Prenylated chromones and flavonoids isolated from the roots of Flemingia macrophylla and their anti-lung cancer activity.

Background: The successful launch of icaritin, a therapeutic drug for liver cancer derived from Epimedium brevicornu, has provided new impetus for the development of prenylated flavonoids in the field of oncology. Flemingia macrophylla is reported to contain characteristic prenylated flavonoids which can regulate the p53 protein. We aimed to isolate these constituents and conduct activity evaluation, structure-activity relationship, and mechanism studies to provide candidate compounds for antitumor drug development.

The expression of lncRNA XIST in hepatocellular carcinoma cells and its effect on biological function.

Purpose: Hepatocellular carcinoma (HCC) is one of the common cancers, but its relationship with long non-coding (lnc)RNA XIST and microRNA (miR)-488 is still under investigation. Therefore, this study aimed to explore the correlation between miR-488 and XIST in HCC.

Methods: qRT-PCR was employed to quantify the lncRNA XIST and miR-488 in HCC tissues and cells, and miR-488 mimcs and lncRNA siRNA vectors were constructed for analysis of the roles of miR-488 and lncRNA XIST in HCC cells.

Auxin and Its Interaction With Ethylene Control Adventitious Root Formation and Development in Apple Rootstock.

Adventitious root (AR) formation is indispensable for vegetative asexual propagation. Indole-3-butyric acid (IBA) functioned indirectly as precursor of IAA in regulating AR formation. Ethylene affects auxin synthesis, transport, and/or signaling processes.