VCT MXene modification enabling stable sodium metal anodes.

In this work, we employ a simple mechanical mixing strategy to directly incorporate VCT MXene with metallic Na as an anode for Na metal batteries, which enables highly reversible and dendrite-free properties during the Na plating/stripping processes. Our findings reveal that the VCT host in the Na metal anode promotes uniform Na deposition, attributed to its abundant -O and -F surface functional groups, and we believe that this work provides a feasible approach to improve the electrochemical performance of sodium metal anodes.

cGAS mRNA-based Immune Agonist Promotes Vaccine Responses and Antitumor Immunity.

mRNA vaccines are recognized as potent tools for immunization against viral diseases and cancer. However, the lack of a vaccine adjuvant limits the efficacy of these treatments. Here, we used cGAS mRNA, which encodes the DNA innate immune sensor, complexed with lipid nanoparticles (LNPs) to boost the immune response.

Weakly solvated perfluorinated electrolyte for high-temperature sodium-layered oxide cathodes.

The stability of the electrode-electrolyte interface in layered oxides is enhanced by electrolyte design criteria. A weakly-solvated electrolyte containing ethyl trifluoroacetate solvents with perfluorinated functional groups can restrain electrolyte decomposition and structural degradation when subjected to heat attack, exhibiting superior cycling durability at 60 °C compared to other fluorinated electrolytes.

Individualized therapy guided by single-cell sequencing in anti-GABAR encephalitis.

We presented a patient with refractory anti-GABA-R encephalitis, and constructed libraries for single-cell sequencing from the patient's peripheral blood mononuclear cells (PBMCs), cerebrospinal fluid cells, as well as four healthy volunteer's PBMCs. A distinct group of monoclonal CD8 T cells and an abnormal JAK-STAT signaling pathway was implicated in the disease. The cross-reactive protein LIM-domain-only protein 5 (LMO5) identified in the patient's thymoma, prompted the activation of the specific CD8 T cells.

Durable Acidic Oxygen Evolution Via Self-Construction of Iridium Oxide/Iridium-Tantalum Oxide Bi-Layer Nanostructure with Dynamic Replenishment of Active Sites.

Proton exchange membrane (PEM) water electrolysis presents considerable advantages in green hydrogen production. Nevertheless, oxygen evolution reaction (OER) catalysts in PEM water electrolysis currently encounter several pressing challenges, including high noble metal loading, low mass activity, and inadequate durability, which impede their practical application and commercialization. Here we report a self-constructed layered catalyst for acidic OER by directly using an Ir-Ta-based metallic glass as the matrix, featuring a nanoporous IrO surface formed in situ on the amorphous IrTaO nanostructure during OER.

Spatial and Temporal Characteristics of Riverine Fungal Communities and Their Responses to Environmental Factors in China's Largest Jiang-Flavor Baijiu-Producing Region.

The Chishui River is the prime production area for Jiang-flavor Baijiu in China, with 85% of the country's production capacity. To understand the spatial and temporal characteristics of fungal communities in the water column of the Maotai reach of the Chishui River and the relationship between fungal communities and environmental factors as well as the brewing of Jiang-flavor Baijiu, we analyzed the fungal species richness and diversity, structural changes, community composition, and correlation with environmental factors in different seasons and river reaches of the Chishui River Maotai reach. It was found that species richness and diversity followed the following seasonal pattern: summer > autumn > winter ≈ spring.

Treatment of Mild-to-moderate Progressive Hemifacial Atrophy by Acellular Dermal Matrix Combined With Preoperative Digital Evaluation.

Background: Progressive hemifacial atrophy (PHA) is a rare condition marked by the gradual degeneration of skin, soft tissues, muscles, and, in advanced stages, bone. The primary approach for managing PHA involves surgical interventions to reconstruct and restore the facial contour. The current treatments each present several limitations.

Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a "hit-and-run" paradigm.

Background: Helicobacter pylori (H. pylori) infection contributes significantly to gastric cancer (GC) progression. The intrinsic mechanisms of H.

The effect of breastfeeding on early childhood caries: A prospective cohort study of 3-year-old Chinese children.

Objectives: Early childhood caries (ECC) is a highly prevalent disease. Breastfeeding is a beneficial feeding method, but existing studies lack consensus on its association with the occurrence of ECC. This study aimed to analyse the effect of breastfeeding on ECC occurrence and possible microbiological mechanisms.

Descriptive epidemiology and prognostic factors of atypical teratoid/rhabdoid tumors in the United States, 2001-2021.

