Efficiency Boost in Through Space Charge Transfer Emitters: Insights from Spiro Lateral Rocking Confinement.

Intramolecular through-space charge-transfer (TSCT) excited states have emerged as promising candidates for thermally activated delayed fluorescence (TADF) emitters. This study addresses the challenges in tuning excited state dynamics through conformational engineering, which significantly impacts exciton utilization. An effective strategy is presented to enhance the performance of TSCT-TADF molecules by restricting the lateral rocking of the spiro unit via immobilizing groups, which indirectly adjusts the conformations of the donor and acceptor subunits.

Dietary nucleotides drive changes in infant fecal microbiota in vitro and gut microbiota-gut-brain development in neonatal rats: A potential "nitrogen source" for early microbiota growth.

Various dietary factors in human milk are important nutrients for the formation of the infant gut microbiota (GM). While promoting the growth of the GM, some human milk components that are difficult to absorb and utilize will be broken down by the GM, and converted into nutrients that the baby can use, such as breast milk oligosaccharides-the 'carbon source' for infant GM. This study reveals that nucleotides (NTs), significant non-protein nitrogen sources in human milk, can enhance the abundance of beneficial microbial genera such as g_Bifidobacterium, g_Bacteroides, and g_Blautia in in vitro fecal fermentation fluids of infants at low doses (2 mg/mL).

Bis-tridentate Ir(III) Phosphors and Blue Hyperphosphorescence with Suppressed Efficiency Roll-Off at High Brightness.

Narrowband blue emitters are indispensable in achieving ultrahigh-definition OLED displays that satisfy the stringent BT 2020 standard. Hereby, a series of bis-tridentate Ir(III) complexes bearing electron-deficient imidazo[4,5-]pyridin-2-ylidene carbene coordination fragments and 2,6-diaryloxy pyridine ancillary groups were designed and synthesized. They exhibited deep blue emission with quantum yields of up to 89% and a radiative lifetime of 0.

Dietary Nucleotides Promote Neonatal Rat Microbiota-Gut-Brain Axis Development by Affecting Gut Microbiota Composition and Metabolic Function.

A variety of active factors in milk and foods have been proven to serve as microbial nutrients that regulate the formation of early gut microbiota (GM), thereby ensuring the healthy development of infants. This study demonstrated that dietary nucleotides (NTs), one of the main nitrogen-containing substances in human milk, promoted the neurodevelopment of neonatal rats and the expression of Sox2, Dcx, Tuj1, and NeuN in the prefrontal cortex and hippocampus, but had no significant regulatory effects in the striatum. 16s rRNA sequencing and metabolomics of the colon contents of neonatal rats at different developmental stages showed that the early intake of NTs promoted an increase in the abundance of beneficial microorganisms related to neurodevelopment, digestion, and gut absorption, such as and Changes in the ability of the GM to regulate folate synthesis, riboflavin metabolism, and other processes were also observed.

Topologically enhanced nonlinear optical response of graphene nanoribbon heterojunctions.

We study the nonlinear optical properties of heterojunctions made of graphene nanoribbons (GNRs) consisting of two segments with either the same or different topological properties. By utilizing a quantum mechanical approach that incorporates distant-neighbor interactions, we demonstrate that the presence of topological interface states significantly enhances the second- and third-order nonlinear optical response of GNR heterojunctions that are created by merging two topologically inequivalent GNRs. Specifically, GNR heterojunctions with topological interface states display third-order harmonic hyperpolarizabilities that are more than two orders of magnitude larger than those of their similarly sized counterparts without topological interface states, whereas the second-order harmonic hyperpolarizabilities exhibit a more than ten-fold contrast between heterojunctions with and without topological interface states.

Network Coding Approaches for Distributed Computation over Lossy Wireless Networks.

In wireless distributed computing systems, worker nodes connect to a master node wirelessly and perform large-scale computational tasks that are parallelized across them. However, the common phenomenon of straggling (i.e.

Effect of germination pretreatment on the physicochemical properties and lipid concomitants of flaxseed oil.

This study investigated the effects of germination pretreatment on the physicochemical properties, lipid concomitants, and antioxidant activity of flaxseed oil in three varieties. The results indicated that the oil content of flaxseed decreased by 2.29-7.

