Trivalent recombinant protein vaccine induces cross-neutralization against XBB lineage and JN.1 subvariants: preclinical and phase 1 clinical trials.

The immune escape capacities of XBB variants necessitate the authorization of vaccines with these antigens. In this study, we produce three recombinant trimeric proteins from the RBD sequences of Delta, BA.5, and XBB.

RUNX2 enhances bladder cancer progression by promoting glutamine metabolism.

Bladder cancer is a prevalent malignancy within the urinary system. Prior research has suggested that glutamine metabolism plays a crucial role in driving bladder cancer progression. However, the precise molecular mechanism governing glutamine metabolism in bladder cancer is still inadequately understood.

Mechanistic insights into carbonate radical-driven reactions: Selectivity and the hydrogen atom abstraction route.

Carbonate radical (CO) is inevitably produced in advanced oxidation processes (AOPs) when addressing real-world aqueous environments, yet it often goes unnoticed due to its relatively lower reactivity. In this study, we emphasized the pivotal role of CO in targeting the elimination of contaminants by contrasting it with conventional reactive oxygen species (ROSs) and assessing the removal of sulfamethazine (SMT). Similar to singlet oxygen (O), CO shows a preference for electron-rich organic compounds.

Transcriptome Analysis Reveals the Molecular Mechanisms of Carrot Adaptation to Alternaria Leaf Blight.

Carrot ( L.) is an important vegetable crop that is rich in carotenoids and is widely cultivated throughout the world. Alternaria leaf blight (ALB), caused by infection with (), is the most serious fungal disease in carrot production.

The synergistic effect of radical and non-radical processes on the dephosphorization of dimethoate by vacuum ultraviolet: The overlooked roles of singlet oxygen atom and high-energy excited state.

Organophosphorus pesticides are extensively utilized worldwide, but their incomplete dephosphorization poses significant environmental risks. This study investigates the dephosphorization of dimethoate (DMT), a representative organophosphorus pesticide, using a vacuum ultraviolet system. Surprisingly, in addition to hydroxyl radicals (OH), non-radical processes such as photoexcitation and singlet oxygen atoms (O(D)) exert more significant effects on DMT dephosphorization.

Diversity and Functional Roles of Root-Associated Endophytic Fungi in Two Dominant Pioneer Trees Reclaimed from a Metal Mine Slag Heap in Southwest China.

The utilization of fast-growing, economically valuable woody plants with strong stress resistance, such as poplar and willow, to revegetate severely metal-contaminated mine tailings not only offers a productive and profitable use of abandoned polluted soil resources but also facilitates the phytoremediation of these polluted soils. This study examines the diversity and functional roles of endophytic fungi naturally colonizing the roots of an artificially established forest and the naturally reclaimed pioneer species on an abandoned tailing dam in southwest China. Culture-independent analyses revealed that the root systems of both plant species were abundantly colonized by arbuscular mycorrhizal fungi and endophytic fungi, forming rich and diverse endophytic fungal communities predominantly represented by the genera , , , and unclassified members of Helotiales.

Exploring action-law of microplastic abundance variation in river waters at coastal regions of China based on machine learning prediction.

Surface waters, particularly the river systems, constitute a vital freshwater resource for human beings and aquatic life on Earth. In economically developed and densely populated coastal regions, river water is facing severe microplastic pollution, posing a threat to public health and ecological safety. Reliable prediction of microplastic abundance (MPA) can significantly reduce the costs associated with microplastic field sampling and analysis.

Assessment of left atrial function and left atrioventricular coupling via cardiac magnetic resonance in individuals with prediabetes and diabetes.

Aims: Assessment of left atrial (LA) function and the left atrioventricular coupling index (LACI) have recently been increasingly recognized as important indices for cardiovascular diseases associated with the presence of prediabetes and diabetes. We aimed to evaluate LA function and the LACI in patients with prediabetes and diabetes via cardiac magnetic resonance (CMR).

Methods: In this retrospective study, we included 35 patients with prediabetes, 32 patients with diabetes, and 84 healthy control participants.

Contrast-enhanced ultrasound findings of sclerotic nodules in Wilson disease: A case report.

Rationale: Wilson disease is an autosomal recessive genetic disease found by Samuel Alexander Kinnier Wilson and prevalent in childhood and adolescents.

Patient Concerns: An 18-year-old female patient presented to our hospital with a continuous decrease of 3 blood cell lines for more than 10 days, and diagnosed as decompensated cirrhosis. Ultrasonography showed diffuse lesions in the hepatic parenchyma, with multiple hypoechoic light masses in the parenchyma, the outline was still clear, and the internal echo was uneven.

Molecular Unravelling of the Structural Effect of Quinone Redox Mediators on Oxygen Reduction Reaction in Aprotic Lithium-Oxygen Batteries.

Redox mediators (RMs) provide tantalizing solutions to unlock the energy capabilities of aprotic lithium-oxygen (Li-O) batteries by driving solution-mediated LiO growth. However, the structural effect of RMs on the catalytic efficiency of the oxygen reduction reaction remains incompletely understood. Herein, we present the interplay between the structure of RMs and their discharge capabilities by a comparative study of model quinone (Q)-based RMs.

Advancements in therapeutic peptides: Shaping the future of cancer treatment.

