In-situ direct shear test and numerical comparative research on mudstone gravel slope reinforced by polymer grouting.

This study investigates the shear strength characteristics of mudstone gravel slope following polymer grouting reinforcement through in-situ direct shear test. A corresponding numerical model was developed to analyze stress distribution. The findings indicate that shear stress initially increases and then stabilizes with horizontal displacement during the pre-grouting shear test.

Dual activation of soybean resistance against Phytophthora sojae by pectin lyase and degraded pectin oligosaccharides.

Phytophthora pathogens secrete numerous apoplastic effectors to manipulate host immunity. Herein, we identified a polysaccharide lyase 1 protein, PsPL1, which acts as an essential virulence factor of P. sojae infection in soybean.

Boosting Carrier Transport in Quasi-2D/3D Perovskite Heterojunction for High-Performance Perovskite/Organic Tandems.

Wide-bandgap (WBG) perovskites are continuously in the limelight owing to their applicability in tandem solar cells. The main bottlenecks of WBG perovskites are interfacial non-radiative recombination and carrier transport loss caused by interfacial defects and large energy-level offsets, which induce additional energy losses when WBG perovskites are stacked with organic solar cells in series because of unbalanced carrier recombination in interconnecting layer (ICL). To solve these issues, 1,3-propanediammonium iodide (PDADI) is incorporated to form Dion-Jacobson -phase quasi-2D perovskites with mixed high-n-values in WBG perovskites.

A New Scene Sensing Model Based on Multi-Source Data from Smartphones.

Smartphones with integrated sensors play an important role in people's lives, and in advanced multi-sensor fusion navigation systems, the use of individual sensor information is crucial. Because of the different environments, the weights of the sensors will be different, which will also affect the method and results of multi-source fusion positioning. Based on the multi-source data from smartphone sensors, this study explores five types of information-Global Navigation Satellite System (GNSS), Inertial Measurement Units (IMUs), cellular networks, optical sensors, and Wi-Fi sensors-characterizing the temporal, spatial, and mathematical statistical features of the data, and it constructs a multi-scale, multi-window, and context-connected scene sensing model to accurately detect the environmental scene in indoor, semi-indoor, outdoor, and semi-outdoor spaces, thus providing a good basis for multi-sensor positioning in a multi-sensor navigation system.

The catalytic performance of (ZrO) ( = 1-4, 12) clusters for Suzuki-Miyaura cross-coupling: a DFT study.

Superatoms are special clusters with similar physicochemical properties to individual atoms in the periodic table, which open up new avenues for exploring inexpensive catalysts. Given that the ZrO superatom possesses the same number of valence electrons as a Pd atom, the mechanisms of the Suzuki-Miyaura reaction catalyzed by (ZrO) ( = 1-4) clusters have been investigated and compared with the corresponding Pd ( = 1-4) species to explore superatom-based catalysts for the formation of C-C bonds a density functional theory (DFT) study. It was interesting to find that the catalytic activities of (ZrO) ( = 1-4) towards the Suzuki-Miyaura reaction gradually improved as the cluster size increased.

A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage.

Articular cartilage injury (ACI) remains one of the key challenges in regenerative medicine, as current treatment strategies do not result in ideal regeneration of hyaline-like cartilage. Enhancing endogenous repair via microRNAs (miRNAs) shows promise as a regenerative therapy. miRNA-140 and miRNA-455 are two key and promising candidates for regulating the chondrogenic differentiation of mesenchymal stem cells (MSCs).

Enhancing rural healthcare through internet-based remote collaborative outpatient services: A comprehensive evaluation in Changzhi, Shanxi Province.

Background: The advancement of digital technology, particularly telemedicine, has become crucial in improving healthcare access in rural areas. By integrating cloud computing and mHealth technologies, Internet-based Collaborative Outpatient Clinics offer a promising solution to overcome the limitations of traditional healthcare delivery in underserved communities.

Methods: A trial was conducted in 4 counties of Changzhi City in Shanxi Province, China.

Profiling of Phakopsora pachyrhizi transcriptome revealed co-expressed virulence effectors as prospective RNA interference targets for soybean rust management.

Soybean rust (SBR), caused by an obligate biotrophic pathogen Phakopsora pachyrhizi, is a devastating disease of soybean worldwide. However, the mechanisms underlying plant invasion by P. pachyrhizi are poorly understood, which hinders the development of effective control strategies for SBR.

Heat shock protein (Hsp27)-ceramide synthase (Cers1) protein-protein interactions provide a new avenue for unexplored anti-cancer mechanism and therapy.

