Publications by authors named "Zhihong Xu"

Article Synopsis
  • Current treatments for acute myeloid leukemia (AML) face challenges due to side effects and resistance issues.
  • This study explores the anticancer potential of extracts from the edible mushroom Cantharellus cibarius on the MV4-11 AML cell line.
  • A specific fraction, LH-20F-IV, demonstrated the highest inhibitory effect on the leukemia cells, indicating the mushroom may contain promising anticancer compounds.
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  • Peroxynitrite (ONOO) is a reactive molecule linked to various diseases, prompting the need for effective detection methods.
  • A new ratiometric fluorescence probe was developed for ONOO detection, featuring a boronate group and emitting distinct signals at 615 nm and 475 nm upon ONOO exposure.
  • The probe showed high sensitivity and selectivity with a low detection limit (11 nM) and demonstrated successful applications in imaging biological systems like live cells and zebrafish.
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Salinization is recognized as a global problem, restricting agricultural production and sustainability. Targeting the salinity-induced oxidative stress, antioxidant treatment represents a protective strategy to improve plant salt tolerance. Herein, we report a VC MXene nanozyme (MXenzyme), which exhibits good biocompatibility and excellent reactive oxygen species scavenging activity to ameliorate the salt stress-induced inhibition of seed germination.

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Monitoring peroxynitrite (ONOO) fluctuations is particularly important for assessing pathological progression and oxidative damage due to their crucial role in maintaining the redox balance of organisms. However, due to the lack of efficient tools for differentially monitoring ONOO fluctuations at different concentration ranges in vivo, the precise detection of endogenous ONOO fluctuations under pathological conditions in living systems remains challenging. Herein, we rationally designed a double-enhanced emission cascade activatable near-infrared (NIR) fluorescent probe () for the measurement of ONOO, which consists of a borate ester response group and a malononitrile hemicyanine fluorophore.

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  • - The study evaluates the effectiveness of the Caprini score and D-dimer levels as predictors for post-operative deep vein thrombosis (DVT) risk in patients undergoing primary total knee arthroplasty (TKA), noting their greater reliability prior to surgery.
  • - With data from 2,873 patients, findings revealed that 10.55% developed DVT post-surgery, with significant variations based on Caprini scores and D-dimer levels; higher scores and levels were associated with increased DVT incidence.
  • - The research suggests that patients with lower pre-operative scores and D-dimer levels have a significantly lower risk of developing DVT, while those with higher scores and levels experience a considerably higher risk,
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  • Rapid detection of glyphosate (GLP) is crucial for monitoring environmental pollution and human health risks.
  • This study develops carbon dots nanozymes (CDszymes) through a quick microwave method using expired drugs, which exhibit peroxidase-like activity for detecting GLP.
  • The detection methods achieved limits as low as 0.02 ng/mL for fluorescence, and the process is demonstrated using fruits and vegetables, highlighting a sustainable approach to utilizing expired medications.
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Tire wear particles (TWPs) have been an emerging threat to the soil ecosystem, while impact of the TWPs aging on soil microbial communities remains poorly understood. This study investigated the dynamic responses of soil microbial communities to the TWPs aging under both wet and flooded conditions. We found that different soil moisture conditions resulted in distinct microbial community structures.

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Single-atom nanozymes have garnered significant attention due to their exceptional atom utilization and ability to establish well-defined structure-activity relationships. However, conventional pyrolytic synthesis methods pose challenges such as high energy consumption and random local environments at the active sites, while achieving non-pyrolytic synthesis of single-atom nanozymes remains a formidable technical hurdle. The present study focuses on the synthesis of laccase-like iron-based single-atom nanozymes (Fe-SAzymes) using a non-pyrolysis method facilitated by microwave irradiation.

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Background: Gap tension is an important factor influencing the clinical outcomes of total knee arthroplasty (TKA). Traditional mechanical alignment (MA) places importance on neutral alignment and often requires additional soft tissue releases, which may be related to patient dissatisfaction. Conversely, the functional alignment requires less soft tissue release to achieve gap balance.

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Sustaining the development of rural and pastoral communities' hinges on livelihood resilience. Pastoralist household resilience relies on resource availability and decision-making abilities. Despite extensive studies on pastoralist livelihoods, a significant knowledge gap remains in understanding the nuanced adaptive capacities of diverse households, particularly amid grassland degradation.

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To evaluate the impact of neoadjuvant chemotherapy on perioperative immune function in breast cancer patients, focusing on CD3, CD4, CD8, and natural killer (NK) cells, as well as the CD4/CD8 ratio. We retrospectively reviewed medical records of breast cancer patients who underwent surgery with or without neoadjuvant chemotherapy at our medical center from January 2020 to December 2022. Patients were matched 1:1 based on propensity scores.

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Iron-anchored nitrogen/doped carbon single-atom nanozymes (Fe-N/C), which possess homogeneous active sites and adjustable catalytic environment, represent an exemplary model for investigating the structure-function relationship and catalytic activity. However, the development of pyrolysis-free synthesis technique for Fe-N/C with adjustable enzyme-mimicking activity still presents a significant challenge. Herein, Fe-N/C anchored three carrier morphologies were created via a pyrolysis-free approach by covalent organic polymers.

