The pharmacokinetics, pharmacodynamics, immunogenicity, and safety of osocimab single doses in healthy Chinese and Japanese volunteers over 149 days were evaluated. Two phase 1 single-blinded, placebo-controlled studies with 27 Japanese and 50 Chinese participants were conducted. Osocimab was investigated with IV doses of 0.
View Article and Find Full Text PDFAdvanced building facades, which include windows, walls, and roofs, hold great promise for reducing building energy consumption. In recent decades, the management of heat transfer via electromagnetic radiation between buildings and outdoor environments has emerged as a critical research field aimed at regulating solar irradiation and thermal emission properties. Rapid advancements have led to the widespread utilization of advanced micro/nanofabrication techniques.
View Article and Find Full Text PDFPeriodontitis is a highly prevalent disease characterized by inflammation and destruction of tooth-supporting tissues that leads to tooth loss in extreme situations. Elucidating the underlying mechanisms of periodontitis pathogenesis and progression will establish the groundwork for developing effective treatment strategies. Recently, evidence concerning the role of ferroptosis in periodontitis progression has emerged.
View Article and Find Full Text PDFOral inflammatory diseases (OIDs) include many common diseases such as periodontitis and pulpitis. The causes of OIDs consist microorganism, trauma, occlusal factors, autoimmune dis-eases and radiation therapy. When treated unproperly, such diseases not only affect oral health but also pose threat to people's overall health condition.
View Article and Find Full Text PDFDue to its inversion-broken triple helix structure and the nature of Weyl semiconductor, 2D Tellurene (2D Te) is promising to possess a strong nonlinear optical response in the infrared region, which is rarely reported in 2D materials. Here, a giant nonlinear infrared response induced by large Berry curvature dipole (BCD) is demonstrated in the Weyl semiconductor 2D Te. Ultrahigh second-harmonic generation response is acquired from 2D Te with a large second-order nonlinear optical susceptibility (χ ), which is up to 23.
View Article and Find Full Text PDFThe energy efficiency of buildings has become a critical issue due to their substantial contribution to global energy consumption. Windows, in particular, are often the least efficient component of the building envelope, and conventional smart windows focus solely on regulating solar transmittance while overlooking radiative cooling. Although several recent designs achieved dual-control of solar and radiative cooling, these windows still face limitations in terms of durability, limited modulation ability and energy-saving performance.
View Article and Find Full Text PDFSpin-orbit torque (SOT)-induced switching of perpendicular magnetization in the absence of magnetic field is crucial for the application of SOT-based spintronic devices. Recent works have demonstrated that the low-symmetry crystal structure in CuPt/CoPt can give rise to an out-of-plane (OOP) spin torque and lead to deterministic magnetization switching without an external field. However, it is essential to improve OOP effective field for the efficient switching.
View Article and Find Full Text PDFAll-electric switching of perpendicular magnetization is a prerequisite for the integration of fast, high-density, and low-power magnetic memories and magnetic logic devices into electric circuits. To date, the field-free spin-orbit torque (SOT) switching of perpendicular magnetization has been observed in SOT bilayer and trilayer systems through various asymmetric designs, which mainly aim to break the mirror symmetry. Here, we report that the perpendicular magnetization of CoPt single layers within a special composition range (20 < x < 56) can be deterministically switched by electrical current in the absence of external magnetic field.
View Article and Find Full Text PDFJ Tissue Eng Regen Med
September 2022
Orofacial mesenchymal stromal cells (OFMSCs) are mesenchymal stromal cells isolated from the oral and facial regions, which possess typical mesenchymal stromal cell features such as self-renewing, multilineage differentiation, and immunoregulatory properties. Recently, increasing studies have been carried out on the neurotrophic and neuroregenerative properties of OFMSCs as well as their potential to treat neurological diseases. In this review, we summarize the current evidence and discuss the prospects regarding the therapeutic potential of OFMSCs as a new approach to treat different neurological diseases and injuries.
View Article and Find Full Text PDFTungsten disulfide (WS) is well known to have great potential as an electrocatalyst, but the practical application is hampered by its intrinsic inert plane and semiconductor properties. In this work, owing to a Co-based zeolite imidazole framework (ZIF-67) that effectively inhibited WS growth, few-layered WS was confined to the surface of Co, N-doped carbon polyhedron (WS@CoS), with more marginal active sites and higher conductivity, which promoted efficient oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). For the first time, WS@CoS was prepared by mixing in one pot of a liquid phase and calcination, and WS realized uniform distribution on the polyhedron surface by electrostatic adsorption in the liquid phase.
View Article and Find Full Text PDFThe recent COVID-19 virus has led to a rising interest in antimicrobial and antiviral coatings for frequently touched surfaces in public and healthcare settings. Such coatings may have the ability to kill a variety of microorganisms and bio-structures and reduce the risk of virus transmission. This paper proposes an extremely rapid method to introduce rare-earth doping nano-ZnO in polyamines for the preparation of the anti-microbial polyurea coatings.
