TFAP2A drives non-small cell lung cancer (NSCLC) progression and resistance to targeted therapy by facilitating the ESR2-mediated MAPK pathway.

Cancer is among the leading causes of death related diseases worldwide, and lung cancer has the highest mortality rate in the world. Transcription factors (TFs) constitute a class of structurally and functionally intricate proteins. Aberrant expression or functional deficiencies of transcription factors may give rise to abnormal gene expression, contributing to various diseases, including tumours.

Self-Healing Yet Strong Actuator Materials with Muscle-Like Diastole and Contraction via Multilevel Relaxations.

Skeletal muscles represent a role model in soft robotics featuring agile locomotion and incredible mechanical robustness. However, existing actuators lack an optimal combination of actuation parameters (including actuation modes, work capacity, mechanical strength, and damage repair) to rival biological tissues. Here, a biomimetic structural design strategy via multilevel relaxations (α/β/γ/δ-relaxation) modulation is proposed for mechanical robust and healable actuator materials with muscle-like diastole and contraction abilities by orientational alignment of dendritic polyphenol-modified nano-assembles in eutectogels.

Simulation Methods for MEMS S&A Devices for 2D Fuze Overload Loading.

An experimental testing system for the two-dimensional (2D) fuze overload loading process was designed to address the loading issues of recoil overload and centrifugal overload in fuze safety and arming (S&A) device. By incorporating centrifuge rotation energy storage, impact acceleration simulation, and equivalent centrifugal rotation simulation, a block equipped with a fuze S&A device accelerated instantly upon having impact from a centrifuge-driven impact hammer, simulating recoil overload loading. The impact hammer was retracted instantaneously by adopting an electromagnetic brake, which resulted in the centrifugal rotation of the block around its track, to simulate the centrifugal overload loading.

Fatigue Behavior of Sandstone Exposed to Cyclic Point-Loading: Implications for Improving Mechanized Rock Breakage Efficiency.

During the process of mechanized excavation, rock is essentially subjected to cyclic point loading (CPL). To understand the CPL fatigue behavior of rock materials, a series of CPL tests are conducted on sandstone samples by using a self-developed vibration point-load apparatus. The effects of loading frequency and waveform on rock fatigue properties under CPL conditions are specifically investigated.

Integrated Metabolites and Transcriptomics at Different Growth Stages Reveal Polysaccharide and Flavonoid Biosynthesis in .

is a perennial parasitic herb, and its stem is widely used as a traditional Chinese medicine, which largely relies on bioactive compounds (e.g., polysaccharides, flavonoids, and triterpenes).

Levodopa-Induced Ocular Dyskinesia in an Early-Onset Parkinson Disease Patient With GBA Mutation.

Objectives: The aim of this study was to report a case of levodopa-induced ocular dyskinesia in an early-onset Parkinson disease patient and to investigate the pathogenic gene.

Methods: We report the case of a 49-year-old male patient with a 13-year history of Parkinson disease. Involuntary eye movements were noticed after treatment with amantadine for limb dyskinesias.

ERP: An elastic resource provisioning approach for cloud applications.

Elasticity is the key technique to provisioning resources dynamically in order to flexibly meet the users' demand. Namely, the elasticity is aimed at meeting the demand at any time. However, the aforementioned approaches usually provision virtual machines (VMs) in a coarse-grained manner just by the CPU utilization.

A multiobjective migration algorithm as a resource consolidation strategy in cloud computing.

To flexibly meet users' demands in cloud computing, it is essential for providers to establish the efficient virtual mapping in datacenters. Accordingly, virtualization has become a key aspect of cloud computing. It is possible to consolidate resources based on the single objective of reducing energy consumption.

Two new chromene derivatives from Artemisia songarica.

Two new chromene derivatives, songaricachromenes A (1) and B (2), were isolated from Artemisia songarica, along with 10 known compounds (3-12). The structures and stereochemistry of the new compounds were elucidated by analyses of the NMR, MS, and electronic circular dichroism (ECD) data. All the isolates (1-12) were evaluated for their NO inhibitory effects on LPS-stimulated BV-2 microglial cells.

An energy-efficient failure detector for vehicular cloud computing.

Failure detectors are one of the fundamental components for maintaining the high availability of vehicular cloud computing. In vehicular cloud computing, lots of RSUs are deployed along the road to improve the connectivity. Many of them are equipped with solar battery due to the unavailability or excess expense of wired electrical power.

Prediction of Three-Dimensional Downward Flame Spread Characteristics over Poly(methyl methacrylate) Slabs in Different Pressure Environments.

The present study is aimed at predicting downward flame spread characteristics over poly(methyl methacrylate) (PMMA) with different sample dimensions in different pressure environments. Three-dimensional (3-D) downward flame spread experiments on free PMMA slabs were conducted at five locations with different altitudes, which provide different pressures. Pressure effects on the flame spread rate, profile of pyrolysis front and flame height were analyzed at all altitudes.

A Weibull distribution accrual failure detector for cloud computing.

Failure detectors are used to build high availability distributed systems as the fundamental component. To meet the requirement of a complicated large-scale distributed system, accrual failure detectors that can adapt to multiple applications have been studied extensively. However, several implementations of accrual failure detectors do not adapt well to the cloud service environment.

An investigation of crosstalk between Wnt/β-catenin and transforming growth factor-β signaling in androgenetic alopecia.

Background: Wnt and transforming growth factor-β (TGF-β) signaling pathways are known to be involved in the pathogenesis of androgenetic alopecia (AGA). However, the way that Wnt and TGF-β signaling is altered in patients with AGA and whether there exists a crosstalk between them in pathogenetic process of AGA remain unclear.

Objectives: To investigate the expression of Wnt and TGF-β signaling and the crosstalk between these 2 signaling pathways in AGA.

Superconducting nanowire single photon detector at 532 nm and demonstration in satellite laser ranging.

Superconducting nanowire single-photon detectors (SNSPDs) at a wavelength of 532 nm were designed and fabricated aiming to satellite laser ranging (SLR) applications. The NbN SNSPDs were fabricated on one-dimensional photonic crystals with a sensitive-area diameter of 42 μm. The devices were coupled with multimode fiber (ϕ = 50 μm) and exhibited a maximum system detection efficiency of 75% at an extremely low dark count rate of <0.

Experimental and Numerical Study on Effect of Sample Orientation on Auto-Ignition and Piloted Ignition of Poly(methyl methacrylate).

In this work, the effect of seven different sample orientations from 0° to 90° on pilot and non-pilot ignition of PMMA (poly(methyl methacrylate)) exposed to radiation has been studied with experimental and numerical methods. Some new and significant conclusions are drawn from the study, including a U-shape curve of ignition time and critical mass flux as sample angle increases for pilot ignition conditions. However, in auto-ignition, the ignition time and critical mass flux increases with sample angle α.