Excitation-Dependent Anti-Thermal Quenching in Zero-Dimensional Manganese Bromides for Photoluminescence and X-Ray Scintillation.

One of the most significant challenges of luminescent materials is the thermal quenching (TQ) at high temperature. Understanding the correlation between crystal structure variation and photoluminescence (PL) quenching is significant to achieve anti-thermal quenching (anti-TQ) phosphors. Herein, we unveil a universal principle governing switchable TQ and anti-TQ behaviors in zero-dimensional (0D) organic-inorganic hybrid manganese bromides.

Deep learning-based automated scan plane positioning for brain magnetic resonance imaging.

Background: Manual planning of scans in clinical magnetic resonance imaging (MRI) exhibits poor accuracy, lacks consistency, and is time-consuming. Meanwhile, classical automated scan plane positioning methods that rely on certain assumptions are not accurate or stable enough, and are computationally inefficient for practical application scenarios. This study aims to develop and evaluate an effective, reliable, and accurate deep learning-based framework that incorporates prior physical knowledge for automatic head scan plane positioning in MRI.

A combined nanotherapeutic approach targeting farnesoid X receptor, ferroptosis, and fibrosis for nonalcoholic steatohepatitis treatment.

Obeticholic acid (OCA), a farnesoid X receptor (FXR) agonist with favorable effects on fatty and glucose metabolism, has been considered the leading candidate drug for nonalcoholic steatohepatitis (NASH) treatment. However, its limited effectiveness in resolving liver fibrosis and lipotoxicity-induced cell death remains a major drawback. Ferroptosis, a newly recognized form of cell death characterized by uncontrolled lipid peroxidation, is involved in the progression of NASH.

Preparation of Amphiphilic Janus-SiO Nanoparticles and Evaluation of the Oil Displacement Effect.

In order to meet the requirements of tertiary oil recovery technology in a low-permeability, dense, and high-salt reservoir, gaseous SiO nanoparticles were modified with trichloro(octyl)silane and aminopropyl triethoxysilane by interface protection modification, and amphiphilic Janus-SiO nanoparticles with hydrophobic carbon chain and hydrophilic amino group were prepared. The basic properties of amphiphilic nanoparticle dispersion were evaluated by surface interfacial tension and wettability tests, and the oil displacement effect of amphiphilic nanoparticle dispersion was investigated. The results show that the size distribution of Janus-SiO nanoparticles with n-octyl as the hydrophobic carbon chain and amino group as the hydrophilic headgroup is uniform, and they have good dispersion in mineralized water.

Knockdown of BACE1 by a multistage brain-targeting polyion complex improved memory and learning behaviors in APP/PS1 transgenic mouse model.

Cleavage of Amyloid precursor protein (APP) by the β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting step in the production of amyloid-β (Aβ) synaptotoxins. The siRNA-mediated silencing to attenuate the expression of BACE1 to ameliorate cognitive dysfunction in mice had been investigated. To improve therapeutic gene delivery to the central nervous system, cationic copolymer poly(ethylene glycol)-b-poly[N-(N'-{N''-[N'''-(2-aminoethyl)-2-aminoethyl]-2-aminoethyl}-2-aminoethyl)aspartamide]-cholesterol was synthesized, then RVG29 and Tet1 peptides were exploited as ligands to construct a dual-targeting brain gene delivery polyion complex (Tet1/RVG29-PIC).

Neuronal-type-specific epigenome editing to decrease expression: Implications for precision medicine in synucleinopathies.

Overexpression of has been implicated in the pathogenesis of synucleinopathies, particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB). While PD and DLB share some clinical and pathological similarities, each disease presents distinct characteristics, including the primary affected brain region and neuronal type. We aimed to develop neuronal-type-specific -targeted epigenome therapies for synucleinopathies.

Recurrence of scalp angiosarcoma after multiple surgeries: A case report and literature review.

Scalp angiosarcoma (SA) is rare, accounting for <1% of soft tissue sarcomas, with a high degree of malignancy, a high recurrence rate and a poor prognosis. The best treatment strategy is uncertain. Therefore, it is essential to continuously refine treatment strategies and improve the prognosis of patients.

