Effect of nitrogen levels on grain yield and quality in improving mid-season japonica rice varieties.

Background: Nitrogen application is recognized as a principal factor influencing rice quality. However, there remains a paucity of research on the effects of different N levels on quality, particularly within the context of the improvement of rice varieties.

Results: This study examined 14 mid-season japonica rice varieties cultivated in Jiangsu province over the past 80 years under five N application levels (0, 90, 180, 270, and 360 kg N ha).

Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal malignancy characterized by dysregulated energy and stromal metabolism. It is strongly supported by activated pancreatic stellate cells (PSC) which drive excessive desmoplasia and tumor growth via metabolic crosstalk. Herein, a programmed nanosystem is designed to dual rectify the metabolism abnormalities of the PDAC cells, which overexpress glucose transporter 1(GLUT1) and CD71, and the PSC for oncotherapy.

Deciphering the Effects of Phosphate Fertiliser on Rhizospheric Bacterial Community Structure and Potato Common Scab.

The prolonged practice of continuous potato cropping, coupled with inadequate field management, disrupts the soil bacterial community equilibrium. Such disturbances compromise the resilience of the soil ecosystem, predisposing it to an increased incidence of potato diseases. However, the effects of the phosphorus fertiliser application rate on the rhizosphere soil bacterial community composition of potatoes and the occurrence of potato common scab (CS) have not been adequately studied.

Short term efficacy and safety of PD-1 inhibitor and apatinib plus S-1 and oxaliplatin as neoadjuvant chemotherapy for patients with locally advanced gastric cancer.

Surgical resection is the cornerstone of treatment for locally advanced gastric cancer (LAGC). Hence, downstaging of the tumor with neoadjuvant therapy is critical for R0 resection and prolongs the overall survival. Data from related studies are lacking, and the literature is scarce.

Dynamic covalent bonds enabled recyclable chitosan oligosaccharide-based wood adhesive with high adhesion and anti-mildew performances.

Biomass wood adhesives have emerged as a promising alternative to traditional synthetic resins due to their ability to address issues related to formaldehyde pollution and reliance on petrochemical resources. However, these adhesives are generally not recyclable and require high curing temperatures. Herein, a novel eco-friendly, strong, and recyclable chitosan oligosaccharide (CS)-based wood adhesive named CS-PB was developed using CS, lignin-derived 3,4-dihydroxybenzaldehyde, and 1,4-phenylenediboronic acid.

A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study.

Objectives: The objective of this study was to profile the transcriptional profiles of peripheral blood mononuclear cells (PBMCs) and their immune repertoires affected by anti-synthetase syndrome (ASS) at the single-cell level.

Methods: We performed single-cell RNA sequencing (scRNA-seq) analysis of PBMCs and bulk RNA sequencing for patients with ASS (N=3) and patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 DM, N=3) along with healthy controls (HCs, N=4). As ASS and MDA5 DM have similar organ involvements, MDA5 DM was used as a disease control.

Morphology, phylogeny, and mitogenomics reveal a new entomopathogenic fungus, (Hypocreales, Clavicipitaceae), from southwestern China.

Two species of (Clavicipitaceae, Hypocreales, Ascomycota) were discovered during an investigation of the diversity of entomopathogenic fungi. A new fungus and one known fungal species that were gathered from Yunnan Province were described in this study. , sp.

Modulation of Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus by Sphingomonas Sp Y503 via the CrMAPKKK1-CrMAPKK1/CrMAPKK2-CrMPK3 Signaling Cascade.

Catharanthus roseus is a highly relevant model for investigating plant defense mechanisms and the biosynthesis of therapeutically valuable compounds, including terpenoid indole alkaloids (TIAs). It has been demonstrated that beneficial microbial interactions can regulate TIA biosynthesis in C. roseus, highlighting the need to fully comprehend the molecular mechanisms involved to efficiently implement eco-friendly strategies.

Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study.

Background: Myelodysplastic syndrome (MDS) is a complicated hematopoietic malignancy characterized by bone marrow (BM) dysplasia with symptoms like anemia, neutropenia, or thrombocytopenia. MDS exhibits considerable heterogeneity in prognosis, with approximately 30% of patients progressing to acute myeloid leukemia (AML). Single cell RNA-sequencing (scRNA-seq) is a new and powerful technique to profile disease landscapes.

Multi-locus molecular phylogenetic analysis reveals two new species of (Bionectriaceae, Hypocreales).

has been previously accepted as a member of the Cordycipitaceae and currently it is considered a member of the Bionectriaceae. The substrates of were complex and varied, being mainly animal faeces. This study reports two new species of from Yunnan Province in south-western China.

Global, regional, and national burdens of atopic dermatitis under 14: a trend analysis and future prediction based on the global burden of disease study 2019.

