Publications by authors named "Zhichun Zhu"
Coenzyme Q (CoQ) is the most consumed dietary supplement and mainly biosynthesized by aerobic fermentation of Rhodobacter sphaeroides (R. sphaeroides). Oxygen supply was identified as a bottleneck for improving CoQ yield in R.
View Article and Find Full Text PDFPhosphate limitation increases coenzyme Q production in industrial HY01.
Synth Syst Biotechnol
December 2019
Article Synopsis
- Coenzyme Q (CoQ) is crucial for the respiratory chain and acts as a potent antioxidant, potentially preventing cardiovascular disease.
- In the study, phosphate-limited conditions significantly enhanced CoQ production in a specific strain (HY01), leading to a maximum yield of 1.95 g/L in a bioreactor.
- The results suggest that limiting phosphate can alter cell metabolism and improve CoQ biosynthesis by affecting energy metabolism and redox balance, as shown through transcriptome analysis.