Transition-Metal-Doped Nickel-Cobalt Layered Double Hydroxide Catalysts for an Efficient Oxygen Evolution Reaction.

Hydrogen plays a vital role in the global shift toward cleaner energy solutions, with water electrolysis standing out as one of the most promising techniques for generating hydrogen. Despite its potential, the oxygen evolution reaction (OER) involved in this process faces significant challenges, including high overpotentials and slow reaction rates, which underscore the need for advanced electrocatalytic materials to enhance efficiency. Noble metal catalysts are effective but expensive, so transition-metal-based electrocatalysts like nickel-cobalt layered double hydroxides (NiCo LDHs) have become promising alternatives.

NF-κB inhibitor PDTC involved in regulating the transplantation immunity in the pearl oyster Pinctada fucata martensii.

Nuclear factor kappa B (NF-κB) is involved in various important biological processes, such as inflammation, apoptosis, and cell proliferation. Here, we analyzed the function of NF-κB in transplantation immunity and pearl formation using its inhibitor, pyrrolidinedithiocarbamic acid (PDTC), in the pearl oyster Pinctada fucata martensii. The levels of pro-inflammatory factors (IL-17 and TNF-α) were lower and activity of antioxidant-related enzymes was higher in the transplanted pearl oysters pre-treated with PDTC than in transplanted pearl oysters pre-treated with phosphate-buffered saline (PBS).

Transcutaneous electrical acupoint stimulation for hypertension complicated by anxiety or sleep disorders: A pilot randomized controlled trial.

Background: Hypertension is often accompanied by anxiety and sleep disorders, which further complicate the disease. This study aimed to evaluate the feasibility and effectiveness of transcutaneous electrical acupoint stimulation (TEAS) in patients with hypertension and anxiety or sleep disorders.

Methods: Eligible participants were randomly assigned to the 10 Hz TEAS, 2 Hz TEAS, or routine treatment groups in a 1:1:1 ratio.

Research on a Service Touchpoint Design Model Driven by Smart Technology Based on Kano-Failure Modes and Effects Analysis.

With the development of smart technology and the increasing variety of everyday products, factors influencing product service touchpoint design have become more diverse and complex. Existing service touchpoint design methods and models often focus narrowly on user research, co-design, and risk analyses, lacking a systematic approach. Consequently, they struggle to deliver solutions that align with user needs.

Whole-genome sequencing identified candidate genes associated with high and low litter size in Chuanzhong black goats.

The reproductive performance of goats significantly influences breeding efficiency and economic returns, with litter size serving as a comprehensive indicator. Despite this, research on the genetic control of litter size remains limited. Therefore, we aimed to explore the candidate genes affecting fecundity and compared the whole-genome sequences (WGS) of 15 high-litter (HL) and 15 low-litter (LL) size in Chuanzhong black goats.

Kilogram-scale production of strong and smart cellulosic fibers featuring unidirectional fibril alignment.

Multifunctional fibers with high mechanical strength enable advanced applications of smart textiles, robotics, and biomedicine. Herein, we reported a one-step degumming method to fabricate strong, stiff, and humidity-responsive smart cellulosic fibers from abundant natural grass. The facile process involves partially removing lignin and hemicellulose functioning as glue in grass, which leads to the separation of vessels, parenchymal cells, and cellulosic fibers, where cellulosic fibers are manufactured at kilogram scale.

SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress.

Infiltration of monocyte-derived macrophages plays a crucial role in cardiac remodeling and dysfunction. The serum and glucocorticoid-inducible protein kinase 3 (SGK3) is a downstream factor of PI3K signaling, regulating various biological processes via an AKT-independent signaling pathway. SGK3 has been implicated in cardiac remodeling.

KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis.

In this study, we aimed to investigate the molecular mechanism of Krüppel-like factor 7 (KLF7) in colorectal cancer (CRC) cell invasion and migration. The expression pattern of KLF7 in CRC tissues and the correlation between KLF7 expression and clinical symptoms of CRC were analyzed. CRC cell lines were transfected with si-KLF7, followed by qRT-PCR or western blot detection of KLF7, miR-139-5p, and tumor protein D52 (TPD52) expression, cell counting kit-8 (CCK-8) assay to detect cell viability, and transwell detection of invasion and migration.