Objective: The aim is to evaluate the global, regional, and national trends in the burden of children and adolescents under 14 from 1990 to 2019, as well as future trend predictions.

Methods: In Global Burden of Disease (GBD), we reported the incidence, prevalence rate and the years lived with disability (YLDs), the incidence per 100,000 people, and the average annual percentage change (AAPC). We further analyzed these global trends by age, gender, and social development index (SDI).

Morphological and Phylogenetic Analyses Reveal Three New Species of Entomopathogenic Fungi Belonging to Clavicipitaceae (Hypocreales, Ascomycota).

This study aims to report three new species of and from Yunnan Province, Southwestern China. Species of and parasitize scale insects (Coccidae and Lecaniidae, Hemiptera) and whiteflies (Aleyrodidae, Hemiptera). Based on the phylogenetic analyses of the three-gene nrLSU, , and , it showed one new record species () and one new species ( sp.

Artificial intelligence-based perioperative safety verification system improved the performance of surgical safety verification execution.

Objective: To explore the application effect of the artificial intelligence-based (AI-based) perioperative safety verification system in the performance of safety verification execution in urological and general surgeries.

Methods: The surgical checklists of 141 urological and general surgical patients from September to December 2019 in Hangzhou Children's Hospital were selected as the control group, and 71 surgical checklists for urological and general surgeries that the applied AI-based perioperative safety verification system from August to September 2022 were chosen as the experimental group. We compared the execution rate and standardization rate of safety verification as well as the satisfaction of surgeons, nurses, and anesthesiologists between the two groups.

Exogenous Spermidine and Amino-Ethoxyvinylglycine Improve Nutritional Quality via Increasing Amino Acids in Rice Grains.

Polyamines and ethylene are key regulators of the growth and development, quality formation, and stress response of cereal crops such as rice. However, it remains unclear whether the application of these regulators could improve the nutritional quality via increasing amino acids in rice grains. This study examined the role of exogenous polyamines and ethylene in regulating amino acid levels in the milled rice of earlier-flowered superior grain (SG) and later-flowered inferior grain (IG).

Species diversity and major host/substrate associations of the genus (Hypocreales, Cordycipitaceae).

, a group of fungi with rich morphological and ecological diversity in Cordycipitaceae (Ascomycota, Hypocreales), has a wide distribution amongst diverse habitats. By surveying arthropod-pathogenic fungi in China and Southeast Asia over the last six years, nine spp. were found and identified.

Genomic Comparison of Two Species of with Other Genera in the Family Cordycipitaceae.

Whole genomes of ICMM 82-2 and YFCC 1527 were sequenced and annotated, as well as compared with whole genome sequences of other species in the family Cordycipitaceae. ICMM 82-2, FENG and YFCC 1527 had 54, 57 and 58 putative secondary metabolite biosynthetic gene clusters, respectively. had one unique domain and YFCC 1527 six.

Involvement of brassinosteroids and abscisic acid in spikelet degeneration in rice under soil drying during meiosis.

Spikelet degeneration in rice (Oryza sativa L.) is a serious physiological defect, and can be regulated by soil moisture status and phytohormones. This study investigated the possibility that brassinosteroids (BRs) in collaboration with abscisic acid (ABA) are involved in mediating the effect of soil drying during meiosis on spikelet degeneration in rice.

Morphology, phylogeny and host specificity of two new species belonging to the "zombie-ant fungi" clade (Ophiocordycipitaceae, Hypocreales).

Species of the genus , which include species able to manipulate the behaviour of ants, are known as the "zombie-ant fungi" and have attracted much attention over the last decade. They are widespread within tropical, subtropical and even temperate forests worldwide, with relatively few reports from subtropical monsoon evergreen broad-leaved forest. Fungal specimens have been collected from China, occurring on ants and producing hirsutella-like anamorphs.

Phylogeny and species delimitations in the economically, medically, and ecologically important genus (Cordycipitaceae, Hypocreales).

is a ubiquitous genus of cosmopolitan arthropod-pathogenic fungi in the family Cordycipitaceae. The fungi have economic, medicinal, and ecological importance. Prior taxonomic studies of these fungi relied predominantly on phylogenetic inferences from five loci, namely, the nuclear ribosomal small and large subunits (nr SSU and nr LSU), the 3' portion of translation elongation factor 1 alpha (3P_), and RNA polymerase II subunits 1 and 2 ( and ).

Hepatotoxicity assessment investigations on PFASs targeting L-FABP using binding affinity data and machine learning-based QSAR model.

Per- and polyfluoroalkyl substances (PFASs) are persistent organic pollutants that have been detected in various environmental media and human serum, but their safety assessment remains challenging. PFASs may accumulate in liver tissues and cause hepatotoxicity by binding to liver fatty acid binding protein (L-FABP). Therefore, evaluating the binding affinity of PFASs to L-FABP is crucial in assessing the potential hepatotoxic effects.