SUMO1 modification reduces oxidative stress and SUMO1ylated AKAP4 degradation affects frozen-thawed boar sperm quality.

Low-temperature injury affects normal physiological function and viability of boar sperm during cryopreservation. Small ubiquitin-like modifier (SUMO) modification of proteins after translation is related to the cell stress response but the relationship between SUMO modification and oxidative stress in freeze-thawed sperm remains unclear. A-kinase ankyrin 4 (AKAP4) and its precursor proAKAP4 are two main proteins in mammalian sperm.

Cep78 knockout causes sterility and oligoasthenoteratozoospermia in male mice.

Oligoasthenoteratozoospermia (OAT) is a common cause of infertility among males, and the majority of cases of idiopathic OAT are thought to be attributed to genetic defects. In this study, the role of the CEP78 protein in spermatogenesis was initially investigated using Cep78 knockout (Cep78) mice. Notably, the male Cep78 mice exhibited the OAT phenotype and sterility.

Dispersion Forces-Driven Hierarchical Assembly of Protein-Like Lanthanide Octamers and Emergent CPL.

Hierarchical self-assembly driven by non-covalent interactions is a prevalent strategy employed by nature to construct sophisticated biomacromolecules, such as proteins. However, the construction of protein-like superstructures that rely on weaker dispersion forces-driven hierarchical assembly remains largely unexplored. Here, we report the first example of dispersion forces driving the high-order assembly of the lanthanide trinuclear circular helicate [HNEt₃]₃[Eu₃(L)₆] (ΔΔΔ-1) into a protein-like lanthanide octamer ((ΔΔΔ-1)₈-2).

An insight into the causal relationship between sarcopenia-related traits and venous thromboembolism: A mendelian randomization study.

Background: As a geriatric syndrome, sarcopenia has a high prevalence in the old population and represents an impaired state of health with adverse health outcomes. A strong clinical interest in its relationship with venous thromboembolism (VTE), which is a complex trait disease with a heterogeneous annual incidence rate in different countries, has emerged. The relationship between sarcopenia and venous thromboembolism has been reported in observational studies but the causality from sarcopenia to VTE remained unclarified.

Novel use of structural equation modeling to examine the development of a framework of patient-centered two-way referral systems for building digital subjective well-being healthcare: A cross-sectional survey in Central China.

Background: Digital health technologies are progressively assuming significant roles in aspects encompassing in-hospital management, patient-centered design, and tiered referral systems. Nevertheless, current studies do not involve exploration into the potential value and mechanisms of digital health in a patient-centered context. This study aimed to explore the development of a framework of comprehensive, evidence-based digital health technologies for the construction of welfare-oriented healthcare.

FDA-Approved Tedizolid Phosphate Prevents Cisplatin-Induced Hearing Loss Without Decreasing Its Anti-tumor Effect.

Purpose: Cisplatin is a low-cost clinical anti-tumor drug widely used to treat solid tumors. However, its use could damage cochlear hair cells, leading to irreversible hearing loss. Currently, there appears one drug approved in clinic only used for reducing ototoxicity associated with cisplatin in pediatric patients, which needs to further explore other candidate drugs.

Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis.

Background: Autoimmune thyroid disease (AITD) ranks among the most prevalent thyroid diseases, with inflammatory cytokines playing a decisive role in its pathophysiological process. However, the causal relationship between the inflammatory cytokines and AITD remains elusive.

Methods: A two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal connection between AITD and 41 inflammatory cytokines.

Stable Perovskite Quantum Dots Light-Emitting Diodes with Efficiency Exceeding 24.

Perovskite nanocrystals for light-emitting diodes are often synthesized by uncontrollable metathesis reactions, suffering from low product yield, nonuniform growth, and poor stability. Herein, by controlling the nucleation kinetics with high dissociation constant (Ka or Kb) acids or bases, homogenous one-route nucleation of perovskite nanocrystals is achieved as the cluster intermediates are eliminated. The stable, shape uniform, and narrow size distribution green nanocrystals are synthesized.

Interesting influence of AlO on the catalytic stability of CoP, MoP and CoMoP catalysts for dry reforming of methane.

