Publications by authors named "Zhibin Wang"

We developed a novel method utilizing surface-enhanced Raman spectroscopy (SERS) with calcium ion-modified silver nanoparticles as the enhancing substrate. This approach enables label-free detection of the dissolution rate of bisphosphonates. This technique is fast, sensitive, and highly reproducible, significantly advancing drug quality control.

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A refined synthesis of 1,4,2-diazaphospholidine-3,5-dione derivatives was achieved through a cyclization reaction involving Na(OCP) and isocyanates. Na(OCP) was demonstrated to be a relatively stable and safe source of phosphorus, enabling the production of diverse 1,4,2-diazaphospholidine-3,5-dione derivatives with high yields. The reaction proceeds efficiently under catalyst-free and mild conditions.

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Mentha haplocalyx Briq. (M. haplocalyx), a notable member of the Lamiaceae family, occupies a significant role in the realm of health foods and botanical medicines.

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Objective: The aim of this research was to investigate the specific regulatory role of miR-6760-5p in angiogenesis in moyamoya disease.

Methods: HUVECs were transfected with miR-6760-5p inhibitor and mimics fragments, then subjected to assays for cell proliferation, migration, and tube formation. Subsequently, downstream target genes of miR-6760-5p were predicted and the protein expression levels of these genes were evaluated.

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Biological processes are widely used technologies for water decontamination, but they are often limited by insufficient bioavailable carbon sources or biorecalcitrant contaminants. The recently developed photocatalytic material-microorganism hybrid (PMH) system combines the light-harvesting capacities of photocatalytic materials with specific enzymatic activities of whole cells, efficiently achieving solar-to-chemical conversion. By integrating the benefits of both photocatalysis and biological processes, the PMH system shows great potential for water decontamination.

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The emergence of pathogenic bacteria resistant to conventional antibiotics is becoming increasingly challenging. Plant-derived flavonoids are potential alternatives to antibiotics, owing to their antimicrobial properties. However, the molecular mechanisms through which they inhibit the growth of pathogenic microorganisms remain unclear.

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The recently proposed partial denitrification (PD), terminating nitrate reduction to nitrite, has been regarded as a promising alternative to nitrite supplying for anammox bacteria. The most important aspect of the PD process for engineering application is the stable and continuous supply of nitrite. However, the activity of nitrate reductase is often higher than that of nitrite reductase (NIR), making it difficult to accumulate nitrite during the denitrification process.

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The Paeonia genus, the most distinctive representative of the Paeoniaceae family, holds significant edible and medicinal value. Its plants are rich in chemical constituents, including polysaccharides, phenols, terpenes, and flavonoids. Among these, Paeonia polysaccharide (PPS) is a key bioactive component, exhibiting diverse biological activities such as anti-cancer, anti-depressant, anti-oxidant, anti-inflammatory, anti-bacterial, immunomodulatory activities and therapeutical effect of diabetic kidney disease.

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Macrophages possess M1/M2 polarization, which perform an essential role in immunology and inflammation studies. However, few studies have investigated the specific molecules involved in the polarization process beyond its induction and characterization. Here, we determined that the molecule S1PR1 regulates M1 polarization in macrophages and that the surface marker CD83 is involved in this process.

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Immobilized hydrolase not only reduces the production of antibiotic-resistant bacteria, but also effectively improves the stability of hydrolase in external use. In this study, phage hydrolase LysSSE1 against Gram-negative bacteria were surface immobilized and optimized for their bactericidal activity. Different anti-pathogen surface materials were prepared, where LysSSE1 was immobilized on the glass surface with a silica-affinity peptide and into which different peptide linkers were introduced.

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Background And Purpose: Activation of AMP-activated protein kinase (AMPK) is essential in maintaining the epithelial tight junction (TJ) barrier. Berberine, a phytochemical AMPK agonist, has been widely reported to ameliorate colitis. Berberine or AMPK activation inhibits cytoskeletal contraction induced by myosin light chain kinase (MLCK), thereby ameliorating TJ barrier defects.

