Immunogenicity Persistence of Different Immunization Regimens of Rabies Vaccine in the 10-60 Years Age Group: A Follow-Up Report Based on Phase III Clinical Trial.

This study evaluated the 12-month persistence of rabies virus-neutralizing antibody (RVNA) following different immunization regimens of freeze-dried human rabies vaccine (Vero cells) in individuals aged 10-60 years within the Chinese population. Number of 600 participants from phase III clinical trials who completed the fullimmunization were randomly assigned into one of three groups, four-dose experimental group, five-dose experimental group, and five-dose control group. The experimental group received the vaccine from Shandong Yeedu Biotechnology Co.

Safety and immunogenicity of freeze-dried human rabies vaccines: A phase 3 clinical trial of Zagreb and Essen regimes.

Recently optimized freeze-dried rabies vaccines (Vero cell) are promising for rabies prevention; however, comparisons of Essen 5-dose and Zagreb 4-dose regimens are needed for clinical applications. This phase III clinical trial aimed to assess the safety and immunogenicity of candidate freeze-dried rabies vaccines developed for human use by Shandong Yeedo Biotechnology (Registration No.: CTR20182016, http://www.

Cost-effectiveness analysis of pharmaceutical care in adult critically ill patients: based on a prospective cohort study.

Background: The medication regimen for critically ill patients is complex and dynamic, leading to a high incidence of drug-related problems. This study aimed to assess the effectiveness and economic efficiency of pharmaceutical care for these patients.

Methods: In this prospective cohort study conducted in a tertiary hospital, adult patients were assigned either to a clinical pharmaceutical care group or a control group based on existing clinical grouping rules.

Development of an Evaluation System for the Prophylactic Use of Antimicrobial Drugs in the Perioperative Period of Class I Surgical Incisions in Neurosurgery.

Background: This study aimed to establish a precise preoperative high-risk factor scoring system and algorithm for antibiotic prophylaxis decision-making, provide guidance for the judicious use of AMP, refine interventions, and ensure the appropriate application of AMP for class I incisions in neurosurgery.

Methods: According to PRISMA guidelines, literature searches, study selection, methodology development, and quality appraisal were performed. The quality of evidence across the study population was assessed using the Newcastle-Ottawa Scale.

Evaluation of the implementation effect of hepatitis C medical insurance reimbursement policy in China: A RWS based on medical institutions.

Objectives: To evaluate the implementation effect of hepatitis C medical insurance reimbursement policy in China from the view of medical institutions.

Methods: The electronic medical record of a top tertiary hospital in Chengdu from January 2014 to December 2020 were extracted, and the interrupted time series model was used to analyze the changes in diagnosis and treatment behavior and disease burden of hepatitis C patients after the implementation of HCV insurance reimbursement policy.

Results: In terms of diagnosis and treatment, the number of visits (β2 = 19.

The effect of intravenous lidocaine on propofol dosage in painless bronchoscopy of patients with COPD.

Background: We tested the hypothesis that intravenous (IV) lidocaine reduces propofol requirements in painless bronchoscopy in patients with chronic obstructive pulmonary disease (COPD).

Methods: A total of 93 patients who underwent bronchoscopy were included in this randomized placebo-controlled study. The patients were randomly divided into two groups.

Patient Preferences For Specialty Pharmacy Services: A Stated Preference Discrete-Choice Experiment in China.

To survey, analyze, and ascertain the preferences for specialty pharmacy services among patients requiring complex care and to provide evidence to support specialty pharmacy service decision-making in China. To identify essential service attributes and levels, a review of the literature, discussions with specialty pharmacy managers and a pilot questionnaire were conducted. A D-efficient fractional factorial design was used to generate the discrete-choice experiment (DCE) questionnaire.

hPSD: A Hybrid PU-Learning-Based Spammer Detection Model for Product Reviews.

Spammers, who manipulate online reviews to promote or suppress products, are flooding in online commerce. To combat this trend, there has been a great deal of research focused on detecting review spammers, most of which design diversified features and thus develop various classifiers. The widespread growth of crowdsourcing platforms has created large-scale deceptive review writers who behave more like normal users, that the way they can more easily evade detection by the classifiers that are purely based on fixed characteristics.

Evolution of the registration regulations for proprietary Chinese medicines in China.

In this review, we provide a comprehensive overview on the registration of proprietary Chinese medicines (PCMs) in China over the past century by examining published literature and historical data. We will examine this evolving administrative practice for PCMs registration in China, which is divided to the following five stages: (1) initial measures (1915-1948); (2) early development (1949-1965); (3) provincial approval and trial implementation of the "approval number" system (1966-1984); (4) legislation and cleanup (1985-1999); and (5) centralized national approval (2000 until now), offering a panoramic view on the characteristics of PCMs registration management in China.

Local Community Mining on Distributed and Dynamic Networks From a Multiagent Perspective.

Distributed and dynamic networks are ubiquitous in many real-world applications. Due to the huge-scale, decentralized, and dynamic characteristics, the global topological view is either too hard to obtain or even not available. So, most existing community detection methods working on the global view fail to handle such decentralized and dynamic large networks.

Isolation and identification of a new anti-inflammatory cyathane diterpenoid from the medicinal fungus Cyathus hookeri Berk.

A new cyathane diterpene, named as cyathin I (1), as well as two known cyathane diterpenes (12R)-11a,14a-epoxy-13a,14b,15-trihydroxycyath-3-ene (2) and erinacine I (3), were isolated from the liquid culture of Cyathus hookeri Berk. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-3 showed inhibition against nitric oxide production in macrophages with an IC50 value of 15.

SAIL: Summation-bAsed Incremental Learning for Information-Theoretic Text Clustering.

Information-theoretic clustering aims to exploit information-theoretic measures as the clustering criteria. A common practice on this topic is the so-called Info-Kmeans, which performs K-means clustering with KL-divergence as the proximity function. While expert efforts on Info-Kmeans have shown promising results, a remaining challenge is to deal with high-dimensional sparse data such as text corpora.