Interestingly, the metal-support interaction (MSI) influence of different metal phosphides on catalytic stability might be different in dry reforming of methane (DRM). After being supported on AlO, there was a rise, decline and no change in the catalytic stability of CoMoP, MoP and CoP, respectively. This was probably because the MSI can tune the structural stability, methane dissociation ability and oxidation resistance ability of metal phosphides, which were the key factors that determined their catalytic stability.

Effect of megarectum on postoperative defecation of female patients with congenital rectovestibular fistula or rectoperineal fistula.

Background: To assess the effect of megarectum on postoperative defecation of female patients with congenital rectovestibular fistula or rectoperineal fistula.

Methods: From March 2013 to February 2021, 74 female patients with congenital rectovestibular fistula or rectoperineal fistula were treated. The age of patients ranged from 3 months to 1 year.

A novel lnc-LAMC2-1:1 SNP promotes colon adenocarcinoma progression by targeting miR-216a-3p/HMGB3.

Single nucleotide polymorphisms (SNPs) was associated with altering the secondary structure of long non-coding RNA (lncRNA). Increasing reports showed that played an important role in cancer development and invasion. This study is to elucidate the molecular function of promoting tumor progression in colon adenocarcinoma (COAD).

Circularly Polarized Luminescent Eu() Cage for Enantiomeric Excess and Concentration Simultaneous Determination of Chiral Diamines.

Undoubtably, it is challenging to simultaneously determine the identity, enantiomeric excess (ee), and total concentration of an enantiomer by just one optical measurement. Herein, we design a chiral tetrahedron Eu() with circularly polarized luminescence (CPL), which presents highly selective/stereoselective, rapid, and "turn-on" CPL response to chiral diamines, rather than the monoamino compounds, such as monoamines or amino alcohols. By recording the left- and right-CPL intensities of the Eu ion at 591 nm, the enantiomeric composition and concentration of chiral diamines can be simultaneously determined by monitoring the value and total emission intensity ( + ), respectively.

Computational study on new natural compound inhibitors of Traf2 and Nck-interacting kinase (TNIK).

Traf2 and Nck-interacting kinase (TNIK) is the downstream molecule of Wnt/β-catenin signal pathway. As the activation kinase of β-catenin/T-cell factor 4 transcription complex, it can fully activate Wnt signalling and promote the growth and invasion of tumor cells. We conducted computer-assisted virtual screening and a series of analyses to find potential inhibitors of TNIK.

Dioscin ameliorates slow transit constipation in mice by up-regulation of the BMP2 secreted by muscularis macrophages.

Objectives: The loss of enteric neurons has been shown to be a major cause of slow transit constipation (STC). Gut microbiota and muscularis macrophages (MMs) are associated with the enteric nervous system (ENS) development and gastrointestinal (GI) motility. This study aimed to investigate whether Dioscin (DIO) increased GI motility and inhibited neuron loss by modulating gut microbiota profile, improving inflammation in the ENS microenvironment.

Asymmetric induction in quadruple-stranded europium(III) helicates and circularly polarized luminescence.

Chiral supramolecular lanthanide-helicates are regarded as promising chiroptical materials due to their combination of ground and excited state chirality and special luminescence properties from Ln, named circularly polarized luminescence (CPL). However, the sophisticated and costly asymmetric syntheses decelerate their research progress. Herein, a chiral induction strategy is employed to break the racemic equilibrium of lanthanide helicate by the formation of a compact ion pair.

Based on Network Pharmacology and Gut Microbiota Analysis to Investigate the Mechanism of the Laxative Effect of Pterostilbene on Loperamide-Induced Slow Transit Constipation in Mice.

Pterostilbene (PTE) is a natural polyphenol compound that has been proven to improve intestinal inflammation, but its laxative effect on slow transit constipation (STC) has never been studied. This study aims to investigate the laxative effect of PTE on loperamide (LOP)-induced STC mice and its influence on intestinal microbes through a combination of network pharmacological analysis and experimental verification. PTE was used to treat LOP-exposed mice, and the laxative effect of PTE was evaluated by the total intestinal transit time and stool parameters.

