Antifungal activity of ruthenium (II) complex combined with fluconazole against drug-resistant Candida albicans in vitro and its anti-invasive infection in vivo.

With the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs.

Synthesis and Antifungal Evaluation of New Azole Derivatives against .

In this study, we designed and prepared a series of new azole derivatives by recombination of fluconazole (FLC) and ketoconazole units, and antifungal activities against were evaluated. The results indicated that most azoles showed good antifungal activity against the drug-sensitive strain, especially compounds , , , , , , , and , which displayed better antifungal activity (MIC < 1.0 μg/mL) than FLC against SC5314.

Cyclometalated iridium(III) complexes combined with fluconazole: antifungal activity against resistant .

() is a ubiquitous clinical fungal pathogen. In recent years, combination therapy, a potential treatment method to overcome resistance, has gained traction. In this study, we synthesized a series of cyclometalated iridium(III) complexes with the formula [Ir(C-N)(tpphz)](PF) (C-N = 2-phenylpyridine (ppy, in ), 2-(2-thienyl)pyridine (thpy, in ), 2-(2,4-difluorophenyl) pyridine (dfppy, in ), tpphz = tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine) and polypyridyl ruthenium(II) complexes with the formula [Ru(N-N)(tpphz)](PF) (N-N = 2,2'-bipyridine (bpy, in ), 1,10-phenanthroline (phen, in ), 4,7-diphenyl-1,10-phenanthroline (DIP, in )), and investigated their antifungal activities against drug-resistant and their combination with fluconazole (FLC).

Three new diterpenoids isolated from Hand.-Mazz and their anti-fungal activity.

Three new diterpenoids, named nematocynine A-C (1-3), together with twelve known compounds (4-15) were isolated from the aerial part of Hand.-Mazz (Hereinafter referred to ). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data.

Lactobacillus murinus: A key factor in suppression of enterogenous Candida albicans infections in Compound Agrimony enteritis capsules-treated mice.

Ethnopharmacological Relevance: Compound Agrimony (FuFangXianHeCao, FFXHC) Enteritis Capsules is an ethnomedicine that is derived from Yi Nationality Herbal Medicine for enteritis treatment. We found that FFXHC reduced the mortality outcomes in enterogenic Candida albicans infected mice models and increased the abundance of Lactobacillus murinus in the intestines. Lactobacillus murinus exhibited comparable therapeutic effects to those of FFXHC in enterogenic Candida albicans infected mice.