Atypical teratoid rhabdoid tumor (AT/RT) is a rare embryonal central nervous system tumor with a dismal prognosis that occurs mostly in early childhood. Since recent epidemiological and prognostic information is limited, we aimed to describe and analyze AT/RT-related incidences, temporal trends and prognostic factors. Incidence and survival data between 2001 and 2021 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database.

Defense-Related Enzyme Activities and Metabolomic Analysis Reveal Differentially Accumulated Metabolites and Response Pathways for Sheath Blight Resistance in Rice.

Rice sheath blight (RSB), caused by the pathogenic fungus , poses a significant threat to global food security. The defense mechanisms employed by rice against RSB are not well understood. In our study, we analyzed the interactions between rice and by comparing the phenotypic changes, ROS content, and metabolite variations in both tolerant and susceptible rice varieties during the early stages of fungal infection.

Artificial Intelligence-Enabled Novel Atrial Fibrillation Diagnosis System Using 3D Pulse Perception Flexible Pressure Sensor Array.

Atrial fibrillation (AF) as one of the most common cardiovascular diseases has attracted great attention due to its high disability and mortality rate. Thus, a timely and effective recognition method for AF is of great importance for diagnosing and preventing it. Herein, we proposed a novel intelligent sensing and recognition system for AF which combined Traditional Chinese Medicine (TCM), flexible wearable electronic devices, and artificial intelligence.

Up to the mountains and down to the wetlands: Thirty years' migration of cropland in China since 1990.

Cropland changes are crucial aspects of land-use/land-cover changes (LUCC), which profoundly influence agricultural sustainability and terrestrial ecosystem health. In the context of dynamic shifts within the natural environment, coupled with the evolution of agricultural practices and the transformation of agrarian systems and policies, the trajectory of farmland alteration has exhibited significant divergence across various nations and regions. This article delves into the intriguing phenomenon of China's cropland migrating up to mountains and down to wetlands and analyses its spatiotemporal pattern evolution from 1990 to 2020.

A bismuth oxide-modified copper host achieving bubble-free and stable potassium metal batteries.

Due to the minimal electrochemical oxidation-reduction potential, the potassium (K) metal anode has emerged as a focal in K-ion batteries. However, the reactivity of the K metal anode leads to significant side reactions, particularly gas evolution. Mitigating gas generation from K metal anodes has been a persistent challenge in the field.

Defluorinative Multicomponent Cascade Reaction of Trifluoromethylarenes via Photoexcited Palladium Catalysis.

The incorporation of aromatic difluoromethyl motifs has proven to be a fruitful strategy for enhancing the therapeutic profiles of modern pharmaceutical candidates. While the defluorofunctionalization of trifluoromethylarenes offers a promising pathway toward diverse aromatic difluoromethyl compounds, current methods are predominantly limited to two-component reactions. Multicomponent cascade reactions (MCRs) involving a transient aromatic difluoromethyl radical are still uncommon and highly sought after, owing to their capacity to rapidly generate challenging molecular structures.

Analysis of factors influencing family support for child safety seat legislation based on Probit-Adversarial Interpretive Structure model.

Objectives: In recent years, China's motorization process has accelerated, urban road traffic has become increasingly complex, and the safety of children has become increasingly prominent. China aims to encourage the use of child safety seats (CSSs) and stipulates in the Law on the Protection of Minors that "Parents or other guardians of minors take measures, such as equipping child safety seats." However, the utilization rate of such seats in China is still low (<5%, 2021), an important reason is the lack of mandatory legislation.

Sibling bullying victimization and subjective well-being among children across 13 countries: The mediating roles of perceived social support and the moderating role of uncertainty avoidance culture.

Background: While sibling bullying victimization has been recognized as a significant factor detrimentally impacting children's subjective well-being, the underlying mechanisms have yet to be fully elucidated.

Objective: This study seeks to investigate the potential mediating role of perceived social support, encompassing support from family, friend, teacher, and neighbor, as well as the moderating influence of uncertainty avoidance culture.

Participants And Setting: A sample of 19,328 children was obtained from Wave Three of Children's Worlds: International Survey of Children's Well-being in 13 countries.

Mechanisms of evolution and pollution source identification in groundwater quality of the Fen River Basin driven by precipitation.

Groundwater pollution has attracted widespread attention as a threat to human health and aquatic ecosystems. However, the mechanisms of pollutant enrichment and migration are unclear, and the spatiotemporal distributions of human health risks are poorly understood, indicating insufficient groundwater management and monitoring. This study assessed groundwater quality, human health risks, and pollutant sources in the Fen River Basin(FRB).