Publications by authors named "Zhiheng Li"

Leukemia is characterized by multiple rearrangements of signal transduction genes and overexpression of nonmutated genes, such as transcription factors (TFs) genes. Super-enhancers (SEs) are prevalent in human cancers and are associated with the accumulation of numerous core TFs. SEs drive the expression of core TF genes by delivering robust transcriptional activation signals.

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In real soil environments, humus, colloids and other components significantly affect pollutant migration behavior. Investigating Tl(I) and kaolinite colloids' cotransport in quartz sand media containing sodium humate (HA-Na) is vital for comprehending Tl(I) migration underground. This study examined the migration of Tl(I) and kaolinite colloids across varying pH levels (5, 7), ionic strengths (ISs) (1, 5, 50 mmol/L), and kaolinite colloid concentrations.

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Background: Acute myeloid leukemia (AML) is a prevalent malignancy of the hematologic system. Despite advancements in therapeutic approaches, significant heterogeneity and therapeutic resistance pose substantial challenges to treatment. Tumors driven by core transcription factors through super-enhancers can establish core transcriptional regulatory circuits (CRCs) that modulate oncogene expression programs.

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Due to its similarity in hydrophobic properties to perfluorooctanesulfonic acid (PFOS), 6:2 fluorotelomer sulfonic acid (6:2 FTSA) has emerged as a key substitute for PFOS. Its presence in aquatic environments, along with the coexistence of polyethylene terephthalate (PET), may impact the growth of aquatic plants and ecosystem stability. This study explored the changes in antioxidant defense, photosynthetic system, and metabolic responses of water hyacinths (Eichhornia crassipes) under individual and combined exposure conditions.

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Antibiotic residues cause water contamination and disrupt aquatic ecosystems. Herein, we reported the fabrication of a novel Z-scheme heterojunction, MIL-88A(Fe)/TiC/MoO (MTO), for safe and efficient removal of antibiotics. TiC was introduced into the MIL-88A(Fe)/MoO (MO) heterojunction as an electronic mediator to accelerate charge separation.

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The gas chromatography-mass spectrometer(GC-MS) metabolomics method was used to investigate the anti-radiation effect of Yiguan Decoction water extract on mice and explore its related pathways and mechanisms of action. Healthy SPF male mice from Kunming were randomly assigned to six groups: blank group, model group, positive drug group, and high-dose, medium-dose, and low-dose groups of Yiguan Decoction, with ten mice in each group. Mice were prophylactically dosed for six days, and ~(60)Co γ ray with 5 Gy was used to establish a radiation mouse model.

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Silicosis is a life-threatening occupational disease because of inhaling silica dust, leading to chronic inflammation, pyroptosis, and fibrosis. Unfortunately, it is still lacking effective pharmacological intervention currently. Honokiol (HKL), a natural extract with biological activity from Magnolia bark, is known for its antioxidant and anti-inflammatory biological effects.

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Developing high-performance aqueous symmetric all-organic batteries (SAOBs) by replacing metal-based batteries or batteries with organic electrolytes is highly attractive to achieve a greener rechargeable world. However, such a new energy storage system still exhibits unsatisfactory rate capability and cycling stability due to the limitations in electrode materials screening. Here, a novel covalent organic framework (COF) containing abundant CN and CO for the electrode material is designed, which is combined with graphene and assembled into all-COF/graphene batteries for the first time.

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The direct use of readily available aldehydes as acyl radical precursors has facilitated diverse three-component acylative difunctionalization reactions of alkenes, offering a powerful route to synthesize β-branched ketones. However, asymmetric three-component acylative difunctionalization of alkenes with aldehydes still remains elusive. Here we report a copper-catalyzed asymmetric three-component radical acylarylation of vinylarenes with aldehydes and aryl boronic acids.

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Objective: The aim of this investigation is to explore the efficacy of combined exercise in elderly patients with hypertension. Moreover, we aim to delve into the underlying mechanisms governing blood pressure regulation, with the objective of promoting the adoption of this exercise regimen among elderly hypertensive individuals.

Methods: In our study, we conducted a thorough search across multiple databases, including PubMed, Web of Science, Cochrane Library, Embase, and Scopus.

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Elucidating mechanisms of T cell development can guide in vitro T cell differentiation from induced pluripotent stem cells (iPSCs) and facilitate off-the-shelf T cell-based immunotherapies. Using a stroma-free human iPSC-T cell differentiation platform, we screened for epigenetic modulators that influence T cell specification and identified the H3K9-directed histone methyltransferases G9a/GLP as repressors of T cell fate. We show that G9a/GLP inhibition during specific time windows of differentiation of hematopoietic stem and progenitor cells (HSPCs) skews cell fates toward lymphoid lineages.

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Efficient catalysts are imperative to accelerate the slow oxygen reaction kinetics for the development of emerging electrochemical energy systems ranging from room-temperature alkaline water electrolysis to high-temperature ceramic fuel cells. In this work, we reveal the role of cationic inductive interactions in predetermining the oxygen vacancy concentrations of 235 cobalt-based and 200 iron-based perovskite catalysts at different temperatures, and this trend can be well predicted from machine learning techniques based on the cationic lattice environment, requiring no heavy computational and experimental inputs. Our results further show that the catalytic activity of the perovskites is strongly correlated with their oxygen vacancy concentration and operating temperatures.