Ancillary ligand modulated stereoselective self-assembly of triple-stranded Eu(iii) helicate featuring circularly polarized luminescence.

Creating optically pure metal assemblies is a hot research topic in the realms of chiral supramolecules. Here, three new triple-stranded europium(iii) helicates EuL(L') [L = 4,4'-bis(4,4,4-trifluoro-1,3-dioxobutyl)diphenyl sulphide; L' = 1,10-phenanthroline (Phen) or /-2,2'-bis(diphenylphosphinyl)-1,1'-binaphthyl (/-BINAPO)] were synthesized in order to investigate the effects of ancillary ligands on controlling the stereoselective self-assembly of lanthanide helicates. X-ray single crystal structure analysis showed that EuL(Phen) crystalized in an achiral space group 1̄ with the equivalent amount of P and M helicates in one single cell.

Al18F-NOTA-FAPI-04 Outperforms 18F-FDG PET/CT in Identifying the Primary Lesion and Rare Metastases From Gastric Cancer.

A 45-year-old woman with gastric cancer underwent FDG PET/CT for initial staging. However, the primary and the metastatic lesions were observed with low or no FDG uptake. Then, the patient underwent fibroblast-activated protein inhibitor PET/CT 2 days later, which demonstrated more lesions and much higher tumor-to-background contrast than FDG PET/CT did.

Nickel clusters accelerating hierarchical zinc indium sulfide nanoflowers for unprecedented visible-light hydrogen production.

As a typical two-dimensional (2D) metal chalcogenides and visible-light responsive semiconductor, zinc indium sulfide (ZnInS) has attracted much attention in photocatalysis. However, the high recombination rate of photogenerated electrons and holes seriously limits its performance for hydrogen production. In this work, we report in-situ photodeposition of Ni clusters in hierarchical ZnInS nanoflowers (Ni/ZnInS) to achieve unprecedented photocatalytic hydrogen production.

Hepatic Lesion of Mucosa-Associated Lymphoid Tissue Lymphoma Revealed by Al18F-NOTA-FAPI-04 PET/CT.

A middle-aged man was newly diagnosed with mucosa-associated lymphoid tissue lymphoma with secondary liver involvement. The hepatic lesion was not shown on FDG PET/CT but FAPI (fibroblast-activated protein inhibitor) PET/CT, which revealed abnormal FAPI accumulation. This case demonstrated that FAPI PET/CT might provide value in hepatic mucosa-associated lymphoid tissue lymphoma.

Perovskite Quantum Dots with Ultralow Trap Density by Acid Etching-Driven Ligand Exchange for High Luminance and Stable Pure-Blue Light-Emitting Diodes.

The research on metal halide perovskite light-emitting diodes (PeLEDs) with green and infrared emission has demonstrated significant progress in achieving higher functional performance. However, the realization of stable pure-blue (≈470 nm wavelength) PeLEDs with increased brightness and efficiency still constitutes a considerable challenge. Here, a novel acid etching-driven ligand exchange strategy is devised for achieving pure-blue emitting small-sized (≈4 nm) CsPbBr perovskite quantum dots (QDs) with ultralow trap density and excellent stability.

4,5-Dioxo-imidazolinium Cation Activation of 1-Acyl-1-carbamoyl Oximes: Access to Cyanoformamides Using Dichloroimidazolidinedione.

Cyanoformamides are prevalent as versatile building blocks for accessing synthetically useful intermediates and biologically active compounds. The development of a milder, simpler, and more efficient approach to cyanoformamides is nontrivial. Herein, we demonstrate the effectiveness of 4,5-dioxo-imidazolinium cation activation for transforming 1-acyl-1-carbamoyl oximes to cyanoformamides.

Novel synthesis of a NiMoP phosphide catalyst in a CH-CO gas mixture.

NiMo bimetallic phosphide was synthesized from its corresponding oxidic precursor in a 1 : 1 CH : CO gas mixture for the first time. The in situ synthesized NiMoP phase in the feed for CH-CO reforming can exhibit a higher activity compared to the one prepared in H.