An efficient propagation system through stem cuttings of a multipurpose plant- Bur.

Bur., a versatile plant with medicinal, edible, landscaping, and ecological applications, holds significant economic value and boasts a long-standing history of utilization in China. Despite its robust adaptability, rapid growth, and extensive distribution, the current research gap concerning the physiological mechanisms underlying stem cutting propagation hampers the development of efficient strategies for commercial-scale propagation of , particularly for large-scale cultivation.

Non-lethal sampling of phalanges for heavy metal bioaccumulation in Pelophylax nigromaculatus from historical mercury mining areas in Southwestern China.

The Wanshan mercury mining area (WMMA) in Guizhou Province, China, has been identified as a region at high ecological risk owing to heavy metal contamination. This study employed non-lethal sampling methods, using the phalanges of Pelophylax nigromaculatus in the WMMA as analytical material. Ten heavy metal (metalloid) elements were selected for analysis, including Hg, Cr, Mn, Ni, Cu, Zn, Cd, Pb, As, and Se.

Extremely Large Anisotropy of Effective Gilbert Damping in Half-Metallic CrO.

Half-metals are a class of quantum materials with 100% spin polarization at the Fermi level and have attracted a lot of attention for future spintronic device applications. CrO is one of the most promising half-metal candidates for which the electrical and magnetic properties have been intensively studied in the last several decades. Here, we report the observation of a giant anisotropy (∼1600%) of effective Gilbert damping in the single-crystalline half-metallic (100)-CrO thin films, which is significantly larger than the values observed on conventional ferromagnetic Fe and CoFe thin films.

Comprehensive evaluation of the implementation of close-type county medical alliance in Shandong Province using entropy weight TOPSIS method and non-integer rank sum ratio method.

Background: To improve the capacity of county medical and health services, China encourages all localities to pilot the close-type county medical alliance. In Shandong Province, medical alliances have been piloted in 47 counties, ranking first in the country. The objective of this study is to comprehensively evaluate the implementation of close-type county medical alliance in Shandong Province, identify the differences between different county regions, and analyze the reasons, so as to provide a reference for the construction of a new county medical and health service system with clear goals, powers and responsibilities, and division of labor.

Rimegepant orally disintegrating tablet 75 mg for acute treatment of migraine in adults from China: a subgroup analysis of a double-blind, randomized, placebo-controlled, phase 3 clinical trial.

Background: Rimegepant orally disintegrating tablet (ODT), an oral small-molecule calcitonin gene-related peptide receptor antagonist, is indicated for acute and preventive treatment of migraine in the United States and other countries. Previously, a large clinical trial assessed the efficacy and safety of rimegepant ODT 75 mg for the acute treatment of migraine in adults living in China or South Korea. A post hoc subgroup analysis of this trial was performed to evaluate the efficacy and safety of rimegepant for acute treatment of migraine in adults living in China.

Transcutaneous electric acupoint stimulation reduced consumption of profopol in patients undergoing laparoscopic surgery: A randomized clinical trial.

Background: Propofol is a common regimen for general anesthesia maintenance. But propofol can dose-dependently generate cardiopulmonary depression. Thus, any strategy to reduce propofol dosage during laparoscopic surgery may have underlying beneficial effect for patient prognosis.

Association between postoperative nadir platelet count and postoperative cardiovascular complications following septal myectomy in patients with hypertrophic cardiomyopathy: a retrospective cohort study.

Background: Platelet count is associated with cardiovascular risk and mortality in several cardiovascular diseases, but the association of the nadir platelet counts post-septal myectomy with the cardiovascular complication risk in hypertrophic obstructive cardiomyopathy patients remains unclear.

Methods: This retrospective cohort study reviewed all adult patients who underwent septal myectomy at a single tertiary referral center over a 5-year period. Postoperative nadir platelet count was defined as the lowest platelet count in the first 4 postoperative days or until hospital discharge.

Effect of remimazolam vs propofol on emergence from general anesthesia in patients undergoing cerebral endovascular procedures: A randomized controlled, non-inferiority trial.

