Clinicopathological characteristics and value of HER2-low expression evolution in breast cancer receiving neoadjuvant chemotherapy.

Objective: The present study aimed to evaluate the clinicopathological characteristics and value of HER2-low expression evolution in breast cancer receiving neoadjuvant chemotherapy (NAC).

Methods: Patients with HER2 negative breast cancer receiving NAC from January 2017 to December 2020 were enrolled in this study. The clinicopathological characteristics, response to NAC, evolution of HER2 and prognostic value were retrospectively analyzed.

Two-dimensional MN materials as effective multifunctional electrocatalysts for the hydrogen-evolution, oxygen-evolution, and oxygen-reduction reactions.

Two-dimensional (2D) materials confining single atoms (SAs) for catalysis, such as graphene confining metal single atoms (M-N-C), integrate both aspects of 2D materials and single-atom catalysts (SACs). Significant advantages have been established in this new category of catalysts, which have seen rapid development in recent years. Recent studies have suggested a new class of novel 2D materials with a chemical formula of MN naturally holding a uniformly distributed M-N moiety.

Extension of the TraPPE Force Field for Battery Electrolyte Solvents.

Optimizing electrolyte formulations is key to improving performance of Li-/Na-ion batteries, where transport properties (diffusion coefficient, viscosity) and permittivity need to be predicted as functions of temperature, salt concentration and solvent composition. More efficient and reliable simulation models are urgently needed, owing to the high cost of experimental methods and the lack of united-atom molecular dynamics force fields validated for electrolyte solvents. Here the computationally efficient TraPPE united-atom force field is extended to be compatible with carbonate solvents, optimizing the charges and dihedral potential.

HER2-low expression does not affect the clinical outcomes of metastatic breast cancer treated with CDK4/6 inhibitor: A real-world study.

Background: There is accumulating evidence support human epidermal growth factor receptor 2 ()-low as a biologically distinct subtype of breast cancer. The present study was conducted to explore whether -low expression will affect the clinical efficacy of cyclin-dependent kinase () 4/6 inhibitor for patients with hormone receptor (HR)-positive, negative metastatic breast cancer.

Methods: Patients with HR+/- metastatic breast cancer who were treated with palbociclib from January 2019 to June 2021 were retrospectively analyzed based on real-world clinical practice.

A real-world study of anlotinib as third-line or above therapy in patients with her-2 negative metastatic breast cancer.

Background: Antiangiogenic agents provides an optional treatment strategy for patients with metastatic breast cancer. The present study was conducted to evaluate the efficacy and safety of anlotinib as third-line or above therapy for patients with HER-2 negative metastatic breast cancer.

Methods: Patients with HER-2 negative metastatic breast cancer who have failed from prior therapy and treated with anlotinib monotherapy or combined with chemotherapy or immunotherapy from June 2018 to December 2020 were retrospectively analyzed based on real-world clinical practice.

Clinical, Pathological Complete Response, and Prognosis Characteristics of HER2-Low Breast Cancer in the Neoadjuvant Chemotherapy Setting: A Retrospective Analysis.

Background: The present study was conducted to evaluate the clinical, pathological response, and prognosis characteristics of human epidermal growth factor receptor 2 (HER2)-low breast cancer in the neoadjuvant chemotherapy setting.

Methods: Patients with HER2-negative breast cancer who received neoadjuvant chemotherapy from January 2017 to December 2019 were retrospectively analyzed. HER2-negative breast cancer was divided into two groups: HER2-zero (defined as immunohistochemistry [IHC] 0) and HER2-low (defined as IHC 1+, or IHC 2+ and fluorescence in-situ hybridization-negative.

Electronic and Magnetic Properties of Defected Monolayer WSe with Vacancies.

By adopting the first-principle methods based on the density functional theory, we studied the structural, electronic, and magnetic properties of defected monolayer WSe with vacancies and the influences of external strain on the defected configurations. Our calculations show that the two W atom vacancies (V) and one W atom and its nearby three pairs of Se atom vacancies (V) both induce magnetism into monolayer WSe with magnetic moments of 2 and 6 μ, respectively. The magnetic moments are mainly contributed by the atoms around the vacancies.

Pmma-XO (X = C, Si, Ge) monolayer as promising anchoring materials for lithium-sulfur battery: a first-principles study.