Ferroptosis: potential targets and emerging roles in pancreatic diseases.

Ferroptosis is a newly discovered form of regulatory cell death characterized by excessive iron-dependent lipid peroxidation. In the past decade, significant breakthroughs have been made in comprehending the features and regulatory mechanisms of ferroptosis, and it has been confirmed that ferroptosis plays a pivotal role in the pathophysiological processes of various diseases, including tumors, inflammation, neurodegenerative diseases, and infectious diseases. The pancreas, which is the second largest digestive gland in the human body and has both endocrine and exocrine functions, is a vital organ for controlling digestion and metabolism.

Association of metabolic syndrome and its components with the risk of urologic cancers: a prospective cohort study.

Objective: To investigate the association between metabolic syndrome (MetS) and its components and the risk of developing urologic cancers.

Methods: This study included 101,510 observation subjects from May 2006 to December 2007. The subjects received questionnaires and were subjected to clinical and laboratory examinations to collect data on baseline population characteristics, waist circumference (WC), blood pressure (BP), blood glucose, blood lipids, lifestyle, and past disease history.

Validation of the commercial coronary computed tomographic angiography artificial intelligence for coronary artery stenosis: a cross-sectional study.

Background: The commercial coronary computed tomographic angiography artificial intelligence (CCTA-AI) platform has made great progress in clinical application. However, research is needed to elucidate the current stage of commercial AI platforms and the role of radiologists. This study compared the diagnostic performance of the commercial CCTA-AI platform with that of a reader based on a multicenter and multidevice sample.

Association of education level with the risk of female breast cancer: a prospective cohort study.

Background: Breast cancer is a serious threat to female health, and its incidence varies with education level (EL). In the present study, the association between EL and the risk of developing female breast cancer was investigated.

Methods: From May 2006 to December 2007, 20,400 observation subjects in Kailuan Cohort received questionnaires and were subjected to clinical examinations for data collection on baseline population characteristics, height, weight, lifestyle and past disease history.

Topological super-modes engineering with acoustic graphene plasmons.

Acoustic graphene plasmons (AGPs) in a graphene-dielectric-metal structure possess extreme field localization and low loss, which have promising applications in strong photon-matter interaction and integrated photonic devices. Here, we propose two kinds of one-dimensional crystals supporting propagating AGPs with different topological properties, which is confirmed by the Zak phase calculations and the electric field symmetry analysis. Moreover, by combining these two plasmonic crystals to form a superlattice system, the super-modes exist because of the coupling between isolated topological interface states.

Understanding Synergistic Catalysis on Cu-Se Dual Atom Sites via Operando X-ray Absorption Spectroscopy in Oxygen Reduction Reaction.

The construction and understanding of synergy in well-defined dual-atom active sites is an available avenue to promote multistep tandem catalytic reactions. Herein, we construct a dual-hetero-atom catalyst that comprises adjacent Cu-N and Se-C active sites for efficient oxygen reduction reaction (ORR) activity. Operando X-ray absorption spectroscopy coupled with theoretical calculations provide in-depth insights into this dual-atom synergy mechanism for ORR under realistic device operation conditions.

Efficacy Evaluation of 64-Slice Spiral Computed Tomography Images in Laparoscopic-Assisted Distal Gastrectomy for Gastric Cancer under the Reconstruction Algorithm.

This study was aimed to analyze the application value of the filtered back-projection (FBP) reconstruction algorithm of computed tomography (CT) images in laparoscopic-assisted distal gastrectomy. In this study, 56 patients with gastric cancer were selected as research subjects and randomly divided into the control group (CT-guided laparoscopic radical gastrectomy) and the observation group (CT-guided laparoscopic radical gastrectomy with the FBP reconstruction algorithm), with 28 patients in each group. Fourier transform and iterative reconstruction were introduced for comparison, and finally, the postoperative curative effect and adverse events were compared between the two groups.

