Sustained yet non-curative response to lenalidomide in relapsed angioimmunoblastic T-cell lymphoma with acquired chidamide resistance: a case report with 10-year follow-up, genetic insights and literature review.

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphoma (PTCL) characterized by its T-follicular helper (TFH) phenotype. Relapsed and refractory disease is common in AITL and often associated with a poor prognosis. The presence of epigenetic abnormalities, immune dysregulation, hyperinflammation and active angiogenesis in AITL offers potential targets for histone deacetylase (HDAC) inhibitors and immunomodulatory drugs (IMiDs).

A composite scaling network of EfficientNet for improving spatial domain identification performance.

Spatial Transcriptomics leverages gene expression profiling while preserving spatial location and histological images. However, processing the vast and noisy image data in spatial transcriptomics (ST) for precise recognition of spatial domains remains a challenge. In this study, we propose a method of EfNST for recognizing spatial domains, which employs an efficient composite scaling network of EfficientNet to learn multi-scale image features.

Detecting optical frequency in weak signal light using injection-induced frequency modulation.

In fiber-optic sensing, long-distance transmission and demodulation of weak signal light (SL) are critical. This study improves the system by relocating an external cavity tunable laser (ECTL) to the transmission end. Directly injecting the SL into the ECTL modulates the output light and uses the high-power ECTL light for transmission, reducing loss.

Phase extraction method resistant to the nonlinearity for dynamic frequency scanning interferometry.

Dynamic frequency scanning interferometry (DFSI) offers the advantage of drift immunity in distance measurements, making it widely used in industrial applications. However, the nonlinear scanning characteristics of lasers can induce non-stationarity in interference signals, complicating the phase extraction process and decreasing the accuracy of dynamic distance measurement. This study investigates the phase extraction of non-stationary signals with multiple frequency components and proposes a second-order group delay error compensation algorithm.

Tryptophan Metabolism-Regulating Probiotics Alleviate Hyperuricemia by Protecting the Gut Barrier Integrity and Enhancing Colonic Uric Acid Excretion.

The balance of gut microbiota affects uric acid synthesis and excretion, influencing the development of hyperuricemia. This study aimed to investigate the effects and mechanisms of probiotics on hyperuricemia and adenine- and potassium oxonate-induced colonic damage. After two months of gavage at 10 CFU/day, the probiotic strains UA260 and YU28, identified through screening, significantly reduced serum uric acid levels in hyperuricemia mice from 109.

Eliciting medication preferences of patients with type 2 diabetes under different insurance coverages in China.

Objective: To understand the medication preference of type 2 diabetes mellitus (T2DM) patients with different insurance coverages, and to provide reference for improving the patient-centered clinical treatment decision.

Methods: This study used Discrete Choice Experiment (DCE) to elicit preferences of T2DM patients with different insurance coverages in China. A multistage stratified cluster-sampling procedure for data collection and a total of 1,409 valid respondent were conducted.

Utilizing Waste Biomass from Agricultural and Forestry Sustainable Resources: Biomass Conversion to Functional Adsorbent Material for Efficient Removal of Total Phosphate in Practical Water.

The promotion of the utilization of waste agricultural and forestry resources (AFRs) as a means of combating environmental pollution represents an advanced and necessary development approach with the potential to achieve sustainable development. In this work, an advanced adsorbent with a functional Mg-Al bimetallic layer was prepared using waste sawdust biomass (WSD) as a raw material. The layer serves as the primary active component for adsorbing total phosphate from both simulated and real wastewater.

Risk Factors of Postoperative Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting Surgery in the Recent 10 Years: Clinical Analysis of 6229 Patients.

Background: Postoperative atrial fibrillation (POAF) is a common complication after coronary artery bypass grafting (CABG) that prolongs hospitalization and increases expenses.

Hypothesis: Perioperative risk factors may predict POAF.

Methods: From March 2015 to January 2023, 6229 patients who underwent isolated CABG and were in sinus rhythm before CABG were included in this retrospective study.

Methionine restriction alleviates diabetes-associated cognitive impairment via activation of FGF21.

Glucose metabolism disturbances may result in diabetes-associated cognitive decline (DACI). Methionine restriction (MR) diet has emerged as a potential dietary strategy for managing glucose homeostasis. However, the effects and underlying mechanisms of MR on DACI have not been fully elucidated.

Myelin oligodendrocyte glycoprotein-associated transverse myelitis after SARS-CoV-2 infection: A case report.

