CD305 participates in abnormal activation of memory CD4 T cells in patients with RA and attenuates collagen-induced arthritis.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly affects the joints. Studies have shown that memory CD4 T cells play an important role in the pathogenesis of RA. This study investigated the expression and function of CD305 on human memory CD4 T cells and the effects of CD305 activating antibody on collagen-induced arthritis.

Genome-Wide Identification and Expression Analysis of the Starch Synthase Gene Family in Sweet Potato and Two of Its Closely Related Species.

The starch synthase (SS) plays important roles in regulating plant growth and development and responding to adversity stresses. Although the family has been studied in many crops, it has not been fully identified in sweet potato and its two related species. In the present study, eight were identified from (), (), and (), respectively.

Coal-Rock Dynamic Disaster Prevention Mechanism Based on the Dual Loads of Dynamic Barrier and Static Pressure Relief by Hydraulic Slotting.

According to the characteristics of coal-rock dynamic disasters and hydraulic slotting, the mechanism of dynamic load barrier and static load pressure relief in hydraulic slotting is proposed. The stress distribution in a coal mining face and the slotted area of a section coal pillar is analyzed by numerical simulation. The results show that the slot formed by hydraulic slotting can effectively alleviate the stress concentration and transfer the high-stress area to a deeper coal seam.

Identification and functional characterization of the SUMO system in sweet potato under salt and drought stress.

Sumoylation is a crucial post-translation modification (PTM) that is the covalent attachment of SUMO molecules to the substrate catalyzed by enzyme cascade. Sumoylation is essential in almost every physiological process of plants, particularly in response to abiotic stress. However, little is known about sumoylation in sweet potato (Ipomoea batatas), the world's seventh most important food crop.

One-pot synthesis of phosphorylnaphth[2,1-]oxazoles and products as P,N-ligands in C-N and C-C formation.

Phosphanylnaphtho[2,1-]oxazoles were synthesized successfully through one-pot phosphonation of naphthoquinone with diaryl(alkyl)phosphine oxides and Cu-catalyzed oxidative condensation with imines, followed by methylation and reduction. Upon applying 4-phosphanylnaphtho[2,1-]oxazole as a P,N-chelating ligand, Pd-catalyzed C-N formation of amines or nitrobenzene as well as Ni-catalyzed C-C formation and the synthesis of quinoline proceeded successfully. The reaction was facilely scaled up to give -benzylaniline 15a in a gram scale synthesis.

Applicability and implementation of the collagen-induced arthritis mouse model, including protocols (Review).

Animal models of rheumatoid arthritis (RA) are essential for studying the pathogenesis of RA and determining the efficacy of anti-RA drugs. During the past decades, numerous rodent models of arthritis have been evaluated as potential models and the modeling methods are relatively well-developed. Among these models, the collagen-induced arthritis (CIA) mouse model is the first choice and the most widely used because it may be generated rapidly and inexpensively and is relatively similar in pathogenesis to human RA.

[Progress on relationship between IL-23/IL-17 axis and inflammatory bowel disease].

Chronic inflammatory damage of intestinal mucosa is an important characteristic of inflammatory bowel disease (IBD). Studies have shown that the interleukin 23 (IL-23)/IL-17 axis is involved in intestinal mucosal inflammatory injury and plays a crucial role in the development and prognosis of IBD. IL-23 is one of the upstream molecules of IL-17, which can promote Th17 cell activation, proliferation and the secretion of inflammatory cytokines.

Role and mechanism of LAIR-1 in the development of autoimmune diseases, tumors, and malaria: A review.

The levels of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), a type I transmembrane glycoprotein broadly expressed on the majority of hematopoietic cells, such as T/B cells and natural killer cells, vary significantly during cell differentiation and activation. Previous studies focused mainly on the role of LAIR-1 in physiology and some pathological conditions, including autoimmune diseases. It has been shown that LAIR-1 mediates immune suppression, further resulting in uncontrolled inflammation.

A Potential Mechanism of Temozolomide Resistance in Glioma-Ferroptosis.

Temozolomide (TMZ) is the first-line chemotherapy drug that has been used to treat glioma for over a decade, but the benefits are limited by half of the treated patients who acquired resistance. Studies have shown that glioma TMZ resistance is a complex process with multiple factors, which has not been fully elucidated. Ferroptosis, which is a new type of cell death discovered in recent years, has been reported to play an important role in tumor drug resistance.

The Emerging Role of Myeloid-Derived Suppressor Cells in the Glioma Immune Suppressive Microenvironment.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid progenitor and precursor cells at different stages of differentiation, which play an important role in tumor immunosuppression. Glioma is the most common and deadliest primary malignant tumor of the brain, and ample evidence supports key contributions of MDSCs to the immunosuppressive tumor microenvironment, which is a key factor stimulating glioma progression. In this review, we summarize the source and characterization of MDSCs, discuss their immunosuppressive functions, and current approaches that target MDSCs for tumor control.

Recent Advances of Sulfonylation Reactions in Water.

Background: The sulfonyl groups are general structural moieties present in agrochemicals, pharmaceuticals, and natural products. Recently, many efforts have been focused on developing efficient procedures for preparation of organic sulfones.

Materials And Methods: Water, a proton source, is considered one of the most ideal and promising solvents in organic synthesis for its easy availability, low cost, nontoxic and nonflammable characteristics.

Direct cyanation, hydrocyanation, dicyanation and cyanofunctionalization of alkynes.

In this review, direct cyanation, hydrocyanation, dicyanation, cyanofunctionalization and other cyanation reactions of alkynes were highlighted. Firstly, the use of nitriles and development of cyanation was simply introduced. After presenting the natural properties of alkynes, cyanation reactions of alkynes were classified and introduced in detail.