Robust Laminated Anode with an Ultrathin Titanium Nitride Layer for High-Efficiency Top-Emitting Organic Light-Emitting Diodes.

The effective reflective anode remains a highly desirable component for the fabrication of reliable top-emitting organic light-emitting diodes (TE-OLEDs) which have the potential to be integrated with complementary metal-oxide-semiconductor (CMOS) circuits for microdisplays. This work demonstrates a novel laminated anode consisting of a Cr/Al/Cr multilayer stack. Furthermore, we implement an ultra-thin titanium nitride (TiN) layer as a protective layer on the top of the Cr/Al/Cr composite anode, which creates a considerably reflective surface in the visible range, and meanwhile improves the chemical stability of the electrode against the atmosphere or alkali environment.

Fecal microbiota transplantation for diseases: Therapeutic potential, methodology, risk management in clinical practice.

Background: More than 95 % of human diseases may be related to the disturbance of gut microbes. As a treatment method that extensively regulates the gut microbes, fecal microbiota transplantation (FMT) has proven to be an effective therapy for some diseases, becoming a topic of interest among clinicians, patients and scientists.

Aim: To review the latest clinical research results of FMT in the treatment of various diseases and the methodology and risk management in clinical application.

Identification and Functional Characterization of Metabolites for Skeletal Muscle Mass in Early Postmenopausal Chinese Women.

Low skeletal muscle mass (SMM) is a crucial component of the sarcopenia phenotypes. In the present study, we aim to identify the specific metabolites associated with SMM variation and their functional mechanisms of decreased SMM in early postmenopausal women. We performed an untargeted metabolomics analysis in 430 early postmenopausal women to identify specific metabolite associated with skeletal muscle mass indexes (SMIes).

The Regulatory effect of chlorogenic acid on gut-brain function and its mechanism: A systematic review.

Chlorogenic acid (CGA) is a phenolic compound that is widely distributed in honeysuckle, Eucommia, fruits and vegetables. It has various biological functions, including cardiovascular, nerve, kidney, and liver protection, and it exerts a protective effect on human health, according to clinical research and basic research. The intestine and brain are two important organs that are closely related in the human body.

Mechanism, indexes, methods, challenges, and perspectives of edible oil oxidation analysis.

Edible oils are indispensable food components, because they are used for cooking or frying. However, during processing, transport, storage, and consumption, edible oils are susceptible to oxidation, during which various primary and secondary oxidative products are generated. These products may reduce the nutritional value and safety of edible oils and even harm human health.

Theaflavin Promotes Mitochondrial Abundance and Glucose Absorption in Myotubes by Activating the CaMKK2-AMPK Signal Axis via Calcium-Ion Influx.

Drinking tea has been proven to have a positive biological effect in regulating human glucose and lipid metabolism and preventing type 2 diabetes (T2D). Skeletal muscle (SkM) is responsible for 70% of the sugar metabolism in the human body, and its dysfunction is an important factor leading to the development of obesity, T2D, and muscle diseases. As one of the four known theaflavins (TFs) in black tea, the biological role of theaflavin (TF1) in regulating SkM metabolism has not been reported.

Natural products and skeletal muscle health.

Skeletal muscle (SkM) is essential for body movement, energy metabolism, and material metabolism, and directly influences the quality of human life. Aging, chronic diseases, and strenuous exercise often lead to various health problems associated with SkM, including muscle atrophy, loss of muscle mass and strength, and metabolic disorders. Various natural products (NaPs), mainly resveratrol (RES), quercetin (QUE), ursolic acid (UA), ecdysone (ECD; mainly 20-OH ECD, 20-HE), and vitamin D, have been reported to protect or regulate SkM health.

Theaflavin Promotes Myogenic Differentiation by Regulating the Cell Cycle and Surface Mechanical Properties of C2C12 Cells.

Aging and muscle diseases often lead to a decline in the differentiation capacity of myoblasts, which in turn results in the deterioration of skeletal muscle (SkM) function and impairment of regeneration ability after injury. Theaflavins, the "gold molecules" found in black tea, have been reported to possess various biological activities and have a positive effect on maintaining human health. In this study, we found that among the four theaflavins (theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3'-gallate (TF2B), and theaflavin-3,3'-digallate (TF3) monomers), TF1 (20 μM) significantly promoted the fusion index of myoblasts, number of mature myotubes, and degree of myotube development.

