Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma.

This study showcases a comprehensive treatment protocol for high-risk hepatocellular carcinoma (HCC) patients, focusing on the combined use of Y-90 transarterial radioembolization (TARE) and Programmed Cell Death-1 (PD-1) inhibitors as neoadjuvant therapy. Highlighted through a case report, it offers a step-by-step reference for similar therapeutic interventions. A retrospective analysis was conducted on a patient who underwent hepatectomy following Y-90 TARE and PD-1 inhibitor treatment.

Effect of Surface Dispersion of Fe Nanoparticles on the Room-Temperature Flash Sintering Behavior of 3YSZ.

Arc floating in surface flashover can be controlled by reducing the interfacial charge-transfer resistance of ceramics. However, thus far, only a few studies have been conducted on methods of treating ceramic surfaces directly to reduce the interfacial charge-transfer resistance. Herein, we explore the flash sintering behavior of a ceramic surface (3 mol% yttria-stabilized zirconia (3YSZ)) onto which loose metal (iron) powder was spread prior to flash sintering at room temperature (25 °C).

Reactive Flash Sintering of High-Entropy Oxide (Mg, Co, Ni, Cu, Zn)LiO at Room Temperature.

(Mg, Co, Ni, Cu, Zn)LiO is a type of high-entropy oxide that has high ionic conductivity at room temperature and is used as a solid electrolyte. (Mg, Co, Ni, Cu, Zn)LiO was successfully synthesized from precursor powder by applying reactive flash sintering for less than 4 min at room temperature (25 °C). AC and DC electric fields were independently applied to sinter ceramic samples; consequently, AC and DC electric field application resulted in relative densities that exceeded 90% and 80%, respectively.

Application of 3D Hepatic Plate-Like Liver Model for Statin-Induced Hepatotoxicity Evaluation.

Drug-induced liver injury is one of the main reasons of withdrawals of drugs in postmarketing stages. However, an experimental model(s) which can accurately recapitulates liver functions and reflects the level of drug hepatotoxicity is lack. In this study, we assessed drug hepatotoxicity using a novel three-dimensional hepatic plate-like hydrogel fiber (3D-P) co-culture system.

Ethanol-Induced Flash Sintering of ZnO Ceramics at Room Temperature.

Ceramic flash sintering with a strong electric field at room temperature is the most attractive method. This paper presents the flash sintering of ZnO ceramics at room temperature by the application of a 3-kV/cm electric field after a dropwise addition of ethanol. This method is simple and easy to control.

3D Culture System for Liver Tissue Mimicking Hepatic Plates for Improvement of Human Hepatocyte (C3A) Function and Polarity.

3D hepatocyte culture constitutes a core aspect of liver tissue engineering. However, conventional 3D cultures are unable to maintain hepatocyte polarity, functional phenotype, or viability. Here, we employed microfluidic chip technology combined with natural alginate hydrogels to construct 3D liver tissues mimicking hepatic plates.

Analysis of Pollution in High Voltage Insulators via Laser-Induced Breakdown Spectroscopy.

Surface pollution deposition in a high voltage surface can reduce the surface flashover voltage, which is considered to be a serious accident in the transmission of electric power for the high conductivity of pollution in wet weather, such as rain or fog. Accordingly, a rapid and accurate online pollution detection method is of great importance for monitoring the safe status of transmission lines. Usually, to detect the equivalent salt deposit density (ESDD) and non-soluble deposit density (NSDD), the pollution should be collected when power cut off and bring back to lab, time-consuming, low accuracy and unable to meet the online detection.

Study on the Anticondensation Characteristics of Liquid Silicone Rubber Temperature-Control Coatings.

Metal cabinets such as switch cabinets and ring network cabinets have the advantages of small footprints and good protection for equipment and offer neat and orderly protection. They are widely used in power systems. In a hot and humid environment, condensation can easily cause equipment to age and even cause insulation failure.

A Quick Classifying Method for Tracking and Erosion Resistance of HTV Silicone Rubber Material via Laser-Induced Breakdown Spectroscopy.

