Publications by authors named "Zhidu Song"
Article Synopsis
- Exosomes are small vesicles released by cells that can activate the immune system, making them promising tools in cancer immunotherapy due to their ability to transfer molecules and trigger immune responses.
- They originate from immune and tumor cells, showcasing unique compositions that can influence immune functions and overall cancer progression.
- Understanding how exosomes work in immunotherapy is crucial, as they hold potential as cancer vaccines and targeted drug carriers, offering new strategies to enhance anti-cancer immunity.
Article Synopsis
- CRISPR/Cas systems have great potential to transform cancer treatment, especially through the use of extracellular vesicles (EVs) and viral vectors for effective delivery.
- Engineered EVs, such as exosomes, can successfully transport CRISPR components to tumor cells, inhibiting growth and improving chemotherapy response, but face challenges like off-target effects and immune reactions.
- Viral vectors like adeno-associated viruses (AAVs) and adenoviral vectors (AdVs) are effective delivery methods, each with unique advantages and hurdles, and future efforts will focus on optimizing these systems for safer, more targeted cancer therapies.
Article Synopsis
- Advances in stem cell technology, particularly with multipotent mesenchymal stem cells (MSCs), are opening up new treatment options for a variety of diseases and disorders.
- MSCs can self-renew and differentiate into various cell types, showing potential benefits in areas like tissue regeneration, immune response, and wound healing.
- The review highlights the clinical applications of MSCs sourced from umbilical cord, bone marrow, and adipose tissue, discussing their effectiveness in treating issues such as pulmonary, neurological, and cardiovascular diseases.
MicroRNA‑506 regulates apoptosis in retinoblastoma cells by targeting sirtuin 1.
Cancer Manag Res
September 2019
Background: MicroRNAs have been reported to participate in the initiation and progression of retinoblastoma (RB), most common malignancy in children. The refractory mechanisms of chemoresistance and the toxicity of chemotherapies hindered the treatment especially on young children. Novel RB therapies are urgently required.
View Article and Find Full Text PDFRetinoblastoma (RB) is the most common type of malignant intraocular cancer in teenagers. One of the proteins abnormally expressed during oncogenesis of RB is sonic hedgehog (SHH), which possesses the capability to selectively activate transcription factors of different genes. However, the detailed function of SHH in RB remains unknown.
View Article and Find Full Text PDFPurpose: A meta-analysis was conducted to assess the effects of the aldose reductase (ALR) C-106T polymorphism on the risk for development of diabetic retinopathy (DR) in the Chinese population.
Materials And Methods: Relevant studies were identified using PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) through 21 March 2015. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations.
Neural injury is associated with the development of diabetic retinopathy. Müller cells provide structural and metabolic support for retinal neurons. High glucose concentrations are known to induce Müller cell activity.
View Article and Find Full Text PDF