Study Objective: This study aimed to compare the time to emergence from general anesthesia with remimazolam versus propofol in patients undergoing cerebral endovascular procedures.

Design: A prospective, double-blind, randomized controlled, non-inferiority trial.

Setting: An academic hospital.

Association between depression status and hearing loss among older adults: The role of outdoor activity engagement.

Background: More than half of Chinese older adults over 60 are suffering from hearing loss, which might increase the risk of depression. Outdoor activity engagement is a key factor to alleviate depression symptoms. This study is conducted to analyze the associations between hearing loss and depression, and explore the role of outdoor activity engagement on depression.

The effect of four-phonon interaction on phonon thermal conductivity of hexagonal VTe and puckered pentagonal VTe.

The traditional view is that complex structures have lower lattice thermal conductivity. However, it is observed that complex structures have higher lattice thermal conductivity than simple atomic structures in VTe systems after considering the four-phonon scattering effect. In this work, we calculate the lattice thermal conductivity of an H-VTe monolayer with a simple atomic structure and that of a PP-VTe monolayer with a complex atomic arrangement using first-principles calculations combined with the Boltzmann transport theory under the conditions of with and without the four-phonon scattering process.

Association of intraoperative cerebral and somatic tissue oxygen saturation with postoperative acute kidney injury in adult patients undergoing multiple valve surgery.

Background: The association between tissue oxygenation with postoperative acute kidney injury (AKI) in adult patients undergoing multiple valve surgery has not been specifically studied.

Methods: In this prospective exploratory cohort study, 99 patients were enrolled. The left forehead, the left forearm, the left upper thigh, and the left renal region tissue oxygen saturation using near-infrared spectroscopy were monitored.

Low skeletal muscle mass as an early sign in children with fabry disease.

Background & Aims: Fabry disease (FD) is a rare X-linked metabolic storage disorder due to the deficiency of lysosomal α-galactosidase A which causes the accumulation of glycosphingolipids throughout the body. Underweight and low BMI have been occasionally reported in FD patients previously. Whether underweight is common in the early stage of FD and body composition analysis to determine the cause have not been reported.

Tuning the lattice thermal conductivity of SbTe by Cr doping: a deep potential molecular dynamics study.

Element doping is a prominent method for reducing the lattice thermal conductivity and optimizing the thermoelectric performance of materials in the thermoelectric field. However, determination of the thermal conductivity of element-doped systems is a challenging task, especially when the elements are randomly doped. In this work, a first-principles based deep neural network potential (NNP) is developed to investigate the lattice thermal transport properties of Cr-doped SbTe using molecular dynamics simulations.

Safety and efficacy of rimegepant orally disintegrating tablet for the acute treatment of migraine in China and South Korea: a phase 3, double-blind, randomised, placebo-controlled trial.

Background: No acute treatments targeting calcitonin gene-related peptide (CGRP) have been approved for use in China or South Korea. We aimed to compare the efficacy and safety of rimegepant-an orally administered small molecule CGRP antagonist-with placebo in the acute treatment of migraine among adults in these countries.

Methods: This double-blind, randomised, placebo-controlled, multicentre phase 3 trial was done at 86 outpatient clinics at hospitals and academic medical centres (73 in China and 13 in South Korea).

Early onset of nephrogenic diabetes insipidus due to fabry disease in a child with N215S mutation: Case report and literature review.

Background: Fabry disease (FD) is a rare X-linked lysosomal storage disorder. Renal involvement in FD is characterized by proteinuria and progressive renal decline. Reports on FD with nephrogenic diabetes insipidus as the initial manifestation are rare.

Acupuncture-related techniques for postoperative cognitive complications: a systemic review and meta-analysis.

Background: Postoperative cognitive complications are major challenges for postoperative recovery. Acupuncture-related techniques have been used for treating neurocognitive dysfunctions. However, whether they help to prevent postoperative cognitive complicationss remains unclear.

