Publications by authors named "Zhiheng Ling"
Therapeutic antibodies or inhibitors targeting CSF-1R block colony stimulating factor-1/colony stimulating factor-1 receptor (CSF-1/CSF-R) signaling, and have shown remarkable efficacy in the treatment of cancer. However, little is known about tumor cell-intrinsic CSF-1R effects. Here, we show that human osteosarcomas contain CSF-1R-expressing cancer subpopulations, and demonstrate that osteosarcoma cell-intrinsic CSF-1R promotes growth in vitro and in vivo.
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- A rare case of fungal spondylodiscitis following H7N9 virus infection was reported, initially misdiagnosed as a vertebral tumor before being identified as fungal.
- Data from 77 cases of Candida and 94 cases of Aspergillus spondylodiscitis were analyzed, revealing that Candida infections generally have better outcomes (92.3% cure rate) compared to Aspergillus (70.2% cure rate).
- The study indicated that Candida is more commonly found in blood cultures and often treated with radical debridement, suggesting that early diagnosis and appropriate treatment significantly improve patient recovery.
Clinical significance of microRNA-130b in osteosarcoma and in cell growth and invasion.
Asian Pac J Trop Med
September 2015
Objective: To investigate clinical significance of microRNA-130b (miR-130b) in osteosarcoma and its role in cell growth and invasion.
Methods: miR-130b expression was detected in 68 samples of surgically resected osteosarcoma and matched normal tumor-adjacent tissues by qRT-PCR. The expression of miR-130b was altered by corresponding vectors in osteosarcoma cells, and then Western blot was used to detect the expression of PPARγ.
Objective: To evaluate the effect of down-regulation of Nav1.7 on the activation of astrocytes and microglia in DRG of rats with cancer pain, and explore the transmission of the nociceptive information.
Methods: Lentiviral vector harboring RNAi sequence targeting the Nav1.
Background: To date, the decision to treat multilevel cervical spondylotic myelopathy (CSM) with anterior cervical discectomy and fusion (ACDF) or anterior cervical corpectomy and fusion (ACCF) remains controversial. Therefore, we conducted a meta-analysis to quantitatively determine the efficacy of ACDF and ACCF in the treatment of multilevel CSM.
Methods: We searched several databases for related research articles published in English or Chinese.
Objective: To investigate the neuroprotective effects of rosiglitazone in a rat traumatic spinal cord injury (SCI) model.
Methods: Adult Sprague-Dawley rats (n = 12/group) underwent laminectomy (sham), SCI, SCI and rosiglitazone treatment (2 mg/kg twice daily for 7 days), or SCI and saline injection (vehicle). SCI was induced via dural application of an aneurysm clip.