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Background: Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disease that lacks effective treatments. Qingchang Wenzhong Decoction (QCWZD) is a clinically effective herbal prescription that has been proven to attenuate intestinal inflammation in IBD. However, its molecular mechanism of action has not been clearly elucidated.

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Polygala japonica Houtt. (P. japonica), a member of the Polygala genus in the Polygalaceae family, has been historically utilized in traditional folk medicine as an expectorant, anti-inflammatory, anti-bacterial, and anti-depressant agent.

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Article Synopsis
  • - The study examines how human-made volatile organic compounds (VOCs) affect ozone formation, emphasizing their measurement in a light industrial city from May to July 2021, where alkanes were the most prevalent VOCs contributing over half to total VOC levels.
  • - It was found that the environmental conditions shifted from NO saturation to radical saturation during the measurement period, indicating a change in the ozone production regime and underscoring the need for flexible control strategies based on these transitions.
  • - Five sources of VOCs were identified, with significant contributions from solvent and gasoline use (32.3%) and vehicular exhausts (19.9%), while higher temperatures and radiation were linked to increased VOC emissions, stressing the importance of tailored strategies for
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Article Synopsis
  • This review discusses the importance of lymphopenia (low lymphocyte levels) in sepsis and its impact on patient outcomes, highlighting the condition's role in immunosuppression and sepsis severity.
  • It explores how lymphopenia correlates with sepsis prediction markers and potential treatment targets.
  • The paper also outlines the main causes of septic lymphopenia and suggests that future research should focus on enhancing the growth of lymphocytes as a possible therapeutic approach.
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Purpose: This study aimed to evaluate fetal left ventricular function (LVF) in pregnant women with obstetric antiphospholipid syndrome (OAPS) by Doppler ultrasound and developed a clinical nomogram to predict adverse perinatal outcomes.

Methods: In this prospective observational study, 105 pregnant women were enrolled and divided into the OAPS cohort (n = 60) and the control cohort (n = 45). Fetal cardiac function parameters were collected and compared between two cohorts.

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Cannabis sativa fruit (Cannabis Fructus) refers to the dried and ripe fruit of Cannabis sativa L. It is widely distributed in the northeast, North, and South China. It has medicinal, ecological, and economic values.

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The Arabidopsis thaliana aluminum-activated malate transporter 9 (AtALMT9) functions as a vacuolar chloride channel that regulates the stomatal aperture. Here, we present the cryoelectron microscopy (cryo-EM) structures of AtALMT9 in three distinct states. AtALMT9 forms a dimer, and the pore is lined with four positively charged rings.

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Article Synopsis
  • * Conducted as a double-blind, randomized trial, 46 participants received either active tACS or sham stimulation over 30 sessions, with evaluations on cognitive tests and brain activity at multiple time points.
  • * Results indicated no significant difference in the primary cognitive measure, but the tACS group showed improvements in secondary cognitive assessments, linking enhanced hippocampal activity with cognitive performance, despite improvements not lasting at the 3-month follow-up.
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The poor operational stability of perovskite light-emitting diodes (PeLEDs) remains a major obstacle to their commercial application. Achieving high brightness and quantum efficiency at low driving voltages, thus effectively reducing heat accumulation, is key to enhancing the operational lifetime of PeLEDs. Here, we present a breakthrough, attaining a record-low driving voltage while maintaining high brightness and efficiency.

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L. (, commonly known as "Bai Qu Cai" in China, belongs to the genus of the Papaveraceae family. It has rich medicinal value, such as alleviating coughs, asthma, spasms and pain.

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Swine wastewater application can introduce antibiotics, antibiotic resistance genes (ARGs) into environments. Herein, the full-scale transmission of antibiotics, ARGs and their potential carriers from an intensive swine feedlot to its surroundings were explored. Results showed that lincomycin and doxycycline hydrochloride were dominant antibiotics in this ecosystem.

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Background: Irreversible pulmonary fibrosis induced by paraquat is the most prevalent cause of death in patients with paraquat poisoning. Pulmonary fibrosis is characterized by abnormal deposition of extracellular matrix (ECM). Currently, the role of fibrotic ECM microenvironment in paraquat-induced pulmonary fibrosis has not been established.

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