The mechanism of propofol in cancer development: An updated review.

Cancer is a key cause of death worldwide. Despite the development of radiotherapy, chemotherapy and even immunotherapy, surgery remains the standard treatment for cancer patients. Recently, many studies have shown that propofol, a commonly used anesthetic drug, can affect the prognosis of cancer.

Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147.

Shikonin, a traditional Chinese medicine, has been identified as being capable of inducing apoptosis in various tumors, including glioma, and is thus considered to be a promising therapeutic agent for tumor therapy. However, little is known about the molecular mechanism of shikonin in glioma. The present study investigated the influence of shikonin on the proliferation and apoptosis of glioma cells U251 and U87MG and explored the potential molecular mechanisms.

Long non‑coding RNA UCA1 promotes papillary thyroid cancer cell proliferation via miR‑204‑mediated BRD4 activation.

Long non‑coding RNA (lncRNA) urothelial carcinoma‑associated 1 (UCA1) has been used in tumor development and progression in many types of cancer. However, the function and mechanism underlying the action of UCA1 in papillary thyroid cancer (PTC) remains unclear. Therefore, these topics were investigated in the present study by in vitro and in vivo experiments.

Disrupted in schizophrenia 1 (DISC1) inhibits glioblastoma development by regulating mitochondria dynamics.

Glioblastoma(GBM) is one of the most common and aggressive malignant primary tumors of the central nervous system and mitochondria have been proposed to participate in GBM tumorigenesis. Previous studies have identified a potential role of Disrupted in Schizophrenia 1 (DISC1), a multi-compartmentalized protein, in mitochondria. But whether DISC1 could regulate GBM tumorigenesis via mitochondria is still unknown.

CD147 is increased in HCC cells under starvation and reduces cell death through upregulating p-mTOR in vitro.

Transarterial chemoembolization (TACE) is the standard of care for treatment of intermediate hepatocellular carcinoma (HCC), however, key molecules involved in HCC cell survival and tumor metastasis post-TACE remain unclear. CD147 is a member of the immunoglobulin superfamily that is overexpressed on the surface of HCC cells and is associated with malignant potential and poor prognosis in HCC patients. In this study, using an Earle's Balanced Salt Solution medium culture model that mimics nutrient deprivation induced by TACE, we investigated the regulation of CD147 expression on HCC cells under starvation conditions and its functional effects on HCC cell death.

Chromium isotopic fractionation during Cr(VI) reduction by Bacillus sp. under aerobic conditions.

This study investigated the fractionation of chromium isotopes during chromium reduction by Bacillus sp. under aerobic condition, variable carbon source (glucose) concentration (0, 0.1, 1, 2.

Berberine sensitizes rapamycin‑mediated human hepatoma cell death in vitro.

Rapamycin is clinically used as an immunosuppressant. Increasing evidence suggests that rapamycin has an important inhibitory role in the development and progression of different types of cancer and that it is a promising candidate for cancer chemotherapy. Berberine is an isoquinoline alkaloid isolated from medicinal plant species, which has been used in traditional Chinese medicine with no significant side effects.

The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis.

The association between the rs498872 single nucleotide polymorphism (SNP) and glioma risk has been studied, but these studies have yielded conflicting results. In order to explore this association, we performed a meta-analysis. A comprehensive literature search was performed using PubMed and EMBASE database, with the last search up to August 23, 2013.

Ultrafast all-optical graphene modulator.

Graphene is an optical material of unusual characteristics because of its linearly dispersive conduction and valence bands and the strong interband transitions. It allows broadband light-matter interactions with ultrafast responses and can be readily pasted to surfaces of functional structures for photonic and optoelectronic applications. Recently, graphene-based optical modulators have been demonstrated with electrical tuning of the Fermi level of graphene.

General approach to splicing optical microfibers via polymer nanowires.

We demonstrate a general approach to splicing microfibers via polymer nanowires. Chloroform dissolved polystyrene nanowires are used to splice silica, tellurite glass, and semiconductor microfibers or nanowires, with splicing loss down to 0.51 dB.

[Effect of ginsenoside Rg3 on Pim-3 and Bad proteins in human pancreatic cancer cell line PANC-1].

Background And Objective: Ginsenoside Rg3 is a traditional Chinese medicine monomer which possesses anticancer effects. This study was to investigate the effects of ginsenoside Rg3 on Pim-3 and phosphorylated Bad (pBad) proteins, pBad (Ser112) and pBad (Ser136) in human pancreatic cancer cell line PANC-1.

Methods: PANC-1 cells were exposed to 10, 20, 40 and 80 micromol/L ginsenoside Rg3 for 24 h.

Endface reflectivities of optical nanowires.

Endface reflectivities (ERs) of optical nanowires are investigated using three-dimensional finite-difference time-domain simulations. Typical ERs of both free-standing and substrate-supported silica, tellurite, PMMA and semiconductor nanowires or nanofibers are obtained. Unlike in conventional waveguides such as optical fibers, ERs of nanowires are usually considerably lower when operated in single mode.

All-fiber Fabry-Perot resonators based on microfiber Sagnac loop mirrors.

We demonstrate all fiber Fabry-Perot resonators (F-P resonators) based on Sagnac loop mirrors assembled with tellurite microfibers. As-assembled F-P resonators, with dimensions of hundreds of micrometers, show clear resonant responses with typical quality factor of about 5700, free spectral range of about 1 nm, and a maximum extinction ratio of 18 dB. The reflectivity of the loop mirror and the effective cavity length of the F-P resonator can be tuned by micromanipulation under an optical microscope.