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Article Synopsis
  • Acute myeloid leukemia (AML) is a serious blood cancer that needs new treatment options, and this study highlights phosphodiesterase 3A (PDE3A) as a potential drug target.
  • Researchers found that PDE3A is overexpressed in AML cells compared to normal cells, and high levels of PDE3A are linked to worse outcomes for patients.
  • The study revealed that the PDE3A inhibitor anagrelide (ANA) can effectively suppress the growth of AML cells with high PDE3A levels, especially when used in combination with the chemotherapy drug idarubicin (IDA), which leads to enhanced anti-cancer effects through a process called pyroptosis.
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  • The traditional Markov Decision Process (MDP) framework in reinforcement learning assumes a static environment and stationary agent behavior, which is insufficient for real-time tasks due to its rigidity.
  • To tackle the issues of asynchronous decision-making and environment responses, methods like linear interpolation and state space augmentation are used, but they often struggle with delay dynamics that require precise measurement.
  • The proposed solution, Minimal Information State Markov Decision Process (MISMDP), introduces a minimal information set for real-time interactions and an approach called MRAC (Minimal information set for Real-time tasks using Actor-Critic), which shows improved performance in managing delays compared to existing algorithms, backed by solid theoretical analysis and extensive experimental results.
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  • Pediatric T-cell acute lymphoblastic leukemia (T-ALL) still poses significant challenges, including treatment resistance and recurrence, despite advances in prognosis, with LIM domain-binding protein 1 (LDB1) playing a crucial role in this context.
  • * Researchers utilized techniques like shRNA, RNA-Seq, and CUT&Tag to analyze LDB1's function in T-ALL cell lines and uncovered its cooperation with key transcription factors (ERG, ETV6, IRF1) to regulate downstream targets.
  • * The study concludes that LDB1 is essential for T-ALL cell proliferation and survival, specifically regulating the significant target gene MYB, thus providing insights into its role in T-ALL progression.*
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  • AML shows diverse clinical outcomes, with those originating from hematopoietic stem cells (HSCs) being more resistant to chemotherapy.
  • Research reveals that AML from HSCs contains more leukemic stem cells (LSCs) compared to AML from progenitor cells.
  • Epigenetic profiling suggests that inherited programs from normal HSCs contribute to the aggressive nature of HSC-AML, with RNA polymerase II-mediated transcription posing a potential therapeutic target.
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  • * Findings revealed varying concentrations of PAHs and OCPs, with higher PAHs linked to urbanization in the north and elevated OCPs due to historical agriculture in the south.
  • * Overall, Quanzhou Bay was identified as a low to medium ecological risk area, emphasizing the need for informed sustainable development and policy strategies based on human impact on contaminant distribution.
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The effects of co-exposure to antibiotics and microplastics in agricultural systems are still unclear. This study investigated the effects of florfenicol (FF) and polystyrene microplastics (PS-MPs) on photosynthetic carbon assimilation in rice seedlings. Both FF and PS-MPs inhibited photosynthesis, while PS-MPs can alleviate the toxicity of FF.

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The increasing use of antibiotics has attracted widespread attention to their environmental risks. However, the phototoxicity of sulfonamide antibiotics to plants remain unclear. In this study, the mechanism of the effect of sulfamethoxazole on photosynthesis of pakchoi cabbage (Brassica rapa var.

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Article Synopsis
  • Biochar-supported zerovalent iron (ZVI) composites show promise for removing nitrobenzene from contaminated groundwater and soil, but their impact on microbial communities has not been fully studied.
  • The study found that the 700°C biochar composite significantly improved nitrobenzene removal (up to 64.4%) and enhanced microbial diversity, while the 300°C composite had a negative effect on removal.
  • Overall, 700°C modified biochar composites increase microbial richness, support important functional genes, and promote electron transfer, making them effective for soil remediation of nitrobenzene contamination.
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Background: Despite the use of targeted therapeutic approaches, T-cell acute lymphoblastic leukemia (T-ALL) is still associated with a high incidence of complications and a poor prognosis. Indisulam (also known as E7070), a newly identified molecular glue compound, has demonstrated increased therapeutic efficacy in several types of cancer through the rapid degradation of RBM39. This study aimed to evaluate the therapeutic potential of indisulam in T-ALL, elucidate its underlying mechanisms and explore the role of the RBM39 gene.

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Purpose: To construct optimal models for predicting the invasiveness and pathological subtypes of subsolid nodules (SSNs) based on CT radiomics and clinical features.

Materials And Methods: This study was a retrospective study involving two centers. A total of 316 patients with 353 SSNs confirmed as atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) were included from January 2019 to February 2023.

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Synopsis of recent research by authors named "Zhiheng Li"

  • - Zhiheng Li's recent research covers a diverse range of topics, including electrochemical energy systems, acute myeloid leukemia treatments, and novel reinforcement learning methods, reflecting a multidisciplinary approach to scientific inquiry.
  • - A significant finding in his work on perovskite catalysts indicates that machine learning can effectively predict oxygen vacancy concentrations, impacting catalytic activity and efficiency across various temperature conditions.
  • - In the field of cancer research, Li's studies identify new therapeutic targets in acute myeloid leukemia, specifically focusing on PDE3A, and explore the mechanisms behind leukemogenesis, highlighting the role of the hematopoietic cell of origin in treatment resistance.

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