In the evolving landscape of cancer treatment, therapeutic peptides are assuming to play an increasingly vital role. Although the number of peptide drugs available for clinical cancer treatment is currently limited, extensive preclinical research is underway, presenting a promising trajectory for the future. The collaborative efforts of natural anti-cancer peptides (ACPs) and synthetic ACPs, propelled by advancements in molecular biology and peptide chemistry, are steering remarkable progress in this domain.

Synergistically enhanced heterogeneous activation of dissolved oxygen for aqueous carbamazepine degradation over S(III) coupled with siderite.

The wide occurrence of emerging contaminants (ECs) was drawing more attention due to the potential hazard and threat on human and environment. Carbamazepine (CBZ) is a widely prescribed medication that has garnered considerable research interest with the exposures exceeding the environmental carrying capacity. We have established the innovative heterogeneous advanced oxidation process (AOPs) based on the activated dissolved oxygen (DO) coupled with S(III) and natural iron ore (siderite).

Development and validation of a nomogram to predict severe influenza.

Background: Influenza is an acute respiratory disease posing significant harm to human health. Early prediction and intervention in patients at risk of developing severe influenza can significantly decrease mortality.

Method: A comprehensive analysis of 146 patients with influenza was conducted using the Gene Expression Omnibus (GEO) database.

Mechanistic Study on Oxygen Reduction Reaction in High-Concentrated Electrolytes for Aprotic Lithium-Oxygen Batteries.

Highly concentrated electrolytes (HCEs) have energized the development of high-energy-density lithium metal batteries by facilitating the formation of robust inorganic-derived solid electrolyte interfaces on the lithium anode. However, the oxygen reduction reaction (ORR) occurring on the cathode side remains ambiguous in HCE-based lithium-oxygen (Li-O) batteries. Herein, we investigate the ORR mechanism in a highly concentrated LiTFSI-CHCN electrolyte using ultra-microelectrode voltammetry coupled with in situ spectroscopies.

Electron Sponge Effect by Dynamic-Regulated Electron Self-Flow toward Coupled Electrochemical Ammonia Synthesis.

A dynamic-regulated Pd-Fe-N electrocatalyst was effectively constructed with electron-donating and back-donating effects, which serves as an efficient engineering strategy to optimize the electrocatalytic activity. The designed PdFe/FeN features a comprehensive electrocatalytic performance toward the nitrogen reduction reaction (NRR, yield rate of 29.94 μg h mg and FE of 38.

The value analysis of high-resolution thin-layer CT in the identification of early lung adenocarcinoma: An observation study.

The aim of this study was to explore the clinical value of high-resolution thin-layer computed tomography (CT) for the identification of early lung adenocarcinoma. Ninety patients with early lung adenocarcinoma who were diagnosed and treated in our hospital were selected as study subjects and divided into noninvasive (NIG, n = 51) and invasive (IG, n = 39) groups according to their pathological findings. Both groups underwent high-resolution target scanning.

Mathematical models for traffic-source PM dispersion in an urban street canyon considering the capture capability of roadside trees.

Rapid urbanization increases the densely built-up blocks, the population and vehicles. Large amounts of particulate matter (PM), especially PM (PM with an aerodynamic diameter of 2.5μm or less), from vehicle exhaust are critical to human health.

High-Electrochemical-Activity Composite Cathode Enabled by Fast Segmental Relaxation for Solid-State Lithium-Sulfur Batteries.

Solid-state lithium-sulfur batteries (SSLSBs) have attracted a great deal of attention because of their high theoretical energy density and intrinsic safety. However, their practical applications are severely impeded by slow redox kinetics and poor cycling stability. Herein, we revealed the detrimental effect of aggregation of lithium polysulfides (LiPSs) on the redox kinetics and reversibility of SSLSBs.

Betahistine mesylate reduces the damage of blue light exposure in Drosophila model.

Previous studies have demonstrated the efficacy of betahistine mesylate in treating vertigo and angioneurotic headache, enhancing microcirculation, and facilitating histamine release. However, limited research has been conducted on the drug's potential in mitigating blue light-induced damage. Thus, this study utilized Drosophila as the model organism and employed the Siler model to investigate the impact of various concentrations of betahistine mesylate on the lifespan, under 3000 lx blue light irradiation.

Rational Design of a Multifunctional Hydrogel Trap for Water and Fertilizer Capture: A Review.

Water scarcity and land infertility pose significant challenges to agricultural development, particularly in arid and semiarid regions. Improving soil-water-retention capacity and fertilizer utilization efficiency through the application of soil additives has become a pivotal approach in agricultural practices. Hydrogels exhibit exceptional water absorption and fertilizer retention capabilities, making them extensively utilized in the fields of agriculture, forestry, and desert control.

Pre-diagnostic plasma advanced glycation end-products and soluble receptor for advanced glycation end-products and mortality in colorectal cancer patients.

Advanced glycation end-products (AGEs), formed endogenously or obtained exogenously from diet, may contribute to chronic inflammation, intracellular signaling alterations, and pathogenesis of several chronic diseases including colorectal cancer (CRC). However, the role of AGEs in CRC survival is less known. The associations of pre-diagnostic circulating AGEs and their soluble receptor (sRAGE) with CRC-specific and overall mortality were estimated using multivariable-adjusted Cox proportional hazards regression among 1369 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.