The Causal Relationship Between Acne Vulgaris and BMI: A Mendelian Randomization Study.

Background: As an inflammatory skin condition, acne usually presents with a complex pathogenesis. Recent studies suggest that BMI may relate to the incidence of acne. Mendelian randomization is a statistical method that is used to evaluate the causal effects of exposure factors on outcome variables.

Amorphous/Crystalline Interface of Bi/BiNbOCl Heterostructure for Improved Piezo-Photocatalysis.

Efficient separation of photogenerated charges at the surface of photocatalysts is vital for achieving high photocatalytic activity. Here, a Bi/BiNbOCl heterostructure piezo-photocatalyst with an amorphous/crystalline interface (acBi/BNC) is prepared by in situ reduction using BiNbOCl as a self-sacrificial template. This ingenious design synergistically utilizes the advantages of the amorphous/crystalline interface structure, localized surface plasmon resonance effect, and piezoelectric field.

Structural and functional changes in the oral microbiome of patients with craniofacial microsomia.

Craniofacial microsomia (CFM) is the second most common congenital craniofacial deformity, presenting diverse clinical manifestations and treatments that may influence oral bacteria dysbiosis (OBD). However, research linking CFM to OBD is limited. Saliva samples were collected from 20 patients with CFM and 24 controls.

Identification of Chemical Constituents and Rat Metabolites of Jianpihuazhuotiaozhi Granule by Ultra-High-Performance Liquid Chromatography Coupled With Quadrupole-Time-of-Flight Mass Spectrometry.

Jianpihuazhuotiaozhi granules (JPHZTZ) are traditional Chinese medicine formula. An analytical method using ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry was established to characterize the chemical constituents of JPHZTZ and determine its metabolic profile in rat urine and plasma after oral administration. A total of 220 compounds were identified in JPHZTZ extract, including 61 flavonoids, 16 alkaloids, 53 organic acids, 31 terpenoids, and 59 other compounds.

Identification and validation of a novel signature based on immune‑related genes from epithelial cells to predict prognosis and treatment response in patients with lung squamous cell cancer by integrated analysis of single‑cell and bulk RNA sequencing.

Epithelial cells are associated with tumor immunity through interstitial transformation, yet the role of epithelial immune-related genes (EIGs) in this process remains unclear. Comprehending the mechanisms behind EIGs within lung squamous cell carcinoma (LUSC) may offer an explanation to these issues. The present study aimed to explore the biological role of EIGs in patients with LUSC.

Evolutionary dynamics of SARS-CoV-2 variants under strict non-pharmaceutical interventions - a population-based study.

Introduction: China implemented a dynamic zero-COVID strategy to curb viral transmission in response to the coronavirus disease 2019 (COVID-19) pandemic. This strategy was designed to inhibit mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19. This study explores the dynamics of viral evolution under stringent non-pharmaceutical interventions (NPIs) through real-world observations.

A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma.

Background: Disease progression within 24 months (POD24) significantly impacts overall survival (OS) in patients with follicular lymphoma (FL). This study aimed to develop a robust predictive model, FLIPI-C, using a machine learning approach to identify FL patients at high risk of POD24.

Methods: A cohort of 1,938 FL patients (FL1-3a) from seventeen centers nationwide in China was randomly divided into training and internal validation sets (2:1 ratio).

Construction of Full-Spectrum-Response BiOBr:Er@BiO S-Scheme Heterojunction With [Bi─O] Tetrahedral Sharing by Integrated Upconversion and Photothermal Effect Toward Optimized Photocatalytic Performance.

Designing and optimizing photocatalysts to maximize the use of sunlight and achieve fast charge transport remains a goal of photocatalysis technology. Herein, a full-spectrum-response BiOBr:Er@BiO core-shell S-scheme heterojunction is designed with [Bi─O] tetrahedral sharing using upconversion (UC) functionality, photothermal effects, and interfacial engineering. The UC function of Er and plasmon resonance effect of BiO greatly improves the utilization of sunlight.

Construction of a 0D-2D-2D Sandwich-like Ag/g-CN/MoS Photocatalyst with Bidirectional Electron Transfer Channels for Photocatalytic Hydrogen Evolution.

Hydrogen (H) production technology has sparked a boom in research aimed at alleviating environmental pollution and the pressure of nonrenewable energy sources. A key factor in this technology is the use of efficient photocatalysts. In this work, we successfully synthesized a 0D-2D-2D sandwich-like Ag/g-CN/MoS catalyst with bidirectional electron transfer channels via a calcination-hydrothermal method.

Genomic Insights into Antibiotic Resistance and Virulence of Isolated from Chongqing, China.

() is a pathogen of significant concern in food due to its ability to survive and multiply under harsh environmental conditions, such as high osmotic pressure, low temperatures, and freezing. This bacterium can cause listeriosis, a severe infection particularly dangerous for high-risk groups including newborns, pregnant women, and immunocompromised patients, due to its high morbidity and mortality rates. This study aimed to investigate the molecular epidemiological characteristics of isolated in Chongqing, southwest China.

Changes of T cell subsets across treatments associated with prognosis in newly diagnosed follicular lymphoma.

Follicular lymphoma (FL) is an immune-responsive tumor with spontaneous remission. T cells play a pivotal role in the anti-lymphoma immune response. However, the dynamics of T cells during treatment, their impact on FL clinical outcomes, and the risk factors contributing to T-cell cytopenia remain largely unexplored.

Evolution of hydrochemistry and water quality of karst groundwater under the effects of intense anthropogenic activities.

