Treatment of saccular wide-neck intracranial aneurysm using Leo baby stent: a single-center experience based on 156 cases.

To describe the mid-term safety and efficacy of Leo baby stent applied in saccular wide-neck intracranial aneurysms (IAs). 151 patients harboring 156 IAs treated with Leo baby stent from March 2021 to October 2023 were enrolled for further analysis. Among 156 IAs, 142 cases (91.

Polyoxotungstate Featuring Zinc-Ion-Triggered Structural Transformation as An Efficient Electrolyte Additive for Aqueous Zinc-Ion Batteries.

It is promising but still challenging for the widespread application of aqueous zinc batteries due to the poor reversibility of the zinc anode caused by prevalent dendrite growth and pronounced interfacial side reactions. Herein, we report a rare soluble and water-stable high-nuclearity {NdSiW} polyoxotungstate. Interestingly, upon encountering Zn ions, the discrete {NdSiW} nanocluster undergoes a structural transformation to form an infinitely extended cluster-based {[Zn(HO)][NdSiW]} two-dimensional honeycomb layer, with which atomic-level Zn ion effects in reconstructing the layer are determined.

Boosting multi-carbon products selectivity of carbon dioxide reduction via bifunctional cyclodextrin-modification on copper/copper(I) oxide electrocatalysts.

Electrochemical carbon dioxide reduction to multi-carbon (C) products presents a significant opportunity for converting greenhouse gases into valuable fuels and feedstocks. The development of highly active and stable catalysts remains a critical challenge. In this study, we report the design and synthesis of cyclodextrin-modified Cu/CuO electrocatalysts, which exhibit remarkable efficiency in driving the CO electroreduction process towards C products.

The emerging hybrid electrochemical energy technologies.

Electrochemical energy devices serve as a vital link in the mutual conversion between chemical energy and electrical energy. This role positions them to be essential for achieving high-efficiency utilization and advancement of renewable energy. Electrochemical reactions, including anodic and cathodic reactions, play a crucial role in facilitating the connection between two types of charge carriers: electrons circulating within the external circuit and ions transportation within the internal electrolyte, which ensures the completion of the circuit in electrochemical devices.

Impact of premorbid hypertension and renin-angiotensin-aldosterone system inhibitors on the severity of aneurysmal subarachnoid haemorrhage: a multicentre study.

Background: Hypertension is widely acknowledged as a significant contributory factor to the heightened risk of intracranial aneurysm rupture. Nevertheless, the impact of hypertension management on the outcomes subsequent to aneurysmal subarachnoid haemorrhage (aSAH), particularly concerning the severity of aSAH, remains an underexplored area.

Methods: We conducted a retrospective analysis using data from a prospectively multicentre cohort of 4545 patients with aSAH in China.

Circ_0008571 modulates the phenotype of vascular smooth muscle cells by targeting miR-145-5p in intracranial aneurysms.

Background: The dysfunction of human vascular smooth cells (hVSMCs) is significantly connected to the development of intracranial aneurysms (IAs). By suppressing the activity of microRNAs (miRNAs), circular RNAs (circRNAs) participate in IA pathogenesis. Nevertheless, the role of hsa_circ_0008571 in IAs remains unclear.

A Whole-Process Visible Strategy for the Preparation of Rhizomucor miehei Lipase with Escherichia coli Secretion Expression System and the Immobilization.

Background: Rhizomucor miehei (RM) lipase is a regioselective lipase widely used in food, pharmaceutical and biofuel industries. However, the high cost and low purity of the commercial RM lipase limit its industrial applications. Therefore, it is necessary to develop cost-effective strategies for large-scale preparation of this lipase.

High-Power-Density Rechargeable Hybrid Alkali/Acid Zn-Air Battery Performance Through Value-Added Conversion Charging.

Rechargeable Zn-air batteries (ZABs) are considered highly competitive technologies for meeting the energy demands of the next generation, whether for energy storage or portable power. However, their practical application is hindered by critical challenges such as low voltage, CO poisoning at the cathode, low power density, and poor charging efficiency Herein, a rechargeable hybrid alkali/acid Zn-air battery (h-RZAB) that effectively separates the discharge process in an acidic environment from the charging process in an alkaline environment, utilizing oxygen reduction reaction (ORR) and glycerol oxidation reaction (GOR) respectively is reported. Compared to previously reported ZABs, this proof-of-concept device demonstrates impressive performance, exhibiting a high power density of 562.

