The Expression Profile of Genes Related to Carotenoid Biosynthesis in Pepper Under Abiotic Stress Reveals a Positive Correlation with Plant Tolerance.

In light of the increasingly adverse environmental conditions and the concomitant challenges to the survival of important crops, there is a pressing need to enhance the resilience of pepper seedlings to extreme weather. Carotenoid plays an important role in plants' resistance to abiotic stress. Nevertheless, the relationship between carotenoid biosynthesis and sweet pepper seedlings' resistance to different abiotic stresses remains uncertain.

Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice.

Lactate has emerged as a central metabolic fuel and an important signaling molecule. Its availability participates in various brain functions. Although lactate homeostasis is vital for adult hippocampal neurogenesis and cognition, it is still unknown how shuttles lactate across the plasma membrane of neural stem cells (NSCs) to control their activity and neurogenic potential.

Differentiated Modulating the Electronic Structure of NiFe@Ni/Fe-MnOx via Phase Transformation Engineering to Synergy Promote Bifunctional Water Splitting Reactions.

Modulating electronic structure to balance the requirement of both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is crucial for developing bifunctional catalysts. Herein, phase transformation engineering is utilized to separately regulate catalyst structure, and the designed NiFe@Ni/Fe-MnOOH schottky heterojunction exhibits remarkable bifunctional electrocatalytic activity with low overpotentials of 19 and 230 mV at 10 mA cm for HER and OER in 1M KOH, respectively. Meanwhile, an anion-exchange membrane water electrolyzer employing NiFe@Ni/Fe-MnOOH as electrodes shows low voltages of 1.

Surgical treatment experience of seven cases of Berry syndrome.

Objective: Berry syndrome is a group of rare congenital cardiac malformations including aortopulmonary window (APW), aortic origin of the right pulmonary artery (AORPA), interruption of the aortic arch (IAA), patent ductus arteriosus (PDA) (supplying the descending aorta) and intact ventricular septum. This paper will analyze the clinical data of 7 patients with Berry syndrome who underwent surgical treatment in our institution and discuss the one-stage surgical correction of Berry syndrome in combination with the literature.

Methods: From January 2013 to July 2024, a total of 7 children with Berry syndrome were admitted to the Cardiac Surgery Department of Beijing Children's Hospital.

Combination Therapy with Baricitinib and Narrowband Ultraviolet B for Active Non-Segmental Vitiligo: A Retrospective Controlled Study.

Background: Vitiligo is a chronic autoimmune disease manifested by depigmented patches of skin devoid of melanocytes. Baricitinib, a JAK inhibitor selectively targeting JAK1/2, has shown preliminary efficacy for vitiligo. We aimed to assess the efficacy and tolerability of combination therapy with baricitinib and narrowband UV-B (NB-UVB) to treat active nonsegmental vitiligo (NSV).

Phylogeography of (Apiaceae) From the Sky Islands of Southwest China.

Sky islands provide insights on how glacial-interglacial cycles have shaped species distribution and help for predicting species' responses to climate warming. The alpine subnival belt of southwest China, especially in the Hengduan Mountains and adjacent areas, is sky island-like. Among them, the Yunnan-Kweichow Plateau harbors several isolated mountains with well-developed alpine subnival vegetation, sharing a similar species composition with the Hengduan Mountains.

Landscape of structural variants reveals insights for local adaptations in the Asian corn borer.

Capturing the genetic diversity of different wild populations is crucial for unraveling the mechanisms of adaptation and establishing links between genome evolution and local adaptation. The Asian corn borer (ACB) moth has undergone natural selection during its adaptative evolution. However, structural variants (SVs), which play significant roles in these adaptation processes, have not been previously identified.

Effects of train speed and passenger capacity on the environmental vibration of viaduct and surrounding soil of suburban railways.

Compared with the general urban rail transit, some of the current rapid urban rail transit can reach a maximum speed of 140 km/h when the train is running, which exceeds the speed level of the general urban rail transit. To consider the influence of different speeds and loads on the vibration of viaducts and the surrounding soil environment, this paper establishes a three-dimensional finite element model of rail-viaduct soil. The results show that: the frequency domain acceleration of each measurement point increases with the increase of train speed; except for the measurement point which is 20 m away from the centerline of the track, the frequency domain speed of each measurement point increases with the increase of train speed; the frequency domain speed under the low-frequency component of the viaduct measurement point increases with the increase of train loading, and the growth rate is obviously larger than that of the middle and high frequency bands, and the frequency domain speed of the measurement points in the site also increases with the increase of train loading, and the growth rate of the low-frequency band is obviously larger than that of the middle and high frequency bands.

Research on doctor-patient communication teaching for oncology residents: a new teaching model.

Background: At present, there is no specific teaching method for doctor-patient communication for oncology residents. This study combined BOPPPS (bridge-in, learning objective, pretest, participatory learning, posttest, and summary) teaching model and SBAR (situation-background-assessment-recommendation) communication model to try a new teaching and assessment model of doctor-patient communication, aiming to explore and improve the teaching method of doctor-patient communication for oncology residents.

Methods: Ninety residents were randomly divided into two groups: the experimental group (n = 45) was trained with the BOPPPS teaching model combined with the SBAR communication model, the routine teaching method was adopted in the control group (n = 45).

Rapid Identification of Medicinal Polygonatum Species and Predictive of Polysaccharides Using ATR-FTIR Spectroscopy Combined With Multivariate Analysis.