Silicone rubber material is widely used in high-voltage external insulation systems due to its excellent hydrophobicity and hydrophobicity transfer performance. However, silicone rubber is a polymeric material with a poor ability to resist electrical tracking and erosion; therefore, some fillers must be added to the material for performance enhancement. The inclined plane test is a standard method used for evaluating the tracking and erosion resistance by subjecting the materials to a combination of voltage stress and contaminate droplets to produce failure.

Nonlinear Electrical Properties and Field Dependency of BST and Nano-ZnO-Doped Silicone Rubber Composites.

Recently, composite materials with nonlinear dielectric or resistive properties performed well in electric field homogenization and space charge suppression in a high voltage transmission and distribution system. For the purpose of obtaining insulation materials with desirable dielectric and electrical resistance properties, we investigated several fillers with nonlinear electrical properties doped in silicon rubber composites, and their dependency on the temperature and field. The samples of silicone rubber composites with different components were prepared using barium strontium titanate (BST) and zinc oxide (ZnO) as the filler, and high temperature vulcanized silicone rubber (SiR) as the matrix.

Novel sericin-based hepatocyte serum-free medium and sericin's effect on hepatocyte transcriptome.

Aim: To develop a novel hepatocyte serum-free medium based on sericin, and to explore the effect of sericin on the hepatocyte transcriptome.

Methods: A controlled trial comparing novel serum-free medium and other media: C3A cells were cultured in our novel serum-free medium, HepatoZYME, complete medium (DMEM/F12 with 100 mL/L FBS), and DMEM/F12, and then cell attachment, proliferation, and function as well as the biocompatibility of the media were assessed. A comparative study of serum-free media with or without 2 mg/mL sericin: the effect of sericin on C3A growth was assessed by cell viability and proliferation, the effect of sericin on C3A cell cycle distribution was determined by flow cytometry, and the effect of sericin on the C3A transcriptome was assessed by gene-chip array and RT-qPCR.

Metal Contamination Distribution Detection in High-Voltage Transmission Line Insulators by Laser-induced Breakdown Spectroscopy (LIBS).

The fast detection of classical contaminants and their distribution on high-voltage transmission line insulators is essential for ensuring the safe operation of the power grid. The analysis of existing insulator contamination has traditionally relied on taking samples during a power cut, taking the samples back to the lab and then testing them with elemental analysis equipment, especially for sugars, bird droppings, and heavy metal particulates, which cannot be analysed by the equivalent salt deposit density (ESDD) or non-soluble deposit density (NSDD) methods. In this study, a novel method called laser-induced breakdown spectroscopy (LIBS) offering the advantages of no sample preparation, being nearly nondestructive and having a fast speed was applied for the analysis of metal contamination.

Fabrication of agarose concave petridish for 3D-culture microarray method for spheroids formation of hepatic cells.

Liver is one of the most important organ in the body. But there are many limitations about liver transplantation for liver failure. It is quite important to develop the xenogeneic biological liver for providing an alternation to transplantation or liver regeneration.

Immobilization of native type I collagen on polypropylene fabrics as a substrate for HepG2 cell culture.

Background/aims The critical part of a bio-artificial liver device is establishment of a bioreactor filled with liver cells. However, it is still unclear how to maintain benign cell function while achieving the sufficient cell quantity. In the current study, we aim to establish a novel carrier for the culture of HepG2 cells, a liver cell line, by modifying polypropylene nonwoven fabrics with native type I collagen.

[Spectral analysis of polyphenol oxidase (PPO) and lipoxygenase (LOX) treated by pulsed electric field].

Inactivation effect of pulsed electric field (PEF) on polyphenol oxidase (PPO) and lipoxygenase (LOX) was investigated using a laboratory PEF system with a coaxial treatment chamber. Circular dichroism (CD) and fluorescence analysis were used to study the conformation change of the protein. The experimental results show that PPO and LOX can be effectively inactivated by the PEF treatment.