Publications by authors named "Zhiguo Wu"

Gold ores are important strategic key mineral resource in China. The Sanshan Island area produces gold ores, in which the magmatic activity becomes the heat source for the activation of gold-bearing fluids, and the widely developed fracture structure provides the channel and spatial structure for gold transport and enrichment. Therefore, it is an important direction to utilize the inversion method to portray the distribution of fractures and intrusive rocks.

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Cu in wastewater is hazardous to human health, and adsorption technology can effectively remove heavy metal ions. In this study, sulfhydryl graphene oxide/chitosan/ε-polylysine (SGCS-E) polymeric antimicrobial materials were prepared using 3D printing technology. These materials were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and XPS.

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Objective: It remains unclear whether low-molecular-weight heparin (LMWH) is effective and safe for intracerebral hemorrhage (ICH) patients. This study presents a meta-analysis for elucidating effect of LMWH on preventing venous thromboembolism (VTE) among ICH patients.

Methods: Articles were located by systematically searching PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), WANFANG DATA, VIP, and SinoMed databases.

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The genomes and annotated genes of allotetraploid cotton have been extensively studied in recent years. However, the expression, regulation, and evolution of intergenic genes (ITGs) have not been completely deciphered. In this study, we identified a novel set of actively expressed ITGs in cotton, through transcriptome profiling based on deep sequencing data, as well as chromatin immunoprecipitation, followed by sequencing (ChIP-seq) of histone modifications and how the ITGs evolved.

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Article Synopsis
  • Liuwei dihuang pills, a popular Traditional Chinese Medicine, contains D-glucaro-1,4-lactone (1,4-GL), which has shown anti-cancer properties, notably in inhibiting β-glucuronidase, but its exact mechanisms are not yet fully understood.
  • This study aims to investigate how 1,4-GL can delay the progression of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats, using various biochemical and molecular analysis methods.
  • Results showed that treatment with 1,4-GL improved liver health in HCC rats and significantly influenced purine metabolism, indicating its potential therapeutic benefits against cancer.
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Copper ions in wastewater pose a significant threat to human and ecological safety. Therefore, preparing macroscopic adsorbents with reusable and high adsorption performance is paramount. This paper used graphene oxide as the adsorbent and chitosan as the thickener.

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In this research, a new material, chitosan/polypyrrole (CS/PPy), was synthesized and linked with the Cr(VI)-reducing bacterial strain YL3 to treat Cr(VI)-polluted soil. The findings demonstrated that the synergistic application of strain YL3 and CS/PPy achieved the greatest reduction (99.6 %).

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Ammonia nitrogen (NH-N/NH-N) serves as a crucial chemical in biochemistry and fertilizer synthesis. However, it is also a toxic compound, posing risks from eutrophication to direct threats to human health. Ammonia nitrogen pollution pervades water sources, presenting a significant challenge.

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Background: Enteric glia are essential components of the enteric nervous system. Previously believed to have a passive structural function, mounting evidence now suggests that these cells are indispensable for maintaining gastrointestinal homeostasis and exert pivotal influences on both wellbeing and pathological conditions. This study aimed to investigate the global status, research hotspots, and future directions of enteric glia.

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Article Synopsis
  • - The study focuses on developing BCMA/CD47-directed universal CAR-T cells (UCAR-T cells) to enhance treatment for relapsed/refractory multiple myeloma (RRMM), addressing issues with the existing CAR-T preparation process which is complicated and expensive.
  • - Researchers used phage display technology to identify specific nanobodies targeting BCMA and CD47, and applied CRISPR/Cas9 to create T cells that do not express TCR and HLA, leading to the formation of BCMA/CD47-directed UCAR-T cells with high CAR expression.
  • - The UCAR-T cells demonstrated strong antitumor effects in laboratory and animal models, suggesting a promising new approach for developing more accessible cellular immunotherapies for
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Background: The effect of first-line complex decongestive therapy (CDT) for breast cancer-related lymphedema (BCRL) depending on various factors forces patients to seek additional treatment. Therefore, this meta-analysis was conducted to evaluate the effect of different conservative medical interventions as a complement to CDT. This is the first meta-analysis that includes various kinds of conservative treatments as adjunctive therapy to get broader knowledge and improve practical application value, which can provide recommendations to further improve BCRL patients' health status.

