Application of silk fibroin-based composite films in biomedicine and biotechnology.

Silk fibroin has garnered significant attention as a natural biomaterial due to its exceptional biocompatibility, tunable water solubility, optical transparency and high thermal stability. In recent years, silk fibroin films have gained prominence for their ease of fabrication and unique properties. However, their intrinsic brittleness limits broader applicability in certain fields.

Application of nirmatrelvir/ritonavir for the treatment of severe COVID-19 in a 3-year-old child.

Introduction: Nirmatrelvir/ritonavir (Paxlovid) is an effective antiviral drug for treating coronavirus disease 2019 (COVID-19) in adults. However, Paxlovid treatment of children, especially those who are under 12 years and with severe underlying diseases, is rare.

Case Report: A three-year-old COVID-19 patient (weighing 14.

Associations between maternal gestational diabetes mellitus and offspring cerebral palsy: a two-sample Mendelian randomization study.

Background: Observational studies on the association between gestational diabetes mellitus (GDM) during pregnancy and pediatric neurological disorders (PNDs) such as cerebral palsy (CP), autism spectrum disorders (ASD), and epilepsy (EP) in offspring have yielded mixed findings, creating ambiguity in causal interpretations. The direct link between GDM and these PNDs remains unclear. Elucidating this connection is vital for developing effective early intervention strategies during pregnancy to mitigate the risk of PNDs in the offspring.

Investigation of the catch-up status and termination for corrected age of neurodevelopment in premature infants of different gestational ages.

Background: Corrected age entails determining the age of premature infants by adjusting their gestational age to 40 weeks. Research on corrected age in relation to neurodevelopment is limited, both domestically and internationally, resulting in a lack of consensus and recommendations regarding the appropriate termination of the neurodevelopmental corrected age. This study aimed to assess the neurodevelopmental catch-up status of premature infants with varying gestational ages and to identify appropriate termination criteria for the corrected age of neurodevelopment.

[Neurodevelopmental catch-up status and correction termination age in preterm infants of different gestational ages].

Objectives: To investigate the status of neurodevelopmental catch-up and suitable correction termination age in preterm infants of different gestational ages.

Methods: A total of 918 preterm infants without significant high-risk factors who attended the outpatient service of the Second Affiliated Hospital of Army Medical University from January 1, 2018 to March 1, 2023 were included. The data on developmental quotient (DQ) in Gesell Developmental Schedule (GDS) were collected, while 6 684 full-term infants were included as controls.

The effectiveness of therapist-led family-centered language intervention for children with language delay.

Background: China's language therapist shortage and intergenerational caregiving trends underscore the need for family-based language training, yet such interventions are underutilized and family roles undervalued. This study aims to investigate the effect of a therapist-led family-centered intervention on children with language delay.

Methods: The study comprised 134 children, comprising 59 girls and 75 boys, aged between 2 and 5 years (39.

Prediction of storage years of Wuyi rock tea Shuixian by metabolites analysis.

Wuyi rock teas of different storage duration have different flavor, bioactivity, and market value, Shuixian is a main variety of Wuyi rock tea. In this study, metabolites composition of Shuixian with different storage years were analyzed using Ultrahigh Performance Liquid Chromatography-Quadrupole-Time of Flight-Mass Spectrometry (UPLC-Q-TOF-MS). A total of 1201 compounds were identified, and 104 differential compounds (VIP > 1.

Evaluating wetland ecosystem services value and dominant functions: Insights from the Pearl River Delta.

Weakening wetland ecosystem services (ES) significantly hinders the achievement of the Sustainable Development Goals (SDGs). It is essential to combine multiple methods for evaluating wetland ecosystem services value (ESV) and to clearly depict the spatial distribution of ESVs. Based on the local conditions of the Pearl River Delta (PRD), this study proposed a monetary evaluation system for wetland ESV, developed a method for spatially allocating individual ESVs, and identified the dominant wetland functions across different cities and types of wetlands.

Island biogeography theory and the habitat heterogeneity jointly explain global patterns of diversity.

Mountain biodiversity is of great importance to biogeography and ecology. However, it is unclear what ecological and evolutionary processes best explain the generation and maintenance of its high levels of species diversity. In this study, we determined which of six common hypotheses (e.

Electroacupuncture activates the peroxisome proliferators-activated receptor pathway to improve the phenotype of cerebral palsy.

Aim: This study explores the efficacy of electroacupuncture (EA) in treating cerebral palsy (CP) in Sprague-Dawley (SD) pups, specifically CP animal models, and its molecular mechanisms.

Methods: Gait analysis and Y-maze were used to detect the improvement of motor ability and cognitive function of CP rats after EA treatment. Transcription sequencing was used to determine the key pathway for EA to improve the symptoms of CP.

Colonization of microbiota derived from s, Bama miniature pigs, beagle dogs, and C57BL/6J mice alleviates DSS-induced colitis in germ-free mice.