Integration of ATAC-Seq and RNA-Seq identifies key genes and pathways involved in the neuroprotection of S-adenosylmethionine against perioperative neurocognitive disorder.

The gene-regulatory landscape is highly dynamic in healthy and diseased brains. DNA methylation is a well-known epigenetic modification that regulates gene expression, and our previous study demonstrated that S-adenosylmethionine (SAM), a methylome modulator, was a neuroprotectant against perioperative neurocognitive disorder (PND). However, the underlying mechanism remains to be elucidated.

Pharmacokinetics and Safety of Single and Multiple Daily Dosing of 75-mg Rimegepant Orally Disintegrating Tablets in Healthy Chinese Adults: A Randomized Placebo-Controlled Trial.

Rimegepant is an oral small-molecule calcitonin gene-related peptide antagonist for acute migraine treatment with or without aura and prevention of episodic migraine in adults. This was a rimegepant single- and multiple-dose phase 1, randomized, placebo-controlled, double-blind study to evaluate the pharmacokinetics and confirm safety in healthy Chinese participants. Participants received a 75-mg rimegepant orally disintegrating tablet (ODT) (N = 12) or matching placebo (N = 4) ODT on days 1 and 3-7 after fasting for pharmacokinetic assessments.

Control and regulation of skyrmionic topological charge in a novel synthetic antiferromagnetic nanostructure.

Skyrmionium is a combination of a skyrmion with a topological charge ( is +1 or -1), resulting in a magnetic configuration with a total topological charge of = 0. Skyrmionium has distinctive characteristics, including a slightly higher velocity, motion restricted to the middle of the track without the skyrmion Hall effect (SkHE), and absence of an acceleration phase. However, there is little stray field due to the zero net magnetization, the topological charge is zero due to the magnetic configuration, and detecting skyrmionium is still challenging.

A severe complication of J-tip guide wire during catheterization: A case report and discussion.

J-tip guide wire entrapment within the heart is a serious and dangerous complication that is rarely mentioned. We present a case in which the J-tip guide wire was entrapped in the right atrium during tunneled cuffed venous catheterization. We were unable to remove the guide wire using previously reported methods and concluded with surgery.

Accessing the thermal conductivities of SbTe and BiTe/SbTe superlattices by molecular dynamics simulations with a deep neural network potential.

Phonon thermal transport is a key feature for the operation of thermoelectric materials, but it is challenging to accurately calculate the thermal conductivity of materials with strong anharmonicity or large cells. In this work, a deep neural network potential (NNP) is developed using a dataset based on density functional theory (DFT) and applied to describe the lattice dynamics of SbTe and BiTe/SbTe superlattices. The lattice thermal conductivities of SbTe are first predicted using equilibrium molecular dynamics (EMD) simulations combined with an NNP and the results match well with experimental values.

Transcutaneous electrical acupoint stimulation induced sedative effects in healthy volunteers: A resting-state fMRI study.

Background: Previous studies indicated the sedative effect of acupoint stimulation. However, its mechanism remains unclear. This study aimed to investigate the sedative effect of transcutaneous electrical acupoint stimulation (TEAS) and to explore the brain regions involved in this effect in healthy volunteers using functional magnetic resonance imaging (fMRI) techniques.

The high magnetoresistance performance of epitaxial half-metallic CrO-based magnetic junctions.

Half-metallic chromium dioxide (CrO) is an ideal spintronic material due to its near-full spin polarization and ultralow Gilbert damping at room temperature. Based on theoretical calculations, we found that the tunneling magnetoresistance (TMR) ratios of the CrO/XO/CrO (X= Ti and Sn) magnetic tunnel junctions (MTJs) can reach up to the order of magnitude of 10%, and the magnetoresistance (MR) ratio of CrO/RuO/CrO magnetic junctions (MJs) can reach the order of magnitude of 10%. In addition, we succeeded in fabricating epitaxial CrO-based MTJs (CrO/TiO/CrO and CrO/TiO/CoFeAl) with TiO tunnel barriers of varying thickness.