Interferon subverts an AHR-JUN axis to promote CXCL13 T cells in lupus.

Systemic lupus erythematosus (SLE) is prototypical autoimmune disease driven by pathological T cell-B cell interactions. Expansion of T follicular helper (T) and T peripheral helper (T) cells, two T cell populations that provide help to B cells, is a prominent feature of SLE. Human T and T cells characteristically produce high levels of the B cell chemoattractant CXCL13 (refs.

Effect of Calcination Atmosphere on the Performance of Cu/AlO Catalyst for the Selective Hydrogenation of Furfural to Furfuryl Alcohol.

The selective hydrogenation of the biomass platform molecule furfural (FAL) to produce furfuryl alcohol (FA) is of great significance to alleviate the energy crisis. Cu-based catalysts are the most commonly used catalysts, and their catalytic performance can be optimized by changing the preparation method. This paper emphasized the effect of calcination atmosphere on the performance of a Cu/AlO catalyst for the selective hydrogenation of FAL.

Ribosomal Dysregulation in Metastatic Laryngeal Squamous Cell Carcinoma: Proteomic Insights and CX-5461's Therapeutic Promise.

One of the main barriers to the successful treatment of laryngeal squamous cell carcinoma (LSCC) is postoperative progression, primarily due to tumor cell metastasis. To systematically investigate the molecular characteristics and potential mechanisms underlying the metastasis in laryngeal cancer, we carried out a TMT-based proteomic analysis of both cancerous and adjacent non-cancerous tissues from 10 LSCC patients with lymph node metastasis (LNM) and 10 without. A total of 5545 proteins were quantified across all samples.

Construction of Nanofibrillar Networked Wood Aerogels Derived from Typical Softwood and Hardwood: A Comparative Study on the In Situ Formation Mechanism of Nanofibrillar Networks.

The construction of networks within natural wood (NW) lumens to produce porous wood aerogels (WAs) with fascinating characteristics of being lightweight, flexible, and porous is significant for the high value-added utilization of wood. Nonetheless, how wood species affect the structure and properties of WAs has not been comprehensively investigated. Herein, typical softwood of fir and hardwoods of poplar and balsa are employed to fabricate WAs with abundant nanofibrillar networks using the method of lignin removal and nanofibril's in situ regeneration.

Mobile phone problem use and depressive symptoms: the mediating role of social support and attitude to aging among Chinese older adults.

Background: Little is known about mobile phone problem use (MPPU) among older adults. This study investigated critical factors affecting MPPU and filled the gap between MPPU and depressive symptoms in older people.

Methods: A cross-sectional study was conducted in community (n = 376) with questionnaires of Multidimensional Scale of Perceived Social Support (MSPSS), Geriatric Depression Scale (GDS-15), Attitudes to Aging Questionnaire (AAQ) and Mobile Phone Problem Use Scale (MPPUS).

A nanobody inhibiting porcine reproductive and respiratory syndrome virus replication via blocking self-interaction of viral nucleocapsid protein.

Porcine reproductive and respiratory syndrome (PRRS) is a serious global pig industry disease. Understanding the mechanism of viral replication and developing efficient antiviral strategies are necessary for combating with PRRS virus (PRRSV) infection. Recently, nanobody is considered to be a promising antiviral drug, especially for respiratory viruses.

Hydrodynamics of Butterfly-Mode Flapping Propulsion of Dolphin Pectoral Fins with Elliptical Trajectories.

This article aims to numerically study the hydrodynamic performance of the bionic dolphin equipped with a pair of rigid pectoral fins. We use dynamic-grid technology and user-defined functions to simulate a novel butterfly-mode flapping propulsion of the fins. This pattern of propulsion is composed of three angular degrees of freedom including the pitch angle , the azimuth angle and the roll angle , which can be divided into four stages for analysis within a single cycle.

Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle.

Here, we present a case with genetically confirmed SCN. The main symptom of the child was recurring fever. The combination of antibiotics combined with G-CSF injection was proved to be insufficient, and the patient developed "solid" liver abscess.