Hsp27 is a member of the small heat-shock proteins (sHSPs) - the known cellular line of defence against abnormal protein folding behaviors. Nevertheless, its upregulation is linked to a variety of pathological disorders, including several types of cancers. The ceramide synthases (CerS) mediate the synthesis of ceramide, a critical structural and signaling lipid.

Intratumoral habitat radiomics based on magnetic resonance imaging for preoperative prediction treatment response to neoadjuvant chemotherapy in nasopharyngeal carcinoma.

Purpose: The aim of this study is to determine intratumoral habitat regions from multi-sequences magnetic resonance imaging (MRI) and to assess the value of those regions for prediction of patient response to neoadjuvant chemotherapy (NAC) in nasopharyngeal carcinoma (NPC).

Materials And Methods: Two hundred and ninety seven patients with NPC were enrolled. Multi-sequences MRI data were used to outline three-dimensional volumes of interest (VOI) of the whole tumor.

Effects of humic electron mediators on reductive dechlorination of polychlorinated biphenyl by consortia enriched from terrestrial and marine environments.

Humic electron mediators can facilitate the reductive dehalogenation of organohalogenated compounds by accelerating electron transfer. To investigate the effect of humic electron mediators on the microbial anaerobic reductive dechlorination of Polychlorinated biphenyls (PCBs), three types of humic electron mediators, humin (HM), humic acid (HA), and anthraquinone-2,6-disulfonic acid (AQDS, HA analogs), were added to PCB dechlorination cultures enriched from different sources in terrestrial and marine environments (T and M cultures). The results showed that meta- and para-site dechlorination occurred in the M culture, while only meta-site dechlorination occurred in the T culture.

De Novo Rational Design of Peptide-Based Protein-Protein Inhibitors (Pep-PPIs) Approach by Mapping the Interaction Motifs of the PP Interface and Physicochemical Filtration: A Case on p25-Cdk5-Mediated Neurodegenerative Diseases.

Protein-protein interactions, or PPIs, are a part of every biological activity and have been linked to a number of diseases, including cancer, infectious diseases, and neurological disorders. As such, targeting PPIs is considered a strategic and vital approach in the development of new medications. Nonetheless, the wide and flat contact interface makes it difficult to find small-molecule PP inhibitors.

Revisiting the photocharging effect on the BiVO (010) surface by identifying the charge reaction kinetics.

The alteration of intermediates on the (010) facet of BiVO leads to variations in charge accumulation numbers before overcoming the rate-determining step, which accounts for the enhanced charge transfer for oxygen evolution. This discovery provides insights into the photocharging effect and the photoelectrochemical reaction mechanism.

Large Language Model-Based Natural Language Encoding Could Be All You Need for Drug Biomedical Association Prediction.

Analyzing drug-related interactions in the field of biomedicine has been a critical aspect of drug discovery and development. While various artificial intelligence (AI)-based tools have been proposed to analyze drug biomedical associations (DBAs), their feature encoding did not adequately account for crucial biomedical functions and semantic concepts, thereby still hindering their progress. Since the advent of ChatGPT by OpenAI in 2022, large language models (LLMs) have demonstrated rapid growth and significant success across various applications.

Water Injection Into Coal Seams for Outburst Prevention: The Coupling Effect of Gas Displacement and Desorption Inhibition.

Gassy coal seams generally have low permeability and dry coal bodies, which are susceptible to coal and gas outburst hazards in the process of mining. Water injection into coal seams can significantly alter the gas release rate and flow behavior. However, water has dual effects on coal seams: gas displacement and water-locking, and the coupling mechanism of these two effects is not clear in the whole process of coal seam water injection.

TG-Net: Using text prompts for improved skin lesion segmentation.

Automatic skin segmentation is an efficient method for the early diagnosis of skin cancer, which can minimize the missed detection rate and treat early skin cancer in time. However, significant variations in texture, size, shape, the position of lesions, and obscure boundaries in dermoscopy images make it extremely challenging to accurately locate and segment lesions. To address these challenges, we propose a novel framework named TG-Net, which exploits textual diagnostic information to guide the segmentation of dermoscopic images.

CTHRC1 is a prognostic biomarker correlated with immune infiltration in head and neck squamous cell carcinoma.

Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, characterized by high morbidity, high mortality, and poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) has been shown to be highly expressed in various cancers. However, its biological functions, potential role as a biomarker, and its relationship with immune infiltrates in HNSCC remain unclear.