Introduction: Medicinal Polygonatum species is a widely used traditional Chinese medicine with high nutritional value, known for its anti-fatigue properties, enhancement of immunity, delays aging, improves sleep, and other health benefits. However, the efficacy of different species varies, making the quality control of medicinal Polygonatum species increasingly important. Polysaccharides are important in medicinal Polygonatum species because of their potential functional properties, such as antioxidation, hypoglycemia, protection of intestinal health, and minimal toxicological effects on human health, as well as high polysaccharide levels.

Seasonal changes in hydraulic functions of eight temperate tree species: divergent responses to freeze-thaw cycles in spring and autumn.

Freeze-thaw cycles (FTCs) are the major seasonal environment stress in the temperate and boreal forests, inducing hydraulic dysfunction and limiting tree growth and distribution. There are two types of FTCs in the field: FTCs with increasing temperature from winter to spring (spring FTCs); and FTCs with decreasing temperature from autumn to winter (autumn FTCs). While previous studies have evaluated the hydraulic function during the growing season, its seasonal changes and how it adapts to different types of FTCs remain unverified.

C-FOS inhibition promotes pancreatic cancer cell ferroptosis by transcriptionally regulating the expression of SLC7A11.

Cellular proto-oncogene C-Fos forms the AP-1 transcription factor by dimerizing with proto-oncogene c-Jun; this factor upregulates the transcription of genes associated with different malignancies. However, its functions in pancreatic adenocarcinoma (PAAD) remain poorly understood. In this study, the c-Fos was increased in PAAD cells and tissues through bioinformatic analysis, RT-PCR, and WB.

Mining unique cysteine synthetases and computational study on thoroughly eliminating feedback inhibition through tunnel engineering.

L-cysteine is an essential component in pharmaceutical and agricultural industries, and synthetic biology has made strides in developing new metabolic pathways for its production, particularly in archaea with unique O-phosphoserine sulfhydrylases (OPSS) as key enzymes. In this study, we employed database mining to identify a highly catalytic activity OPSS from Acetobacterium sp. (AsOPSS).

Combining an Enhanced Polyphosphate Kinase-Driven UDP-Glucose Regeneration System with the Screening of Key Glycosyltransferases for Efficient Synthesis of Nucleoside Disaccharides.

Nucleoside disaccharides are essential glycosides that naturally occur in specific living organisms. This study developed an enhanced UDP-glucose regeneration system to facilitate the multienzyme synthesis of nucleoside disaccharides by integrating it with nucleoside-specific glycosyltransferases. The system utilizes maltodextrin and polyphosphate as cost-effective substrates for UDP-glucose supply, catalyzed by α-glucan phosphorylase (αGP) and UDP-glucose pyrophosphorylase (UGP).

Adaptive Navigation Performance Evaluation Method for Civil Aircraft Navigation Systems with Unknown Time-Varying Sensor Noise.

During civil aviation flights, the aircraft needs to accurately monitor the real-time navigation capability and determine whether the onboard navigation system performance meets the required navigation performance (RNP). The airborne flight management system (FMS) uses actual navigation performance (ANP) to quantitatively calculate the uncertainty of aircraft position estimation, and its evaluation accuracy is highly dependent on the position estimation covariance matrix (PECM) provided by the airborne integrated navigation system. This paper proposed an adaptive PECM estimation method based on variational Bayes (VB) to solve the problem of ANP misevaluation, which is caused by the traditional simple ANP model failing to accurately estimate PECM under unknown time-varying noise.

Constructing an artificial in vitro multi-enzyme cascade pathway to convert glycerol and CO into L-aspartic acid.

Developing utilization technologies for biomass resources, exploring their applications in the fields of energy and chemical engineering, holds significant importance for promoting sustainable development and constructing a green, low-carbon society. In this study, we designed a non-natural in vitro multi-enzyme system for converting glycerol and CO into L-aspartic acid (L-Asp). The coupled system utilized eight enzymes, including alditol oxidase (ALDO), catalase-peroxidase (CAT), lactaldehyde dehydrogenase (ALDH), glycerate 2-kinase (GK), phosphopyruvate hydratase (PPH), phosphoenolpyruvate carboxylase (PPC), L-aspartate dehydrogenase (ASPD), and polyphosphate kinase (PPK), to convert the raw materials into L-Asp in one-pot coupled with NADH and ATP regeneration.

How do Chinese and Egyptian science textbooks differ? A cross-country comparative research.

Textbooks have a crucial role in shaping students' knowledge, behaviors, and attitudes in different school subjects. This study compares the structure and content of science textbooks of grade nine in Egypt and China to reveal the common and different features in the textbook design. It opts for a horizontal analysis of four science textbooks in the associated countries.

CTAC Self-Assembled Alkylated β-Cyclodextrin Loaded onto Functionalized MWCNTs Electrochemical Sensor for NP Detection.

Nonylphenol (NP) is an important fine chemical raw material and intermediate that is widely utilized in industry and may be distributed in aquatic ecosystems. Following its entry into the food and water cycles, it can subsequently enter the human body and potentially harm the human reproductive system. For the purpose of monitoring NP in water, it is thus essential to build a straightforward, affordable, and robust electrochemical sensor.

Mandarin fish von Hippel-Lindau protein regulates the NF-κB signaling pathway via interaction with IκB to promote fish ranavirus replication.

The von Hippel-Lindau tumor suppressor protein (VHL), an E3 ubiquitin ligase, functions as a critical regulator of the oxygen-sensing pathway for targeting hypoxia-inducible factors. Recent evidence suggests that mammalian VHL may also be critical to the NF-κB signaling pathway, although the specific molecular mechanisms remain unclear. Herein, the roles of mandarin fish ( ) VHL ( VHL) in the NF-κB signaling pathway and mandarin fish ranavirus (MRV) replication were explored.