Publications by authors named "Zhihan Claire Wang"
Article Synopsis
- * The study focused on how CVB3 interacts with macrophage cells, revealing that it activates these immune cells without replicating inside them and that macrophages lack the viral entry receptor needed for infection.
- * Additionally, introducing the receptor in macrophages did not enable viral replication but changed inflammatory responses; the research also identified the autophagy protein LC3 as a key player in activating macrophages.
Coxsackievirus B3 (CVB3) is a non-enveloped, single-stranded, positive RNA virus known for its role in provoking inflammatory diseases that affect the heart, pancreas, and brain, leading to conditions such as myocarditis, pancreatitis, and meningitis. Currently, there are no FDA-approved drugs treating CVB3 infection; therefore, identifying potential molecular targets for antiviral drug development is imperative. In this study, we examined the possibility of activating the cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway, a cytosolic DNA-sensing pathway that triggers a type-I interferon (IFN) response, in inhibiting CVB3 infection.
View Article and Find Full Text PDF