Paving the path towards carbon neutrality: revealing the contribution of the "Belt and Road" Initiative in mitigating carbon intensity.

This study explores the crucial contribution of the "Belt and Road" Initiative (BRI) in diminishing carbon intensity and facilitating progress towards carbon neutrality, addressing the pressing global issue of climate change. Given its status as the world's foremost carbon emitter, China encounters significant pressure to alleviate its emissions. Launched in 2013, the BRI emphasizes economic development along its route while highlighting environmental protection in the regions involved.

De Novo Sequencing of Synthetic -cysteine Peptide Macrocycles Enabled by "Chemical Linearization" of Compound Mixtures.

A "chemical linearization" approach was applied to synthetic peptide macrocycles to enable their de novo sequencing from mixtures using nanoliquid chromatography-tandem mass spectrometry (nLC-MS/MS). This approach─previously applied to individual macrocycles but not to mixtures─involves cleavage of the peptide backbone at a defined position to give a product capable of generating sequence-determining fragment ions. Here, we first established the compatibility of "chemical linearization" by Edman degradation with a prominent macrocycle scaffold based on -Cys peptides cross-linked with the -xylene linker, which are of major significance in therapeutics discovery.

Impact of inverse unequal height strut structure on the functional performance of an additively manufactured cardiovascular stent.

Recently, additive manufacturing (AM) has been investigated as an innovative method to manufacture stents due to its capability in producing complex and customized structures. In this paper, the cardiovascular stents of M-type and N-type with inverse unequal height strut structure and N-type with equal height strut structure were designed and manufactured by Selective Laser Melting (SLM). Following surface polishing, balloon expansion, plane compression and three-point bending experiments were carried out to evaluate the mechanical performance of the stent.

[Three-dimensional printed 316L stainless steel cardiovascular stent's electrolytic polishing and its mechanical properties].

The interventional therapy of vascular stent implantation is a popular treatment method for cardiovascular stenosis and blockage. However, traditional stent manufacturing methods such as laser cutting are complex and cannot easily manufacture complex structures such as bifurcated stents, while three-dimensional (3D) printing technology provides a new method for manufacturing stents with complex structure and personalized designs. In this paper, a cardiovascular stent was designed, and printed using selective laser melting technology and 316L stainless steel powder of 0-10 µm size.