Advanced Hollow Cubic FeCo-N-C Cathode Electrocatalyst for Ultrahigh-Power Aluminum-Air Battery.

The exploration of electrocatalysts toward oxygen reduction reaction (ORR) is pivotal in the development of diverse batteries and fuel cells that rely on ORR. Here, a FeCo-N-C electrocatalyst (FeCo-HNC) featuring with atomically dispersed dual metal sites (Fe-Co) and hollow cubic structure is reported, which exhibits high activity for electrocatalysis of ORR in alkaline electrolyte, as evidenced by a half-wave potential of 0.907 V, outperforming that of the commercial Pt/C catalyst.

Nomograms for assessing the rupture risk of anterior choroid artery aneurysms based on clinical, morphological, and hemodynamic features.

Background And Purpose: A notable prevalence of subarachnoid hemorrhage is evident among patients with anterior choroidal artery aneurysms in clinical practice. To evaluate the risk of rupture in unruptured anterior choroidal artery aneurysms, we conducted a comprehensive analysis of risk factors and subsequently developed two nomograms.

Methods: A total of 120 cases of anterior choroidal artery aneurysms (66 unruptured and 54 ruptured) from 4 medical institutions were assessed utilizing computational fluid dynamics (CFD) and digital subtraction angiography (DSA).

RAGE plays key role in diabetic retinopathy: a review.

RAGE is a multiligand receptor for the immunoglobulin superfamily of cell surface molecules and is expressed in Müller cells, vascular endothelial cells, nerve cells and RPE cells of the retina. Diabetic retinopathy (DR) is a multifactorial disease associated with retinal inflammation and vascular abnormalities and is the leading cause of vision loss or impairment in older or working-age adults worldwide. Therapies aimed at reducing the inflammatory response and unnecessary angiogenesis can help slow the progression of DR, which in turn can save patients' vision.

Reference-based genome compression using the longest matched substrings with parallelization consideration.

Background: A large number of researchers have devoted to accelerating the speed of genome sequencing and reducing the cost of genome sequencing for decades, and they have made great strides in both areas, making it easier for researchers to study and analyze genome data. However, how to efficiently store and transmit the vast amount of genome data generated by high-throughput sequencing technologies has become a challenge for data compression researchers. Therefore, the research of genome data compression algorithms to facilitate the efficient representation of genome data has gradually attracted the attention of these researchers.

Applications of Programmable Endonucleases in Sequence- and Ligation-Independent Seamless DNA Assembly.

Programmable endonucleases, such as Cas (Clustered Regularly-Interspaced Short Repeats-associated proteins) and prokaryotic Argonaute (pAgo), depend on base pairing of the target DNA with the guide RNA or DNA to cleave DNA strands. Therefore, they are capable of recognizing and cleaving DNA sequences at virtually any arbitrary site. The present review focuses on the commonly used in vivo and in vitro recombination-based gene cloning methods and the application of programmable endonucleases in these sequence- and ligation-independent DNA assembly methods.

Use of 3D-printing cerebral aneurysm model assisting microcatheter shaping in neurovascular intervention technique training.

Background: Microcatheter shaping plays a vital role in coil embolization of cerebral aneurysms, while the complicated method and insufficient training opportunities make it difficult for junior neurovascular clinicians to master this technique. In this program, we constructed a novel training method and assessment system for microcatheter shaping in coil embolization of cerebral aneurysms with 3D technique, and evaluated its efficacy for microcatheter shaping training in junior neurovascular clinicians.

Methods: Patient-specific models for cerebral aneurysms in different locations and with different morphologies were selected by experienced senior neurovascular clinicians.

Role of Circulating Exosomes in Cerebrovascular Diseases: A Comprehensive Review.

Exosomes are lipid bilayer vesicles that contain multiple macromolecules secreted by the parent cells and play a vital role in intercellular communication. In recent years, the function of exosomes in cerebrovascular diseases (CVDs) has been intensively studied. Herein, we briefly review the current understanding of exosomes in CVDs.

Development of high-efficiency alkaline OER electrodes for hybrid acid-alkali electrolytic H generation.

The development of high-efficiency oxygen evolution reaction (OER) electrocatalysts is of great importance for electrolytic H generation. In this work, we report in-situ growth of MnCoO nanoneedles and NiFeRu layered double hydroxide (LDH) nanosheets on nickel foam (NF) (MnCoO@NiFeRu-LDH/NF) that can function a highly efficient electrode toward electrocatalysis of OER. Such electrode demands an overpotential of as low as 205 mV to reach 10 mA cm in alkaline electrolyte and can run stably over 120-hours continuous operation.

