Synopsis of recent research by authors named "Zhichao Yue"
Zhichao Yue's recent research focuses on the roles of transient receptor potential melastatin 2 (TRPM2) in ischemic stroke, demonstrating its involvement in excitotoxicity and blood-brain barrier degradation during ischemic events.
Findings reveal that TRPM2 interacts with protein kinase Cγ (PKCγ) and that disrupting this interaction can alleviate neuronal damage caused by NMDA receptor activation, offering a potential therapeutic strategy.
Additionally, Yue's studies investigate TRPM2's role in atherosclerosis, identifying the TRPM2-CD36 inflammatory axis in macrophages as a protective mechanism against this condition.