Photoaging Decoded: Extracellular Matrix Alterations and Mechanisms via Mitogen-Activated Protein Kinase/Matrix Metalloproteinase, Transforming Growth Factor-β Pathways, and Glycosaminoglycan Metabolism.

Photoaged skin features an appearance of premature aging induced by external factors, mainly ultraviolet (UV) irradiation. Visible aging signs and increased susceptibility to skin-related diseases triggered by UV irradiation have raised widespread concern. As a critical component of human skin, the extracellular matrix (ECM) provides essential structural, mechanical, and functional support to the tissue.

Preparation of carrageenan fibers promoted by hydrogen bonding in a NaCl coagulation bath.

Carrageenan fibers developed by wet spinning have been extensively studied due to their remarkable flame-retardant characteristics. However, its mechanical properties have not been significantly improved, which limits the further development of carrageenan fibers. Traditionally, the first coagulation bath has been selected as a KCl solution, which can promote the formation of gels from carrageenan without reacting with NaOH to produce precipitates.

Simultaneous Regulation of Organic and Inorganic Components in Interphase by Fiber Separator for High-Stable Sodium Metal Batteries.

Uncontrollable side reactions at the metal interface have been identified as the root cause of the formation of a fragile solid electrolyte interphase, leading to irreversible sodium loss in sodium metal batteries. Here, we proposed an interface engineering strategy that employed a carboxyl functionalized cellulose separator to provide strong dipole moments and induce the cleavage of P-F bond to construct a solid electrolyte interphase (SEI) rich in NaF. In addition, we employed nuclear magnetic resonance technology confirmed that the separator with strong dipole moments prevented the reduction of organic solvents by attracting electrons, thereby inhibiting the formation of organic oligomers.

Mechanical force regulates the paracrine functions of ADSCs to assist skin expansion in rats.

Background: In the repair of massive tissue defects using expanded large skin flaps, the incidence of complications increases with the size of the expanded area. Currently, stem cell therapy has limitations to solve this problem. We hypothesized that conditioned medium of adipose-derived stem cells (ADSC-CM) collected following mechanical pretreatment can assist skin expansion.

Effect of the pre-crosslinking of Ba ions on wet spinning of agar fibers.

Decreased coagulation bath concentration and difficult recovery are classical issues observed during the wet spinning of fibers. In this paper, a novel method was presented for preparing environment-friendly agar fibers using deionized water as the coagulation and stretch baths. The addition of Ba into the spinning solution increased the crosslinking time and improved the performance of spinning solution.

3D density imaging using gravity and gravity gradient in the wavenumber domain and its application in the Decorah.

Density imaging is a method that uses the inversion of the gravity and gravity gradient spectra in the wavenumber domain to create accurate 3D reconstructions of subsurface density distributions. This approach offers computational efficiency and rapid calculations. This research used preliminary inversions to examine the spectral characteristics of gravity and gravity gradient anomalies, as well as the resulting models, were scrutinized through preliminary inversions.

Effects of microenvironment and biological behavior on the paracrine function of stem cells.

Mesenchymal stem cells (MSCs), the most well-studied cell type in the field of stem cell therapy, have multi-lineage differentiation and self-renewal potential. MSC-based therapies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore function. An increasing body of evidence demonstrates that paracrine function is central to the effects of MSC-based therapy.

Depth distribution of Moho model and tectonic patterns in South China Sea and adjacent areas.

This study aims to investigate the depth distribution of Mohorovicic discontinuity (Moho) and its relationship with the tectonic pattern of the South China Sea and adjacent areas. To achieve this, the spatial characteristics of the full tensor gravity gradient data are analyzed to identify 17 large and deep faults and to divide the study area into 9 tectonic units with distinct geological structures. Using a three-dimensional (3D) interface inversion method, the Moho depth is determined, constrained by the Moho depth information obtained from sonar-buoy detection and submarine seismograph detection profiles.

Fabrication and Characterization of Carrageenan/ZnO/Chitosan Composite Films.

In this study, a high-performance carrageenan/ZnO/chitosan composite film (F) was fabricated by the solution/dispersion casting method and layer-by-layer method. The first layer was nano-ZnO dispersed in carrageenan solution, and the second layer was chitosan dissolved in acetic acid. The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of F were evaluated compared with a carrageenan film (F) and carrageenan/ZnO composite film (F).

Ultrasonographic manifestations and the effective diagnosis of epididymal leiomyosarcoma: Case report and systematic literature review.

Background: Epididymal leiomyosarcoma is an extremely rare tumor. In this study, we describe the sonographic features of this uncommon tumor.

Methods: A case of epididymal leiomyosarcoma diagnosed at our institute was retrospectively analyzed.

Long non-coding RNA expression profiles in neutrophils revealed potential biomarker for prediction of renal involvement in SLE patients.

Objective: The long non-coding RNA plays an important role in inflammation and autoimmune diseases. The aim of this study is to screen and identify abnormally expressed lncRNAs in peripheral blood neutrophils of SLE patients as novel biomarkers and to explore the relationship between lncRNAs levels and clinical features, disease activity and organ damage.

Methods: RNA-seq technology was used to screen differentially expressed lncRNAs in neutrophils from SLE patients and healthy donors.

Comparison of Two Different Preparation Methods of Wet-Spun Carrageenan Fibers Directly from Extractions.