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Purpose: Early ambulation is an important step in accelerating post-joint replacement surgery recovery. However, there is limited research on populations who are unable to walk immediately after the operation. The purpose of this study was to determine the factors influencing postoperative ambulation in total knee arthroplasty (TKA) patients.

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The Golgi apparatus is an essential organelle constructed by the stacking of flattened vesicles, that is widely distributed in eukaryotic cells and is dynamically regulated during cell cycles. It is a central station which is responsible for collecting, processing, sorting, transporting, and secreting some important proteins/enzymes from the endoplasmic reticulum to intra- and extra-cellular destinations. Golgi-specific fluorescent probes provide powerful non-invasive tools for the real-time and visualization of the temporal and spatial fluctuations of bioactive species.

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As one of endogenous reactive oxygen species (ROS), peroxynitrite (ONOO) performs various functions in both pathological and physiological mechanisms. In this work, an optical and near-infrared (NIR) fluorescent probe (NX), which based on 3-dihydro-1H-xanthene and 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) group was designed and prepared to detect ONOO. This probe revealed an obvious optical and a fluorescent response when ONOO was present and it exhibited higher selectivity over other ROS.

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Partial nitrification-Anammox (PN-A) is a cost-effective, environmentally friendly, and efficient method for removing ammonia (NH-N) pollutants from water. However, the limited accumulation of nitrite (NO-N) represents a bottleneck in the development of PN-A processes. To address this issue, this study developed a composite carrier loaded with nano zero-valent iron (nZVI) and zeolite to enhance NO-N accumulation during short-cut nitrification.

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A retrospective study on 90 eligible HER2+ ductal carcinoma with microinvasion (DCIS-MI) patients was performed with a median follow-up time of 57 months. The baseline was consistent between the 4-cycle and 6-cycle chemotherapy groups. There were more patients with multiple foci of micrometastasis in the target therapy group in the two groups with or without target therapy ( < 0.

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Objective: To explore the impact of anemia on the incidence of perioperative lower limb deep vein thrombosis (DVT) in patients undergoing total hip arthroplasty (THA).

Methods: A retrospective analysis was conducted on clinical data of 1 916 non-fracture patients who underwent THA between September 2015 and December 2021, meeting the selection criteria. Among them, there were 811 male and 1 105 female patients, aged between 18 and 94 years with an average of 59.

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Thalassemia is most widely distributed single gene autosome recessive genetic disease in the world, whose clinical manifestation was changed from asymptomatic anemia to severe anemia requiring continous blood transfusion to maintain life, thus resulting in a serious economic burden to society and families. Therefore, it is necessary to carry out the corresponding prentatal screening and diagnosis. Most of the conventional detection methods can only detect the common thalassemia genotype, it can easy to cause misdiagnosis or missed diagnosis for those rate genetic variantions.

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Article Synopsis
  • Non-human primates (NHPs) are facing population declines due to various threats, including diseases caused by parasites, bacteria, and viruses.
  • Strongylid nematodes are common parasitic infections in NHPs, but their diversity is hard to study due to mixed infections not being distinguishable by traditional methods.
  • This study used advanced metagenomics techniques to analyze strongylid infections in NHPs from Malaysia and Japan, finding that the communities in Asian NHPs may be less diverse than those in African NHPs, providing key data for monitoring NHP health.
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Carbendazim residue has been widely concerned, and nitrous oxide (NO) is one of the dominant greenhouse gases. Microbial metabolisms are fundamental processes of removing organic pollutant and producing NO. Nitrification inhibitor 3,4-dimethylpyrazole phosphate (DMPP) can change soil abiotic properties and microbial communities and simultaneously affect carbendazim degradation and NO emission.

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Objective: To evaluate the accuracy and safety of the LANCET robotic system, a robot arm assisted operation system for total hip arthroplasty via a multicenter clinical randomized controlled trial.

Methods: A total of 116 patients were randomized into two groups: LANCET robotic arm assisted THA group (N = 58) and the conventional THA group (N = 58). General information about the patients was collected preoperatively.

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  • The study explores the potential benefits of moxibustion, a traditional Chinese medicine technique, in improving cardiorespiratory fitness (CRF) among healthy older adults, who often experience declines in fitness due to aging.
  • It employs a randomized trial with 126 participants divided into three groups: one receiving real moxibustion, one receiving sham treatment, and a control group with no intervention, over a period of 12 weeks.
  • The primary outcomes will measure changes in peak oxygen uptake and other fitness indicators, with the trial aiming to assess both the effectiveness and safety of the treatment.
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Small extracellular vesicles (sEVs) are cell-derived vesicles evolving as important elements involved in all stages of cancers. sEVs bear unique protein signatures that may serve as biomarkers. Pancreatic cancer (PC) records a very poor survival rate owing to its late diagnosis and several cancer cell-derived proteins have been reported as candidate biomarkers.

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