Publications by authors named "Zhidong Zhou"

Background: A systematic evaluation and network meta-analysis (NMA) using randomized controlled trials (RCTs) was conducted to investigate the effects of different exercise intensities and dosages on the mental health of college students.

Methods: A systematic search of eight electronic databases of RCTs involving mental health exercise interventions for college students was conducted, which included data from the inception of the databases through July 2024. Two independent reviewers assessed the quality of the literature.

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Aim: Excessive weight gain in childhood has been associated with poor health outcomes throughout life span and has a strong tracking effect in adulthood. This study aimed to investigate trends in the prevalence of overweight, obesity and severe obesity among Chinese children from 2010 to 2020.

Methods: A total of 42 982 Chinese children aged 2-18 years were included in the Chinese Family Panel Studies carried out every 2 years from 2010 to 2020.

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Objectives: To investigate the spatiotemporal variations in body mass index among Han adolescents aged 18 years across 27 provinces of China from 1985 to 2019.

Study Design: Cross-sectional epidemiological study.

Methods: A total of 141,406 adolescents aged 18 years were included from eight Chinese National Surveillance on Students' Constitution and Health from 1985 to 2019.

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Article Synopsis
  • The NOTCH2NLC gene is linked to several neurological disorders through expansions of GGC repeats in its 5' untranslated region, which can lead to conditions like Parkinson's, dementia, and tremors.
  • The study used cellular models and CRISPR-Cas9 engineered mice with specific GGC repeat variations to investigate the effects of these repeats, particularly focusing on those with serine insertions.
  • Results showed that a specific intermediate repeat with serine insertion caused mitochondrial dysfunction and neurotoxicity, leading to PD-like symptoms in mice, including neuronal loss and behavioral impairments.
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Cellular nanoparticles (CNPs), which refer to nanoparticles coated with natural cell membranes, are promising for neutralizing pathological agents. Here, we use CNPs as a medical countermeasure against the infection of SARS-CoV-2 variants in an animal model. CNPs comprise polymeric cores coated with the plasma membranes of human macrophages.

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  • HERC2, a type of E3 ubiquitin ligase, is found to be highly active in hypertrophic hearts and promotes cardiac hypertrophy by increasing the expression of Lin28a, an RNA-binding protein involved in heart growth.
  • Knockdown of HERC2 alleviates hypertrophy caused by angiotensin II (Ang II), while its overexpression worsens the condition.
  • The study suggests that HERC2 influences Lin28a levels through the degradation of MeCP2, a protein that normally suppresses Lin28a, highlighting the potential of targeting this HERC2/MeCP2/Lin28a pathway to treat heart failure.
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Objectives: This meta-analysis and systematic review examined the effects of an exercise intervention on alcohol dependence and physical and mental states in patients with alcohol use disorder (AUD).

Data Sources: PubMed, Web of Science, Cochrane Library, EBSCO, and Embase.

Study Inclusion And Exclusion Criteria: Randomized controlled trials published in English from the inception of the database until June 30, 2024, were included.

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  • The study investigated the causes of acute pneumonia in puppies in China by analyzing bronchoalveolar lavage (BAL) fluid to isolate and identify pathogens, as well as assess their antibiotic resistance and virulence genes.
  • Four extraintestinal pathogenic (ExPEC) strains were identified, showing resistance to certain antibiotics like cephalosporins and tetracyclines, but sensitivity to others such as aminoglycosides and carbapenems.
  • The research also found that the ExPEC strains were not present in the kennel’s drinking water, dismissing water contamination as a factor in the outbreak, and provided insights into potential treatments and mechanisms of the pathogens.
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  • Caffeine consumption, primarily from coffee and tea, is substantial worldwide, yet caffeine dependence remains an under-recognized issue.
  • This systematic review analyzed genetic factors affecting caffeine metabolism and reward to see how they relate to caffeine intake, utilizing case-control studies of habitual drinkers.
  • Results showed that specific genes linked to caffeine metabolism and reward were associated with a 3% to 32% variation in daily caffeine consumption, indicating potential for identifying individuals at risk for caffeine dependence, especially in certain ethnic groups.
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In recent decades, with the intensification of human activities, atmospheric nitrogen (N) deposition has been increasing. N deposition affects carbon (C) cycling in terrestrial ecosystems, especially in fragile karst ecosystems. Karst ecosystems are considered to be an important C pool.