Background: Cases of myelin oligodendrocyte glycoprotein (MOG) antibody-related disease have a history of coronavirus disease 2019 infection or its vaccination before disease onset. Severe acute respiratory syndrome virus 2 (SARS-CoV-2) infection has been considered to be a trigger of central nervous system autoimmune diseases.

Case Summary: Here we report a 20-year male with MOG-associated transverse myelitis after a SARS-CoV-2 infection.

Cobalt and nitrogen co-doped hollow periodic mesoporous organosilica spheres activated by potassium chloride for selective oxidation of ethylbenzene.

Enhancing the exposure of metal active sites and maximizing metal atom utilization are critical challenges in heterogeneous catalysis. To solve these issues, heterogeneous catalysts are usually activated by chemicals. Herein, potassium chloride (KCl) was used as an activator to prepare cobalt-nitrogen co-doped (Co-N) hollow periodic mesoporous organosilica spheres (Co-N/HPMOs-KCl).

Liquid Biopsy-Based Accurate Diagnosis and Genomic Profiling of Hard-to-Biopsy Tumors via Parallel Single-Cell Genomic Sequencing of Exfoliated Tumor Cells.

Liquid biopsy provides a convenient and safer procedure for the diagnosis and genomic profiling of tumors that are inaccessible to biopsy by analyzing exfoliated tumor cells (ETCs) or tumor-derived cell-free DNA (cfDNA). However, its primary challenge lies in its limited accuracy in comparison to tissue-based approaches. We report a parallel single-ETC genomic sequencing (Past-Seq) method for the accurate diagnosis and genomic profiling of hard-to-biopsy tumors such as cholangiocarcinoma (CCA) and upper tract urothelial carcinoma (UTUC).

Behavioral dysregulation in Nile tilapia (Oreochromis niloticus, GIFT) post-Streptococcus agalactia infection: Role of the microbiota-gut-brain axis.

In the aquatic farming industry, understanding the factors affecting fish behavior is crucial, particularly in response to infections that compromise welfare and productivity. Swimming performance is a key life history trait critical to their ecology. This study explores the swimming behavior imbalance in Nile tilapia (Oreochromis niloticus, GIFT) post-infection with Streptococcus agalactiae (GBS), a common pathogen responsible for significant losses in aquaculture.

The architecture of functional brain network modulated by driving under train running noise exposure.

A noisy environment can considerably impact drivers' attention and fatigue, endangering driving safety. Consequently, this study designed a simulated driving experimental scenario to analyse the effects of noise generated during urban rail transit train operation on drivers' functional brain networks. The experiment recruited 16 participants, and the simulated driving scenario was conducted at noise levels of 50, 60, 70, and 80 dB.

Secoisolariciresinol diglucoside attenuates neuroinflammation and cognitive impairment in female Alzheimer's disease mice via modulating gut microbiota metabolism and GPER/CREB/BDNF pathway.

Background: Gender is a significant risk factor for late-onset Alzheimer's disease (AD), often attributed to the decline of estrogen. The plant estrogen secoisolariciresinol diglucoside (SDG) has demonstrated anti-inflammatory and neuroprotective effects. However, the protective effects and mechanisms of SDG in female AD remain unclear.

Baricitinib alleviates cardiac fibrosis and inflammation induced by chronic sympathetic activation.

Cardiac fibrosis is characterized by the over-proliferation, over-transdifferentiation and over-deposition of extracellular matrix (ECM) of cardiac fibroblasts (CFs). Cardiac sympathetic activation is one of the leading causes of myocardial fibrosis. Meanwhile, cardiac fibrosis is often together with cardiac inflammation, which accelerates fibrosis by mediating inflammatory cytokines secretion.

Discovery of delayed gas production after implantation of a continuous-flow left ventricular assist device and a preliminary exploration of the mechanisms of its occurrence.

Objective: To characterize the gas production phenomenon in the animal model of left ventricular assist device (LVAD), and study its mechanism.

Methods: An bubble precipitation experiment was conducted, and the blood samples of Parma spp. animals were divided into ordinary group and oxygen-enriched group according to whether they were oxygenated or not at the time of blood collection, and a static control group was set up respectively.

MHC-I-presented non-canonical antigens expand the cancer immunotherapy targets in acute myeloid leukemia.

Identification of tumor neoantigens is indispensable for the development of cancer immunotherapies. However, we are still lacking knowledge about the potential neoantigens derived from sequences outside protein-coding regions. Here, we comprehensively characterized the immunopeptidome landscape by integrating multi-omics data in acute myeloid leukemia (AML).