Lithium-sulfur (Li-S) batteries hold great promise for the next-generation lithium-ion energy storage devices. A key issue in the Li-S batteries is, however, the dissolving and migrating of the soluble polysulfides during the charge and discharge processes and introducing anchoring materials (AM) in the batteries effectively prevent the problem and improve the cycling stability of the Li-S batteries. Herein, Pmma-XO (X = C, Si, Ge, Sn) monolayers are introduced as AM to confine the lithium polysulfides and their anchoring properties are studied with the density functional theory methods.

3-Fold-Periodic Size-Dependence in Electronic Properties of Monolayer-TMDC Nanotriangles.

Stable nanotriangles of monolayer transitional metal dichalcogenides (referred herein as MS mNTs) grown via ordinary deposition conditions, where M = Mo or W, exhibit a peculiar 3-fold periodic size-dependence in electronic and chemical properties. For " k" being the number of M atoms per edge, mNTs are (a) intrinsic-semiconducting when k = 3 i + 1, such as k = 7, 10, 13, 16; (b) metallic-like with no bandgap when k = 3 i; (c) n semiconducting when k = 3 i - 1. Besides changes in electronic properties, the catalytic properties for hydrogen evolution reaction also switch from active for k = 3 i and 3 i - 1 to inactive for k = 3 i + 1.

Expression and significance of DDX43 in lung adenocarcinoma.

This paper aims to determine the expression and clinical significance of DDX43 in lung adenocarcinoma. Expression of DDX43 gene and protein of lung adenocarcinoma tissue and para-carcinoma tissues was observed in 27 cases by RT-PCR and immunohistochemistry. These patients were diagnosed as lung adenocarcinoma in the Huaihe Hospital of Henan University from February 2015 to December 2015.

MicroRNA-146a affects the chemotherapeutic sensitivity and prognosis of advanced gastric cancer through the regulation of LIN52.

The present study aimed to evaluate the correlation between the expression of microRNA-146a (miR-146a) and its target gene, LIN52, in advanced gastric cancer, and determine their potential effects on chemotherapeutic sensitivity and prognosis. Total RNA was extracted from 93 tissue samples of advanced gastric cancer and corresponding adjacent non-tumor tissues to quantify the relative expression levels of miR-146a using reverse transcription-quantitative polymerase chain reaction analysis. The expression of LIN52 was detected in tumors and normal tissues using immunohistochemical analysis.

Nanopolygons of Monolayer MS: Best Morphology and Size for HER Catalysis.

With first-principles calculations, we find a new strategy for developing high-performance catalysts for hydrogen evolution reaction (HER) via controlling the morphology and size of nanopolygons of monolayer transition-metal dichalcogenides (npm-MS, with M = Mo, W, or V). Particularly, through devising a quantitative method to measure HER-active sites per unit mass and using such HER site density to comparatively gauge npm-MS performance, we identify three keys in making npm-MS with optimal HER performance: (a) npm-MS should be triangular with each edge being M-terminated and each edge-M atom passivated by one S atom; (b) each edge of npm-MoS and WS should have 5-6 metal atoms as HER site density drops below/above these sizes optimal both for HER and practical npm growth; and (c) npm-VS is immune to this overly fastidious size dependence. Known experimental data on npm-MoS indeed support the plausibility of practicing these design rules.

Clinical significance of HOTAIR expression in colon cancer.

Aim: To detect the expression of the long noncoding RNA HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer.

Methods: Total RNA was extracted from 80 colon cancer tissues and matched tumor-adjacent normal colon tissues and reverse transcribed. Quantitative polymerase chain reaction was used to detect the expression of HOTAIR.

[Effects of hydroxycamptothecin and teniposide on proliferation and apoptosis of gastric cancer cell line BGC-823].

Background & Objective: Some studies have showed that topoisomerase (Topo)I and II inhibitors have synergistic effects in tumor therapy, but the combinations have seldom been used in gastric cancer. This study was to investigate the effects of Topo I inhibitor hydroxycamptothecin (HCPT) and Topo II inhibitor teniposide (VM-26) on the proliferation and apoptosis of gastric cancer cell line BGC-823.

Methods: MTT assay was used to examine the inhibitory effects of VM-26 and HCPT, used alone or in combination, on the proliferation of BGC-823 cells.