Caprine endometrial stromal cells modulate the effects of steroid hormones on cytokine secretion by endometrial epithelial cells in vitro.

The main purpose of this study was to examine the effects of 17β-estradiol (E(2)) and progesterone (P(4)) on cytokine secretion by caprine endometrial epithelial cells (EEC) in vitro. Epithelial cells grown alone or in co-culture with stromal cells (ESC) were treated with E(2) or P(4), or both. Homogeneity of the endometrial cell populations was ascertained immunocytochemically.