Publications by authors named "Zhihua Cai"

An organocatalytic method for the SuFEx click reaction of gaseous SOF is described. Different organic bases such as DBU, TBD, triethylamine and Hünig's base can efficiently catalyze the SuFEx of SOF with various phenols to produce aryl fluorosulfates in 61-97% yields. Under the same conditions, pyridone, pyrazolone and amines can also react with SOF to afford the corresponding heteroaryl fluorosulfates or sulfamoyl fluorides in good yields.

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Carboxylic acids are attractive synthetic feedstocks with stable, non-toxic, and inexpensive properties that can be easily obtained from natural sources or through synthesis. Carboxylic acids have long been considered environmentally friendly coupling agents in various organic transformations. In recent years, electrochemically mediated decarboxylation reactions of decarboxylic acids and their derivatives (NHPI) have emerged as effective new methods for constructing carbon-carbon or carbon-heterocarbon chemical bonds.

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An aryne-promoted dehydrosulfurization reaction of thioamides to give nitriles and diaryl sulfides in a one-pot manner is presented. Aromatic, heteroaromatic, and aliphatic natural products and drug-derived nitriles and diaryl sulfides were obtained in good to excellent yields. Especially, selenoamide was also a suitable substrate and produced diaryl selenide and nitrile in high yields.

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Platinum-based neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has been proposed as an alternative treatment approach for cervical cancer (CC) in stage Ib2-IIb, who had a strong desire to be treated with surgery. Our study aims to develop a model based on multimodal MRI by using radiomics and deep learning to predict the treatment response in CC patients treated with neoadjuvant chemoradiotherapy (NACRT). From August 2009 to June 2013, CC patients in stage Ib2-IIb (FIGO 2008) who received NACRT at Fujian Cancer Hospital were enrolled in our study.

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A direct and practical three-component tandem reaction of arynes, -methyl- sulfonothioate with sulfonamides or amides is developed. The reaction is highly efficient and chemoselective, which allows mild synthesis of trideuteromethylated sulfilimines with broad substrate scope and good functional group compatibility, giving the products in good to excellent yields with 92%-99% deuterium incorporation. Mechanism studies disclosed sulfenamide that generated in is the key intermediate for the reaction.

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In this work, a facile and efficient method for the synthesis of sulfilimines through multicomponent reaction of arynes, sulfamides, and thiosulfonates was developed. A variety of structurally diverse substrates and functional groups were very compatible in the reaction, giving the corresponding sulfilimines in good to high yields. This protocol could be conducted on a gram scale, and the product was easily converted to sulfide and sulfoximine.

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Using a simulation based method, this paper analysis the damage effect of blast wave and fragments on human body and the protective effect of bulletproof vest. The results show that compared with the single blast shock wave, the chest injury is more serious under the combined action of blast shock wave and fragments. The peak stress of sternum, costal cartilage and rib increases by 334.

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Unlocking the biomechanical effects of cervical spine positioning rotation manipulation in the treatment of patients with neck pain. In this paper, the safety of the cervical positioning rotation manipulation is analyzed by experimentally obtaining head kinematic data, importing them into a finite element model that has been developed and validated, and calculating and analyzing the angular displacements, disc pressures, and articular surface contact forces in the normal and pathological models. The results show that the cervical spine positioning rotation technique is more effective in adjusting the position and applying force to the cervical spine C5-C6 "tendon out of the groove and bone misalignment" pathological model.

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Protective equipment in war plays a vital role in the safety of soldiers, the threat to soldiers from brain damage caused by deformation at the back of the helmet cannot be ignored, so research on reduce blunt post-cranial injury has great significance and value. This study first conducted gunshot experiments, used rifle bullets impact bulletproof plate and different density liner foam to record the incident process and internal response of craniocerebral model. After verifying the accuracy of finite element model through experimental data, optimization model is established based on response surface method to optimize the structure of gradient foam, analyze the cranial strain and energy absorption to select the best density and thickness distribution of each foam layer.

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Explosion overpressure propagates extracranially and causes craniocerebral injury after being transmitted into the brain. Studies on the extent of skull to reduce impact overpressure are still lacking. Therefore, it is necessary to study the relationship between intracranial pressure (ICP) and external field pressure and the situation of craniocerebral injury under the blast wave.

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The organic superbase -Bu-P-catalyzed direct thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates was developed. Yields of perfluorophenylsulfides of up to 97% under catalysis of 5 mol% -Bu-P were achieved. This method was shown to provide an efficient way to construct the perfluorophenyl-sulfur bond under mild metal-free reaction conditions.