Exploring associations between social media addiction, social media fatigue, fear of missing out and sleep quality among university students: A cross-section study.

Background: Social media use has been linked to poor sleep outcomes among university students in the cyber age, but the association between the negative consequences of social media use and sleep problems is not yet well understood. The present study investigated the relationships among social media usage, social media fatigue (SMF), fear of missing out (FoMO), social media addiction (SMA) and sleep quality in university students.

Method: An online survey was administered to 2744 respondents that included the Pittsburgh Sleep Quality Index (PSQI); questionnaires evaluating FoMO, SMF, and SMA; and questions regarding sleep duration, social media use, health status, and demographic information.

Development of a Variable-Configuration Bionic Robotic Fish.

Bionic robotic fish have advantages over traditional underwater propulsion. Most of the existing studies have been conducted with only one type of fish as a bionic object, but a single propulsion mode may not be able to achieve the different needs of underwater operations. In this paper, we designed a pneumatic variable-configuration soft bionic fish and completed the overall structure design.

Temperature and strain simultaneous sensing measurement based on an all-fiber Mach-Zehnder interferometer and fiber Bragg grating.

We designed and fabricated what we believe to be a novel dual-parameter fiber optic sensor for simultaneous measurement of temperature and strain, which was composed of a femtosecond laser inscribed fiber Bragg grating (FBG), three segments of a single-mode fiber (SMF), and two segments of a multimode fiber (MMF), forming a SMF-MMF-FBG-MMF-SMF structure. The FBG and Mach-Zehnder interferometer (MZI) were present in this structure so that the changes of the temperature and strain parameters can be sensed by the shifts of the reflection center wavelength of the FBG and the interference valley wavelength of the MZI. We simulated the light field distribution of the sensor structure, compared the shapes of the interference spectra formed by the MZI structure with different sensing arm lengths of 25, 35, and 45 mm, and analyzed the spectra in the spatial frequency domain.

Lignin Adhesion for High-Performance Bamboo Composites.

Bamboo composite is an attractive candidate for structural materials in applications such as construction, the automotive industry, and logistics. However, its development has been hindered due to the use of harmful petroleum-derived synthetic adhesives or low-bonding biobased adhesives. Herein, we report a novel bioadhesion strategy based on lignin bonding that can process natural bamboo into a scalable and high-performance composite.

Pure cellulose nanofiber separator with high ionic conductivity and cycling stability for lithium-ion batteries.

Conventional polyolefin separators are constrained by poor electrolyte wettability, inferior thermal stability, and low ionic conductivity, which seriously restrict their application in high-performance lithium-ion batteries (LIBs). Herein, cellulose nanofiber (CNF) as the matrix and tert-butyl alcohol (TBA) as the dispersion medium were used to prepare the pure CNF separators for LIBs by a facile filtration method. The effects of the drying temperature on the pore structure, electrolyte wettability, mechanical properties, thermal stability, and ionic conductivity of the separators were comprehensively investigated.

A Comparative and Collaborative Study of the Hydrodynamics of Two Swimming Modes Applicable to Dolphins.

This paper presents a hydrodynamics study that examines the comparison and collaboration of two swimming modes relevant to the universality of dolphins. This study utilizes a three-dimensional virtual swimmer model resembling a dolphin, which comprises a body and/or caudal fin (BCF) module, as well as a medium and/or paired fin (MPF) module, each equipped with predetermined kinematics. The manipulation of the dolphin to simulate various swimming modes is achieved through the application of overlapping grids in conjunction with the parallel hole cutting technique.

A Prospective and Randomized Control Study on Effects of Thymalfasin for Injection on Perioperative Immune Function and Long-term Prognosis of Patients with Colorectal Cancer.

The objective of this study is to explore the effects of thymalfasin for injection on perioperative immune function and long-term prognosis of patients with colorectal cancer (CRC). In total, 400 patients who entered the groups from February 2019 to January 2021 and underwent radical resection of CRC in the Fourth Hospital of Hebei Medical University were the study subjects. They were separated into experimental group (0-199, XELOX chemotherapy and thymalfasin for injection) and control group (200-400, XELOX chemotherapy) by random number table, and the experimental group was randomly divided into conventional-dose group ( = 100, 1.