inhibition suppresses the growth of lung cancer cells through activation of -mediated ferroptosis.

Background: Ferroptosis is a type of cell death driven by iron accumulation and lipid peroxidation, which is involved in the pathogenesis of various tumors. Small ubiquitin-like modifier (SUMO)-specific protease 1 () is a critical SUMO-specific protease, which controls multiple cellular signaling processes. However, the roles and mechanisms of -mediated protein SUMOylation in the regulation of cell death and ferroptosis remain unexplored.

The contribution of Pir protein family to yeast cell surface display.

Proteins with internal repeats (Pir) in the Baker's yeast are located on the cell wall and include four highly homologous members. Recently, Pir proteins have become increasingly used as anchor proteins in yeast cell surface display systems. These display systems are classified into three types: N-terminal fusion, C-terminal fusion, and inserted fusion.