A Smart Multi-Rate Data Fusion Method for Displacement Reconstruction of Beam Structures.

Dynamic displacement plays an essential role in structural health monitoring. To overcome the shortcomings of displacement measured directly, such as installation difficulty of monitoring devices, this paper proposes a smart reconstruction method, which can realize real-time intelligent online reconstruction of structural displacement. Unlike the existing approaches, the proposed algorithm combines the improved mode superposition methods that is suitable for complex beam structures with the Kalman filtering approach using acceleration and strain data.

Patient-derived micro-organospheres enable clinical precision oncology.

Patient-derived xenografts (PDXs) and patient-derived organoids (PDOs) have been shown to model clinical response to cancer therapy. However, it remains challenging to use these models to guide timely clinical decisions for cancer patients. Here, we used droplet emulsion microfluidics with temperature control and dead-volume minimization to rapidly generate thousands of micro-organospheres (MOSs) from low-volume patient tissues, which serve as an ideal patient-derived model for clinical precision oncology.

Dual-triggered biomimetic vehicles enable treatment of glioblastoma through a cancer stem cell therapeutic strategy.

Glioma stem cells (GSCs) and their complex microenvironment play a crucial role in the high invasion of cancer and therapeutic resistance and are considered to be the most likely cause of cancer relapse. We constructed a biomimetic vehicle (LDL-SAL-Ang) based on a low density lipoprotein triggered by Angiopep-2 peptide and ApoB protein, to improve the transport of an anti-GSC therapeutic agent into the brain. The LDL-SAL-Ang showed significant inhabitation for GSC microsphere formation and induced the highest apoptotic rate in two types of GSCs.

Expression changes of IL-17 in zoledronic acid combined with PVP technology in the treatment of postmenopausal osteoporotic vertebral compression fracture and its predictive value of relapse.

Objective: To investigate the expression of interleukin-17 (IL-17) in zoledronic acid combined with PVP technology for patients with postmenopausal osteoporotic vertebral compression fracture (OVCF) and its predictive value for relapse.

Methods: 101 OVCF patients treated in our hospital from April 2013 to January 2015 were collected as a research group and treated by zoledronic acid combined with PVP technology. 80 healthy people with physical examination were assigned to the control group.

Reactivity Improvement of Ca-Based CO Absorbent Modified with Sodium Humate in Cyclic Calcination/Carbonation.

The Ca-based sorbent cyclic calcination/carbonation reaction (CCCR) is a high-efficiency technique for capturing CO from combustion processes. The CO capture ability of CaO modified with sodium humate (HA-Na) (HA-Na/CaO) in long-term calcination/carbonation cycles was investigated. The enhancement mechanism of HA-Na on CCCR was proposed and demonstrated.

Low optical dosage heating-reduced viscosity for fast and large-scale cleanup of spilled crude oil by reduced graphene oxide melamine nanocomposite adsorbents.

Heating under low solar radiation intensity is demonstrated to facilitate the cleaning of crude oil by the hydrophobic nanocomposite adsorbents of reduced graphene oxide (RGO) melamine sponge (MS@RGO) foams. The heat generated by the irradiation reduces the viscosity of the crude oil, and consequently increases the oil-diffusion coefficient of the pores of the MS@RGO foams and speeds up the oil-sorption rate. Even under a solar radiation intensity as low as 2 kW m, the temperature of crude oil rapidly rises to 68 °C or higher within 10 min.

Correction: Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy.

[This corrects the article DOI: 10.1371/journal.ppat.

NIR-Responsive Copolymer Upconversion Nanocomposites for Triggered Drug Release in Vitro and in Vivo.

Light has several advantages as the stimulus for a triggered drug release. Currently, the applications of phototriggered drug-release devices (PDDs) are largely limited by two factors: the limited tissue penetration and detrimental effects caused by excitation light (ultraviolet or visible light). To address this disadvantage, this study developed nanocomposites based on upconversion nanoparticles (UC), which could convert near-infrared light to ultraviolet-visible light and trigger drug release.