampal tissues determined by ELISA, as well as oxidative stress-related factors detected by corresponding testing kits, and protein expression of STC1 and ERK1/2 pathway measured by Western blotting.

The atypical binding mechanism of second calcium on phospholipase A2 group IIE.

Secreted phospholipase A2s (sPLA2s) are calcium dependent enzymes involved in various biological events such as lipid metabolism and inflammation. We previously identified the second calcium (Ca2) binding site of human sPLA2 Group IIE (hGIIE) by structural study and suggested that Asn21 act as the switch of Ca2 binding to modulate the enzymatic activity, but the detailed Ca2 binding mechanism is still unclear. Combined with enzymatic assay, model analysis and calcium binding affinity data for mutated hGIIE proteins, we herein further demonstrate that the flexibly bound Ca2 is essential for the catalysis of hGIIE, unlike the stable binding of Ca2 in hGIIA that replenishes the calcium in the typical loop during the reaction.

Association between carotid intima media thickness and small dense low-density lipoprotein cholesterol in acute ischaemic stroke.

Background: Intima-media thickness (IMT) and small dense low-density lipoprotein cholesterol (sdLDL-C) have been reported to be related to atherosclerosis and stroke. This study is trying to explore the association between IMT and sdLDL-C in Chinese acute ischaemic stroke (AIS) subjects.

Methods: This study enrolled total 368 consecutive AIS patients and 165 non-AIS controls from November 2016 to February 2019.

Association of Small Dense Low-Density Lipoprotein Cholesterol with Stroke Risk, Severity and Prognosis.

Aim: To investigate the association of small dense low-density lipoprotein cholesterol (sdLDL-C) and acute ischemic stroke (AIS) in terms of risk, severity, and outcomes. Prediction models were established to screen high-risk patients and predict prognosis of AIS patients.

Methods: We enrolled in this study 355 AIS patients and 171 non-AIS controls.

The Effect of Intensive Statin Therapy on Symptomatic Intracranial Arterial Stenosis.

Background: The aim of this study was to observe the effect of intensive statin therapy on symptomatic intracranial arterial stenosis.

Methods: overall, 120 patients with symptomatic intracranial arterial stenosis were admitted to the Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China from January 2010 to May 2013.

The association of hormone signalling genes, transcription and changes in shoot anatomy during moso bamboo growth.

Moso bamboo is a large, woody bamboo with the highest ecological, economic and cultural value of all the bamboo types and accounts for up to 70% of the total area of bamboo grown. However, the spatiotemporal variation role of moso bamboo shoot during growth period is still unclear. We found that the bamboo shoot growth can be divided into three distinct periods, including winter growth, early growth and late growth based on gene expression and anatomy.

Efficacy and safety of intensive statin therapy in Chinese patients with atherosclerotic intracranial arterial stenosis: a single-center, randomized, single-blind, parallel-group study with one-year follow-up.

Objectives: The purpose of this study is to validate the efficacy of intensive statin therapy for patients with atherosclerotic intracranial arterial stenosis (AICAS).

Methods: In this study, we performed a single-center, randomized, single-blind, parallel-group clinical trial. A total of 120 Chinese patients with AICAS were enrolled and randomly divided into three groups [low-dose atorvastatin therapy (LAT, 10mg/day), standard-dose atorvastatin therapy (SAT, 20mg/day), and intensive-dose atorvastatin therapy (IAT, 40mg/day) groups] in a 1:1:1 ratio.

[Effect of adenovirus-mediated mutant exogenous P27kip1 gene expression on the chemosensitivities of cholangiocarcinoma cell line].

Objective: To investigate the effects of mutant exogenous P27(kip1) gene on chemosensitivity of human cholangiocarcinoma cell line.

Methods: The recombinant vector was constructed and the mutant P27(kip1) gene was transfected into human cholangiocarcinoma cell line (QBC(939)). RT-PCR and Western blot were used to determine the expression of target genes.