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Background: Several studies have reported the combination of intracavity or cervical lymph node hyperthermia with chemoradiotherapy (CRT) to improve clinical outcomes in nasopharyngeal carcinoma (NPC), but the combination with whole-body hyperthermia (WBH) for treating NPC is unexplored. We aimed to assess the efficacy of the combination of radiotherapy, chemotherapy and WBH in patients with locoregionally advanced NPC.

Methods: Between July 2008 and November 2012, 239 newly diagnosed NPC patients were enrolled in a pre-propensity score-matched cohort, including 193 patients who received CRT (CRT group) and 46 who underwent CRT with WBH (HCRT group).

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Soldiers suffer from multiple explosions in complex battlefield environment resulting in aggravated brain injuries. At present, researches mostly focus on the damage to human body caused by single explosion. In the repetitive impact study, small animals are mainly used for related experiments to study brain nerve damage.

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A mild and transition-metal-free benzannulation reaction for the construction of the naphthalene skeleton has been described. Benzynes react with α-cyano-β-alkylenones through a tandem nucleophilic addition/cyclization/aromatization process to afford polysubstituted naphthalenes in 50-94% yields.

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Hepatocellular carcinoma (HCC) has a dismal long-term outcome. We aimed to construct a multi-gene model for prognosis prediction to inform HCC management. The cancer-specific differentially expressed genes (DEGs) were identified using RNA-seq data of paired tumor and normal tissue.

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The first synthesis of benzyne-derived stable zwitterions is reported. Benzynes generated from 2-(trimethylsilyl)aryl triflates undergo a multicomponent reaction with phosphines and CO to produce the stable 1,5-zwitterionic species in moderate to excellent isolated yields, which provides a novel method for the preparation of phosphonium inner salts under mild and transition-metal-free conditions.

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The mechanism of Behind Helmet Blunt Trauma (BHBT) caused by a high-speed bullet is difficult to understand. At present, there is still a lack of corresponding parameters and test methods to evaluate this damage effectively. The purpose of the current study is therefore to investigate the response of the human skull and brain tissue under the loading of a bullet impacting a bullet-proof helmet, with the effects of impact direction, impact speed, and impactor structure being considered.

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Hyperspectral image (HSI) consists of hundreds of narrow spectral band components with rich spectral and spatial information. Extreme Learning Machine (ELM) has been widely used for HSI analysis. However, the classical ELM is difficult to use for sparse feature leaning due to its randomly generated hidden layer.

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Background: Severe kyphotic deformity can affect the quality of life of the elderly and is commonly treated by an osteotomy. Considering that the elderly often suffer from osteoporosis, the safety and efficacy of internal fixation are particularly important. The aim of this study was to analyse the effect of osteoporosis on internal fixation after spinal osteotomy.

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Background: Vertebral column decancellation (VCD) is a new spinal osteotomy technique to correct thoracolumbar kyphotic deformity (TLKD). Relevant biomechanical research is needed to evaluate the safety of the technique and the fixation system. We aimed to develop an accurate finite element (FE) model of the spine with TLKD following VCD and to provide a reliable model for further biomechanical analysis.

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An unprecedented Rh(I)-catalyzed, amino-group-assisted C-H carboxylation of 2-arylanilines with CO under redox-neutral conditions has been developed. This reaction was promoted by a phosphine ligand with t-BuOK as the base and did not require the use of additional strong organometallic reagent. It enabled an efficient direct conversion of a broad range of 2-(hetero)arylanilines including electron-deficient heteroarenes to various phenanthridinones.

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With the direct input-output connections, a random vector functional link (RVFL) network is a simple and effective learning algorithm for single-hidden layer feedforward neural networks (SLFNs). RVFL is a universal approximator for continuous functions on compact sets with fast learning property. Owing to its simplicity and effectiveness, RVFL has attracted significant interest in numerous real-world applications.

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To better understand head injuries, human head finite element (FE) models have been reported in the literature. In scenarios where the head is directly impacted and measurements of head accelerations are not available, a high-quality skull model, as well as a high-quality brain model, is needed to predict the effect of impact on the brain through the skull. Furthermore, predicting cranial bone fractures requires comprehensively validated skull models.

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Objective: To develop finite element models of spine following osteotomy and evaluate the effect of number and location of cross-links (CLs) on long-segment instrumentation.

Methods: A finite element model of instrumented spine following osteotomy was created from computed tomography images of a postoperative male patient with thoracolumbar kyphotic deformity. Five fixation models were established to simulate different number and location of CLs.

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A protocol of Pd(ii)-catalyzed, weak bidentate directing group assisted β-C(sp3)-H activation/cross-coupling with organoboron reagents has been achieved, affording arylation of aliphatic acid derivatives that contain α-hydrogen atoms in moderate to good yields. The potential of this method for an asymmetric β-C(sp3)-H arylation via desymmetrization was also presented.

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