In order to improve the characters of carrageenan fibers, two different process methods were presented in this study. Dopes prepared directly from extraction by Route A-adding NaOH after extraction-or Route B-using NaOH solution to extract and carrageenan fibers (Fibers A and Fibers B)-were obtained using the wet spinning process using barium chloride as the coagulant at room temperature. The properties of dopes were studied by dynamic light scattering and gel permeation chromatography.

High-strength carrageenan fibers with compactly packed chain structure induced by combination of Ba and ethanol.

Carrageenan fibers have attractive applications in textile, but their low strength remains a problem that needs to be urgently addressed. In this work, a novel facile, environmental friendly method for fabricate high-strength carrageenan fibers is proposed. It involves the crosslinking of a small amount of Ba ions in the carrageenan solution, followed by using recyclable alcohol in coagulation and stretching baths.

Cooking-Inspired Versatile Design of an Ultrastrong and Tough Polysaccharide Hydrogel through Programmed Supramolecular Interactions.

Simultaneously achieving strength and toughness in soft materials remains a challenge, especially for physically crosslinked hydrogels with many inactive interaction sites. In this work, inspired by the cooking of thick soup in China, a facile method that includes free water evaporation of the diluted pregel solution followed by crosslinking (WEC) is proposed to fabricate polysaccharide hydrogels. Herein, without the constraints of viscosity and crosslinking, polymer chains can homogenously approach as much as possible, thereby enabling the transformation of inactive supramolecular interaction (H-bonding and ionic coordination) sites into active sites until reaching the maximum level.

Identification of Renal Long Non-coding RNA RP11-2B6.2 as a Positive Regulator of Type I Interferon Signaling Pathway in Lupus Nephritis.

Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE). Type I interferon (IFN-I) is associated with the pathogenesis of LN. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of SLE, however, the roles of lncRNAs in LN are still poorly understood.

Preparation of Ion-Exchanged TEMPO-Oxidized Celluloses as Flame Retardant Products.

Cellulose, as one of the most abundant natural biopolymers, has been widely used in textile industry. However, owing to its drawbacks of flammability and ignitability, the large-scale commercial application of neat cellulose is limited. This study investigated some TEMPO-oxidized cellulose (TOC) which was prepared by selective TEMPO-mediated oxidation and ion exchange.

Preparation of CdTe/Alginate Textile Fibres with Controllable Fluorescence Emission through a Wet-Spinning Process and Application in the Trace Detection of Hg Ions.

Fluorescent textile fibres (FTFs) are widely used in many industrial fields. However, in addition to fibres with good fluorescence, fibres with excellent colour controllability, structural stability and appropriate mechanical strength still need to be developed. In this work, CdTe/alginate composite FTFs are prepared by taking advantage of the interactions between CdTe nanocrystals (NCs) and alginate macromolecules via a wet-spinning machine with a CaCl₂ aqueous solution as the coagulation bath.

Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling Pathway.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by augmented type I interferon signaling. High-throughput technologies have identified plenty of SLE susceptibility single-nucleotide polymorphisms (SNPs) yet the exact roles of most of them are still unknown. Functional studies are principally focused on SNPs in the coding regions, with limited attention paid to the SNPs in non-coding regions.

Study on the preparation and flame retardant properties of an eco-friendly potassium-calcium carrageenan fiber.

Potassium-calcium carrageenan fibers were prepared in an eco-friendly fashion by wet spinning method. The forming process and flame retardant properties of this fiber compared with the traditional barium carrageenan fibers were studied in this paper. The results showed that the potassium ions were combined with the sulfate group in the carrageenan by ion bonding that made the potassium-calcium carrageenan fibers form a gel structure, which was a relative loose spatial network, while barium ions reacted with the sulfate groups of carrageenan to induce barium carrageenan fibers form a precipitated structure, which was a relative close spatial network.

Effect of SiO nanoparticle on the physical and chemical properties of eco-friendly agar/sodium alginate nanocomposite film.

Agar/sodium alginate (AG/SA) nanocomposite films were prepared using solution casting method in presence of various concentrations of nano-SiO (2.5, 5, 7.5, and 10 wt%).

Preparation of carrageenan fibers with extraction of Chondrus via wet spinning process.

Traditionally, the carrageenan fibers were prepared by process of extracting, drying, dissolving of carrageenan power and wet spinning process of fibers. However, in this study, carrageenan fibers were prepared by carrageenan solution directly from the extraction of Chondrus, without the steps of precipitation, and drying. The properties of carrageenan powder, spinning solution and carrageenan fibers were characterized with zeta potential, NMR, FTIR, dynamic light scattering (DLS), SEM, tensile testing and energy dispersive spectrometer (EDS).

Preparation and properties of wet-spun agar fibers.

Motivated by the extensive application of agar, this work developed a wet-spinning process to fabricate micro-scale fibers using the gelation process of agar. The effect of three vital spinning parameters, namely dope concentration, coagulation bath composition, and fiber post-processing on morphological properties, tensile properties and chemical structure of the fiber have been discussed. The concentration of agar was determined by the results of rheological measurement.

T-betCD11c B cells are critical for antichromatin immunoglobulin G production in the development of lupus.

Background: A hallmark of systemic lupus erythematosus is high titers of circulating autoantibodies. Recently, a novel CD11c B-cell subset has been identified that is critical for the development of autoimmunity. However, the role of CD11c B cells in the development of lupus is unclear.