Intense anthropogenic activities in a karst area will inevitably change the regional groundwater environment and affect the characteristics of the karst groundwater, such as the hydrochemistry and water quality. It is of great importance to study the evolution characteristics of the hydrochemistry and water quality of karst groundwater under intense anthropogenic activities to ensure the stability and sustainable development of karst ecosystems. In this study, a representative synclinal basin-type karst groundwater system in northern China was used as the study object, and the effects of intense anthropogenic activities on the evolution of the hydrochemistry and water quality of the karst groundwater were analyzed using a comprehensive application of a groundwater quality assessment, a multivariate statistical analysis, a hydrogeochemical analysis, and multi-factor regime monitoring of the karst groundwater quality.

FHOD3 Promotes the Progression of Lung Cancer by Regulating the Caspase-3-Mediated Signaling Pathway.

Introduction/objective: Lung cancer causes hundreds of thousands of deaths each year worldwide. FHOD3 was reported to accelerate the progression of brain cancer. However, its role in lung cancer is not clear.

Altitude and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in China: A Population-Based Study.

Yufei Wang, Qiong Meng, Jin Zhang, Bing Guo, Nanyan Li, Qian Deng, Julinling Hu, Deji Quzong, Han Guan, Danzhen Wangjiu, Hui Yu, Zhifeng Li, and Junmin Zhou. Altitude and metabolic dysfunction-associated fatty liver disease (MAFLD) in China: a population-based study. 00:00-00, 2024.

Peroral choledochoscope for anterograde bridging of biliary drainage via T-tube.

Postoperative biliary stricture after biliary surgery is a challenging condition. Biliary stent placement by endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) are the effective treatment for biliary stricture. We report a case of peroral choledochoscope was used for anterograde bridging of biliary drainage via T-tube.

Theoretical study on the luminescent and reaction mechanism of dansyl-based fluorescence probe for detecting hydrogen sulfide.

The photophysical and photochemical properties of the sulfonyl azide-based fluorescent probe DNS-Az and its reduction product DNS by hydrogen sulfide (HS) have been investigated theoretically. The calculated results indicated the first excited states of DNS-Az was dark state (oscillator strength less than 0.03) and DNS was bright state (oscillator strength more than 0.

Ribosomal translation of fluorinated non-canonical amino acids for biologically active fluorinated macrocyclic peptides.

Fluorination has emerged as a promising strategy in medicinal chemistry to improve the pharmacological profiles of drug candidates. Similarly, incorporating fluorinated non-canonical amino acids into macrocyclic peptides expands chemical diversity and enhances their pharmacological properties, from improved metabolic stability to enhanced cell permeability and target interactions. However, only a limited number of fluorinated non-canonical amino acids, which are canonical amino acid analogs, have been incorporated into macrocyclic peptides by ribosomes for construction and target-based screening of fluorinated macrocyclic peptides.

Clinical efficacy of CO fractional laser combined with compound betamethasone in treating vitiligo and its impact on inflammatory factors.

Objective: To analyze the clinical efficacy of CO fractional laser combined with compound betamethasone in treating vitiligo and its impact on inflammatory factors.

Methods: The clinical treatment effects, levels of inflammatory factors [interleukin-17 (IL-17), interferon-gamma (IFN-γ), interleukin-10 (IL-10)], prognosis regarding repigmentation and relapse, psychological health (satisfaction).

Results: ① Clinical treatment effects: the total effective rate in Group A was 92.

EGFR kinase domain duplication in lung adenocarcinoma with systemic and intracranial response to a double-dose of furmonertinib: a case report and literature review.

Background: EGFR kinase domain duplication (EGFR-KDD) is an infrequent oncogenic driver mutation in lung adenocarcinoma. It may be a potential target benefit from EGFR-tyrosine kinase inhibitors (TKIs) treatment.

Case Presentation: A 66-year-old Chinese male was diagnosed with lung adenocarcinoma in stage IVb with brain metastases.

Investigation on activation characterization, secondary electron yield, and surface resistance of novel quinary alloy Ti-Zr-V-Hf-Cu non-evaporable getters.

The performance of next-generation particle accelerators has been adversely affected by the occurrence of electron multipacting and vacuum instabilities. Particularly, minimization of secondary electron emission (SEE) and reduction of surface resistance are two critical issues to prevent some of the phenomena such as beam instability, reduction of beam lifetime, and residual gas ionization, all of which occur as a result of these adverse effects in next-generation particle accelerators. For the first time, novel quinary alloy Ti-Zr-V-Hf-Cu non-evaporable getter (NEG) films were prepared on stainless steel substrates by using the direct current magnetron sputtering technique to reduce surface resistance and SEE yield with an efficient pumping performance.

[The Effecacy and Safety of Daratumumab Based Regimens in Relapsed/Refractory Multiple Myeloma: A Single-Center Real-World Data Analysis].

Objective: To investigate the efficacy and safety of daratumumab based regimens in relapse and/or refractory multiple myeloma (RRMM) in the real world, as well as the impact of daratumumab on stem cell collection and engraftment.

Methods: The clinical data of patients with RRMM who received daratumumab in hematology department of the First Affiliated Hospital of Xiamen University from February 2019 to March 2023 and had evaluable efficacy were retrospective analysis.

Results: All 43 RRMM patients were treated with daratumumab-based combination regimens, including Dd, DVd, DRd, Dkd, DId, and Dara-DECP.

Ribosomal Incorporation of Lithocholic Acid into Peptides for the Discovery Of Peptide-Lithocholic Acid Hybrid Macrocyclic Peptides.

Peptide-bile acid hybrids offer promising drug candidates due to enhanced pharmacological properties, such as improved protease resistance and oral bioavailability. However, it remains unknown whether bile acids can be incorporated into peptide chains by the ribosome to produce a peptide-bile acid hybrid macrocyclic peptide library for target-based screening. In this study, we achieved the ribosomal incorporation of lithocholic acid (LCA)-d-tyrosine into peptide chains.