Advances in physiological functions and mechanisms of (-)-epicatechin.

(-)-Epicatechin (EC) is a flavanol easily obtained through the diet and is present in tea, cocoa, vegetables, fruits, and cereals. Recent studies have shown that EC protects human health and exhibits prominent anti-oxidant and anti-inflammatory activities, enhances muscle performance, improves symptoms of cardiovascular and cerebrovascular diseases, prevents diabetes, and protects the nervous system. With the development of modern medical and biotechnology research, the mechanisms of action associated with EC toward various chronic diseases are becoming more apparent, and the pharmacological development and utilization of EC has been increasingly clarified.

Role and mechanism of catechin in skeletal muscle cell differentiation.

Muscle degeneration and cachexia caused by aging and chronic diseases seriously reduce the quality of life of patients. Catechins in tea enhance skeletal muscle performance, but the specific function and mechanism require further exploration. Myogenic differentiation is accompanied by extensive changes in cell morphology and gene expression patterns.

Advances in the Antagonism of Epigallocatechin-3-gallate in the Treatment of Digestive Tract Tumors.

Due to changes in the dietary structure of individuals, the incidence of digestive tract tumors has increased significantly in recent years, causing a serious threat to the life and health of patients. This has in turn led to an increase in cancer prevention research. Many studies have shown that epigallocatechin-3-gallate (EGCG), an active ingredient in green tea, is in direct contact with the digestive tract upon ingestion, which allows it to elicit a significant antagonizing effect on digestive tract tumors.

sp. nov., isolated from arctic glacial foreland soil.

A novel psychrotolerant bacterium, designed strain M6-79, was isolated from an arctic glacial foreland soil sample collected from Ny-Ålesund in the Svalbard Archipelago, Norway. Cells of strain M6-79 were Gram-stain-negative, rod-shaped and produced a red-pigment. Strain M6-79 was strictly aerobic, non-motile, non-endospore-forming, oxidase-negative and catalase-positive.

Pseudorhodobacter collinsensis sp. nov., isolated from a till sample of an icecap front.

A Gram-stain-negative, rod-shaped, aerobic and non-motile strain, designated 4-T-34T, was isolated from a till sample of Collins icecap front, Antarctica, and its taxonomic position was investigated by genotypic, phenotypic and chemotaxonomic analysis. The isolate grew at 4-30 °C (optimum 20-25 °C), at pH 6.0-10.

Flavobacterium collinsense sp. nov., isolated from a till sample of an Antarctic glacier.

A novel rod-shaped, Gram-stain-negative, non-gliding and aerobic strain surrounded by a multilayer capsule, designated 4-T-2T, was isolated from a till sample of Collins glacier front, Antarctica. The bacterium formed yellow, circular, convex and smooth colonies. Growth occurred at 4-28 °C (optimum18-20 °C), at pH 7.

Nocardioides antarcticus sp. nov., isolated from marine sediment.

Strain M-SA3-94T, an aerobic, Gram-stain-positive, ovoid- to rod-shaped, non-motile bacterium, was isolated from the marine sediment of Ardley cove, King George Island, Antarctica. Strain M-SA3-94T grew optimally at pH 5.0-6.

Roseovarius antarcticus sp. nov., isolated from a decayed whale bone.

A pale yellow, ovoid- to rod-shaped and budding bacterium, designated strain M-S13-148(T), was isolated from a decayed bone of whale from the eastern coast of King George Island, South Shetlands, Antarctica. Strain M-S13-148(T) exhibited motility, aerobic growth and was Gram-stain-negative. Strain M-S13-148(T) was positive for catalase and oxidase.

Parablastomonas arctica gen. nov., sp. nov., isolated from high Arctic glacial till.

A pale yellow, aerobic bacterium, strain M0-2(T), was isolated from a till sample. Its taxonomic position was investigated by using a polyphasic approach. Cells were Gram-stain-negative, rod-shaped and motile.