Retreatment with a flow diverter for recurrent blood blister-like aneurysms after embolization: A single-center case series.

Background And Purpose: Treatment of blood blister-like aneurysms (BBAs) has been a significant challenge mainly due to their high recurrence rate even after stent-assisted coiling (SAC) embolization. This study aims to evaluate the safety and efficacy of treating recurrent BBAs after SAC with a flow diverter (FD).

Methods: A retrospective series of patients with recurrent BBAs who underwent the retreatment with the FD from June 2018 to December 2021 was included to analyze perioperative safety and immediate postoperative and follow-up outcomes.

Crack Localization in Operating Rotors Based on Multivariate Higher Order Dynamic Mode Decomposition.

A novel output-only crack localization method is proposed for operating rotors based on an enhanced higher-order dynamic mode decomposition (HODMD), in which the nonlinear breathing crack-induced super-harmonic characteristic components from multiple vibration measurement points are simultaneously extracted to compose the corresponding super-harmonic transmissibility damage indexes. Firstly, the theoretical background of the HODMD is briefly reviewed. Secondly, the proposed crack localization method is dedicated which improving the HODMD for multivariate signals by casting the total least square method into standard HODMD and adaptively selecting the order parameter of Koopman approximation by optimizing the super-harmonic frequency vector.

CMIC: an efficient quality score compressor with random access functionality.

Background: Over the past few decades, the emergence and maturation of new technologies have substantially reduced the cost of genome sequencing. As a result, the amount of genomic data that needs to be stored and transmitted has grown exponentially. For the standard sequencing data format, FASTQ, compression of the quality score is a key and difficult aspect of FASTQ file compression.

Aqueous OH /H Dual-Ion Zn-Based Batteries.

Aqueous Zn-based batteries hold multiple advantages of eco-friendliness, easy accessibility, high safety, easy fabrication, and fast kinetics, while their widespread applications have been greatly limited by the relatively narrow thermodynamically stable potential windows (i. e., 1.

Effect of Renin-Angiotensin-Aldosterone System Inhibitors on the Rupture Risk Among Hypertensive Patients With Intracranial Aneurysms.

Background: Mounting experimental evidence supports the concept that the RAAS (renin-angiotensin-aldosterone system) is involved in the pathogenesis of intracranial aneurysm rupture. However, whether RAAS inhibitors could reduce the rupture risk of intracranial aneurysms remains unclear.

Methods: We performed a chart review of a multicenter, prospectively maintained database of 3044 hypertensive patients with intracranial aneurysms from 20 medical centers in China.

Effect of Proximal Parent Artery Stenosis on the Outcomes of Posterior Communicating Artery Aneurysms: A Preliminary Study Based on Case-Specific Hemodynamic Analysis.

Objective: The objective of the study was to evaluate the effect of proximal parent artery stenosis on the hemodynamics of aneurysms in the internal carotid artery-posterior communicating artery (ICA-Pcom).

Methods: A retrospective study of 74 patients with aneurysms in the ICA-Pcom who underwent treatment at the Department of Neurosurgery of Changhai Hospital was conducted between January and June 2018. Patients with proximal parent artery stenosis were included.

The 8-year single-center experience of telescoping flow diverter for complex intracranial aneurysms treatment.

Objective: Treatment of complex intracranial aneurysms (IAs) is still a challenging thing and this study aims to summarize the experience of telescoping flow diverters (FDs) in treating complex intracranial aneurysms.

Method: Between April 2013 to November 2020, 381 IA cases treated by flow diverters (FD) were retrieved from the database of 4988 IA cases, and finally 20 cases treated by telescoping FDs were enrolled for further analysis.

Result: Among 20 patients, 15 patients (75.

Association Between Regular Blood Pressure Monitoring and the Risk of Intracranial Aneurysm Rupture: a Multicenter Retrospective Study with Propensity Score Matching.

Although hypertension is a known risk factor for intracranial aneurysm rupture, the benefit of the management of blood pressure in reducing the rupture risk of intracranial aneurysms remains largely unknown, especially for regular blood pressure monitoring. We conducted a retrospective analysis of a prospectively maintained database of 3965 patients with saccular intracranial aneurysms from 20 medical centers in China. The patients were divided into the non-hypertensive group and hypertensive group.