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The microdomains of plasmodesmata, specialized cell-wall channels responsible for communications between neighboring cells, are composed of various plasmodesmata-located proteins (PDLPs) and lipids. Here, we found that, among all PDLP or homologous proteins in Arabidopsis thaliana genome, PDLP5 and PDLP7 possessed a C-terminal sphingolipid-binding motif, with the latter being the only member that was significantly upregulated upon turnip mosaic virus and cucumber mosaic virus infections. pdlp7 mutant plants exhibited significantly reduced callose deposition, larger plasmodesmata diameters, and faster viral transmission.

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Background: To explore the demographic and clinical features of current depressive episode that discriminate patients diagnosed with major depressive disorder (MDD) from those with bipolar I (BP-I) and bipolar II (BP-II) disorder who were misdiagnosed as having MDD .

Methods: The Mini-International Neuropsychiatric Interview (MINI) assessment was performed to establish DSM-IV diagnoses of MDD, and BP-I and BP-II, previously being misdiagnosed as MDD. Demographics, depressive symptoms and psychiatric comorbidities were compared between 1463 patients with BP-I, BP-II and MDD from 8 psychiatric settings in mainland China.

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Investigation of the pharmacokinetics of sorafenib (SRF) in rats with hepatocellular carcinoma (HCC). A reproducible ultra-HPLC-MS method for simultaneous determination of serum SRF, -hydroxymethyl sorafenib and -demethylation sorafenib. Both the maximum serum concentrations (2.

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Background: This research was designed to investigate Algorithm Guided Treatment (AGT) and clinical traits for the prediction of antidepressant treatment outcomes in Chinese patients with major depressive disorder (MDD).

Methods: This study included 581 patients who had reached treatment response and 406 patients remained non-responded observed after three months of treatment. Sociodemographic factors, clinical traits, and psychiatric rating scales for evaluating therapeutic responses between the two groups were compared.

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Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a rare and severe form of end-stage liver disease with high mortality; gut microbes are strongly associated with the development of this severe liver disease but the exact association is unclear. Artificial liver support systems (ALSS) are clinically important in prolonging the waiting time for liver transplantation and in aiding drug therapy to achieve remission. The aim of this study was to investigate the effect of ALSS on the abundance and diversity of microorganisms in the gut of HBV-ACLF patients.

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The aim of this study was to compare the pharmacokinetics and steady-state serum concentrations of lenvatinib in adult and juvenile rats. An ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method was developed to quantify lenvatinib in the serum and liver of rats. Six juvenile and six adult rats in each group were orally administered with a single dose of 7.

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Background: Artificial liver support systems (ALSSs) are important approaches for treating acute-on-chronic liver failure (ACLF) patients. Few studies have investigated potential serum therapeutic markers of ACLF patients treated by ALSSs.

Methods: Serum samples were obtained from 57 early to middle stage ACLF patients before and after ALSSs treatment and analyzed by metabonomics.

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Aspirin decreases liver fibrosis index and inflammation levels. However, the exact mechanism underlying the effects of aspirin are yet to be elucidated. The aim of the study was to investigate the potential protective effects of aspirin on carbon tetrachloride (CCl)-induced hepatic fibrosis in Sprague-Dawley rats.

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Objective: To explore clinical characteristics and symptomatology of major depressive disorder (MDD) with atypical features based on DSM criteria or only reversed vegetative symptoms.

Method: A total of 3187 patients who met DSM-IV TR criteria for MDD were enrolled. Demographics and symptomatology covering multiple symptom domains were assessed and compared between three groups of cases: those who met DSM criteria for atypical specifier (the DAD group), those who had at least one reversed vegetative symptoms (hypersomnia or hyperphagia) (the SAD group) without meeting DSM atypical specifier criteria, and those without any reversed vegetative symptoms (the NAD group).

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