Publications by authors named "Zhihai Qu"
Insufficient trophoblast cell infiltration is implicated in the progression of preeclampsia (PE). The immunoglobulin superfamily member 8 (IGSF8) has been shown to promote cell migration, invasion, and epithelial mesenchymal transition (EMT). However, the specific impact of IGSF8 on trophoblast cells in PE has not been definitively demonstrated.
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- - SORBS2 is an RNA-binding protein that regulates aerobic glycolysis, crucial for placenta development and trophoblast migration, essential processes for successful pregnancy.
- - In preeclampsia, reduced levels of SORBS2 impair trophoblast migration by affecting the stability of mRNA related to glycolysis, which may lead to complications in placentation.
- - The study reveals that SORBS2 enhances the stability of the glycolysis gene HK2, promoting cell migration and proliferation; silencing HK2 negates the positive effects of SORBS2, linking it to preeclampsia pathogenesis.