Reverse anti-breast cancer drug resistance effects by a novel two-step assembled nano-celastrol medicine.

Multidrug resistance (MDR) has become one of the most intractable problems in clinics as it would cause failure in chemotherapy. In this study, we demonstrated that a nanoscale self-assembled nanomedicine, which almost consisted of a pure chemo-drug, could efficiently overcome MDR. Celastrol (CST) was directly assembled into a discrete nanomedicine by precipitation, and then CST nanoparticles (CNPs) inhibited drug efflux pumps by activating HSF-1 expression and promoting HSF-1 translocation into nucleus to suppress the Pgp expression.

Optimization and testing of suspension system of electric mini off-road vehicles.

Mini vehicles with a small wheelbase are extremely sensitive to road roughness. The aim of this study is to explore the influence of road information on ride comfort and enhance the ride comfort of mini vehicles. According to the 5-degree-of-freedom vibration model of an electric mini off-road vehicle, the partial differential matrix equation of system motion is established using the Lagrange method, and the frequency response characteristic of the system is analyzed.