Adropin, a secreted protein, coded by energy homeostasis-associated gene (Enho), is recently reported to modulate atherogenesis, with endothelial-to-mesenchymal transition (EndMT) involved in the early process. We explored whether adropin may alleviate atherosclerosis by regulating EndMT. We found that an intraperitoneal injection of adropin [105 μg/(kg·d) for 13 weeks] inhibited the progression of high-fat diet (HFD)-induced aortic atherosclerosis in apolipoprotein E-deficient mice (ApoE) and those with double gene deletion (ApoE/Enho), as detected by Oil Red O and haematoxylin-eosin staining.
View Article and Find Full Text PDFBackground Pro-NTs (precursor of neurotrophins) and their receptor p75 are potential targets for preventing microvascular dysfunction induced by myocardial ischemia-reperfusion injury (IRI). p75ECD (ectodomain of neurotrophin receptor p75) may physiologically produce neurocytoprotective effects by scavenging pro-NTs. We therefore hypothesized that p75ECD may have a cardioprotective effect on IRI through microvascular mechanisms.
View Article and Find Full Text PDFThe aim of this study was to investigate whether intermediate kissing balloon dilation (IKBD) is necessary during mini-culotte stenting (MCS) and how it can be properly conducted. MCS was emulated in a bifurcation model with a branch diameter difference (BDD) in three-step sizes of 0.50, 0.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
August 2015
Objective: To study the effect of allitridum on rapidly delayed rectifier potassium current (IKr) in HEK293 cell line.
Methods: HEK293 cells were transiently transfected with HERG channel cDNA plasmid pcDNA3.1 via Lipofectamine.
Four new ent-kaurane diterpenoids, rabdonervosins G-J (1-4, resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR and HR mass spectra.
View Article and Find Full Text PDFBackground And Objective: Hirsutanol A is a novel sesquiterpene compound purified from fungus chondrostereum sp in Sarcophyton tortuosum. Its pharmacologic effect has not been reported yet. This study aimed to investigate cytotoxic effect of Hirsutanol A on hepatocellular carcinoma (HCC) cells and its mechanism.
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