Fecal microbiota transplantation (FMT) is an innovative and promising treatment for inflammatory bowel disease (IBD), which is related to the capability of FMT to supply functional microorganisms to improve recipient gut health. Numerous studies have highlighted considerable variability in the efficacy of FMT interventions for IBD. Several factors, including the composition of the donor microorganisms, significantly affect the efficacy of FMT in the treatment of IBD.

Exploration of effective biomarkers for venous thrombosis embolism in Behçet's disease based on comprehensive bioinformatics analysis.

Behçet's disease (BD) is a multifaceted autoimmune disorder affecting multiple organ systems. Vascular complications, such as venous thromboembolism (VTE), are highly prevalent, affecting around 50% of individuals diagnosed with BD. This study aimed to identify potential biomarkers for VTE in BD patients.

LINC01535 promotes hepatocellular carcinoma proliferation and metastasis by regulating the miR-214-3p/VASP axis.

Emerging evidence has indicated that long noncoding RNAs (lncRNAs) are associated with the development and progression of several carcinomas, including hepatocellular carcinoma (HCC). However, the role of LINC01535 in HCC is still unknown. In this study, RNA-seq, CCK-8, colony formation, wound healing, Transwell and tumor xenograft assays were used to explore the function of LINC01535 in the proliferation and metastasis of HCC and .

The clinical effects of Orff music therapy on children with autism spectrum disorder: a comprehensive evaluation.

Objective: This study aimed to investigate the clinical effects of Orff music therapy on children with Autism Spectrum Disorder (ASD) from the perspectives of parents, evaluators, and therapists.

Methods: 93 children with ASD aged 3-6 years participated in the study. They were divided into an observation group ( = 48) receiving comprehensive rehabilitation intervention including Orff music therapy, and a control group ( = 45) receiving only comprehensive rehabilitation intervention.

Facility for spectral radiance calibration at low light level.

The spectral radiance measurement at daytime level can be realized with high accuracy, while it's difficult when the spectral radiance is at nighttime level. We design a spectral radiance calibration facility which has the characteristics of completely unchanged spectrum over 3 orders of magnitude and approximately unchanged spectrum for about 6 orders of magnitude. It combines a spectral radiance light source, a precision aperture and a white diffuser together, make it easy to reproduce the spectral radiance at 380 nm from 4 × 10 W/(m·sr·nm) to 4 × 10 W/(m·sr·nm).

[Research progress on the dynamic role and intervention value of autophagy in neonatal hypoxic-ischemic brain damage].

The repair of the nervous system after hypoxic-ischemic brain damage (HIBD) in neonates lacks specific therapeutic approaches, posing a challenge and hot topic in the medical field. Autophagy, as a cellular self-repair mechanism, plays a role through different signaling pathways at different stages, yet its specific roles and mechanisms in different stages of HIBD remain unclear. This article reviews the recent research advancements on autophagy in different neonatal HIBD stages: heightened autophagic activity manifests during the acute hypoxic-ischemic phase, with its neuroprotective or deleterious impact subject to ongoing debate; during the subacute and chronic phases, autophagy exert dual effects on neuronal death and repair; in sequelae period, autophagy-related studies are still insufficient, but the expression levels of autophagy-related genes (ATG) in children with cerebral palsy suggest both positive and negative aspects of autophagy post-HIBD.

Assessment of the role of false-positive alerts in computer-aided polyp detection for assistance capabilities.

Background And Aim: False positives (FPs) pose a significant challenge in the application of artificial intelligence (AI) for polyp detection during colonoscopy. The study aimed to quantitatively evaluate the impact of computer-aided polyp detection (CADe) systems' FPs on endoscopists.

Methods: The model's FPs were categorized into four gradients: 0-5, 5-10, 10-15, and 15-20 FPs per minute (FPPM).

Validation of artificial intelligence-based bowel preparation assessment in screening colonoscopy (with video).

Background And Aims: Accurate bowel preparation assessment is essential for determining colonoscopy screening intervals. Patients with suboptimal bowel preparation are at a high risk of missing >5 mm adenomas and should undergo an early repeat colonoscopy. In this study, we used artificial intelligence (AI) to evaluate bowel preparation and validated the ability of the system to accurately identify patients who are at high risk of having >5 mm adenomas missed due to inadequate bowel preparation.

Multistep validation of a post-ERCP pancreatitis prediction system integrating multimodal data: a multicenter study.

Background And Aims: The impact of various categories of information on the prediction of post-ERCP pancreatitis (PEP) remains uncertain. We comprehensively investigated the risk factors associated with PEP by constructing and validating a model incorporating multimodal data through multiple steps.

Methods: Cases (n = 1916) of ERCP were retrospectively collected from multiple centers for model construction.

Extracellular vesicles derived from Lactobacillus johnsonii promote gut barrier homeostasis by enhancing M2 macrophage polarization.

Introduction: Diarrheic disease is a common intestinal health problem worldwide, causing great suffering to humans and animals. Precise manipulation strategies based on probiotics to combat diarrheic diseases have not been fully developed.

Objectives: The aim of this study was to investigate the molecular mechanisms by which probiotics manipulate macrophage against diarrheic disease.