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Currently, the actual mechanical properties of carbon fibers (CF) differ significantly from the theoretical values. This is primarily attributed to significant limitations imposed by structural defects, greatly hindering the widespread application of CF. To solve this problem, we used in situ growth of zeolitic imidazolate framework-8 (ZIF-8) and γ rays to modulate the core-shell of CF in this study.

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Background: To evaluate the effects of different interventions on adolescent internet addiction, a meta-analysis and network meta-analysis were performed to determine the possible intervention effects of these interventions.

Methods: Computer searches of the China National Knowledge Network, Wanfang, VIP, EMBASE, PubMed, Web of Science, EBSCO, and Cochrane Library databases were performed. The relevant randomized controlled trials were designed to assess the effects of interventions on adolescent internet addiction.

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Objectives: The aim of this study was to analyze the temporal trends in cardiorespiratory fitness (CRF) and body mass index (BMI) among children and adolescents from 1985 to 2019.

Methods: A total of 1 840 212 children and adolescents aged 7-18 years (921 223 boys) were tested for CRF from 1985 to 2019. CRF was tested by 50-m × 8 shuttle run for boys and girls aged 7-12 years, 1000-m run for boys aged 13-18 years, and 800-m run for girls aged 13-18 years.

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Effectively neutralizing inflammatory cytokines is crucial for managing a variety of inflammatory disorders. Current techniques that target only a subset of cytokines often fall short due to the intricate nature of redundant and compensatory cytokine networks. A promising solution to this challenge is using cell membrane-coated nanoparticles (CNPs).

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The impact of microplastics and their additives on soil nutrient cycling, particularly through microbial mechanisms, remains underexplored. This study investigated the effects of polyethylene microplastics, polyethylene resin, and plastic additives on soil nitrogen content, physicochemical properties, nitrogen cycling functional genes, microbial composition, and nitrogen transformation rates. Results showed that all amendments increased total nitrogen but decreased dissolved total nitrogen.

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Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with pathological features of β-amyloid (Aβ) and hyperphosphorylated tau protein accumulation in the brain, often accompanied by cognitive decline. So far, our understanding of the extent and role of adaptive immune responses in AD has been quite limited. T cells, as essential members of the adaptive immune system, exhibit quantitative and functional abnormalities in the brains of AD patients.

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Objectives: To examine the secular trends and urban-rural disparities in height of Chinese adolescents aged 18 years from 1985 to 2019.

Methods: Data were extracted from the Chinese National Surveys on Students' Constitution and Health from 1985 to 2019, and the heights of a total of 76 554 boys and 75 908 girls aged 18 years were measured. The Mann-Kendall trend test was used to analyze the secular trends in height.

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In this paper, the barrier mechanism of silico-alkaline sol-modified bentonite as cutoff wall materials for lead ions in lead‑zinc tailings ponds was investigated. Mechanical property tests, adsorption capacity tests, and permeability tests were conducted to assess the performance of the materials. The results indicated that the addition of silico-alkaline sol at a proportion of 20% by weight of bentonite improved the mechanical strength, anti-seepage ability, and adsorption capacity of the materials towards lead ions.

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Currently, the mechanical performance of carbon fibers (CFs) has yet to fully realize its theoretical potential. This is predominantly attributed to the significant constraints posed by surface defects, greatly impeding the widespread application of carbon fibers. In order to address this issue, we employed a sonochemical-induced approach in this study to achieve in situ growth of nanoscale zeolitic imidazolate framework-8 (ZIF-8) at the surface defects of carbon fibers.

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Botulinum toxin (BoNT) is a potent neurotoxin that poses a significant threat as a biowarfare weapon and a potential bioterrorist tool. Currently, there is a lack of effective countermeasures to combat BoNT intoxication in the event of a biological attack. Here, we report on a novel solution by combining cell metabolic engineering with cell membrane coating nanotechnology, resulting in the development of glycan-modified cellular nanosponges that serve as a biomimetic and broad-spectrum BoNT detoxification strategy.

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