View Article and Find Full Text PDFImproving the efficiencies of organic compound degradations by catalytic materials is a challenging materials research field. In our research, we successfully synthesized cobalt-based polyoxometalates (CoV-POMs) via a simple crystallization-driven self-assembly method. The incorporation of the newly synthesized CoV-POMs into peroxymonosulphate (PMS), forming a mixture, greatly enhancing the catalytic activation for a complete degradation of dye solution.
View Article and Find Full Text PDFTwo-dimensional (2D) nanomaterials (NM) have emerged as promising platforms for antibacterial applications. However, the inherent "flatness" of 2D NM often limits the loading of antimicrobial components needed for synergistic bactericidal actions. Here, inspired by the highly ornamented siliceous frustules of diatoms, we prepared 2D ultrathin (<20 nm) and rigid "nanofrustule" plates the out-of-plane growth of cetyltrimethylammonium bromide (CTAB) directed silica mesostructures on the surfaces of 2D graphene oxide nanosheets.
View Article and Find Full Text PDFThe formation of biofilms on medical-context surfaces gives the EPS embedded bacterial community protection and additional advantages that planktonic cells would not have such as increased antibiotic resistance and horizontal gene transfer. Bacterial cells tend to attach to a conditioning layer after overcoming possible electrical barriers and go through two phases of attachments: reversible and irreversible. In the first, bacterial attachment to the surface is reversible and occurs quickly whilst the latter is permanent and takes place over a longer period of time.
View Article and Find Full Text PDF3D printing of transparent ceramics has attracted great attention recently but faces the challenges of low transparency and low printing resolution. Herein, magnesium aluminate spinel transparent ceramics with transmittance reaching 97% of the theoretical limit are successfully fabricated using a stereolithography-based 3D printing method assisted by hot isostatic pressing and the critical factors governing the transparency are revealed. Various transparent spinel lenses and microlattices are printed at a high resolution of ≈100-200 µm.
View Article and Find Full Text PDFMaterials (Basel)
January 2021
Highly transparent YO ceramics were successfully fabricated with CaO as sintering aid. The microstructure evolution, optical transmittance, hardness and thermal conductivity of the YO ceramics were investigated. It was found that doping a small amount (0.
View Article and Find Full Text PDFMarine structures often suffer from biofouling, which may lead to macrofouling by marine animals like marine worms and barnacles, weighing down the structures and increasing the drag. This paper analyses the effect of the newly fabricated biological anti-adhesion Titania-Polyurea spray coating, which can effectively reduce biofouling from enriching on the surface. Through the surface characterization, bioassays and micro-channel drag-reduction test, the antibacterial effect caused by the nano-titanium dioxide is systematically studied.
View Article and Find Full Text PDFTransition-metal-doped tungsten semicarbide nanosheets (M-doped WC NSs, M=Fe, Co, and Ni) have been synthesized through carburization of the mixture of tungsten trioxide, polyvinylpyrrolidone, and metal dopant. The nanosheets grow directly on the W mesh and have the lateral dimension of several hundreds of nm to a few m with a thickness of few tens nm. It is demonstrated that the M-doped WC NSs exhibit superior electrocatalytic activity for hydrogen evolution reaction (HER).
View Article and Find Full Text PDFHere, we report the use of LiMn(SO) as a potential energy storage material and describe its route of synthesis and structural characterization over one electrochemical cycle. LiMn(SO) is synthesized by ball milling of MnSO·HO and LiSO·HO and characterized using a suite of techniques, in particular, ex situ X-ray diffraction, X-ray photoelectron spectroscopy, and X-ray absorption spectroscopy on the Mn and S K-edges to investigate the electronic and local geometry around the absorbing atoms. The prepared LiMn(SO) electrodes undergo electrochemical cycles to different potential points on the charge-discharge curve and are then extracted from the cells at these points for ex situ structural analysis.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
June 2019
Municipal solid waste incineration (MSWI) generates bottom ash, fly ash (FA), and air pollution control (APC) residues as by-products. FA and APC residues are considered hazardous due to the presence of soluble salts and a high concentration of heavy metals, and they should be appropriately treated before disposal. Physicochemical characterization using inductively coupled plasma mass spectroscopy (ICP-MS), X-ray diffraction (XRD), and X-ray fluorescence (XRF) have shown that FA and APC have potential for reuse after treatment as these contain CaO, SiO, and AlO.
View Article and Find Full Text PDFACS Appl Mater Interfaces
May 2019
Achieving controllable coherent and incoherent light sources is crucial to meet the requests of the constantly developing integrated optics, which, however, remains challenging for the existing semiconductor materials and techniques. All-inorganic lead halide perovskites (ILHPs) are emerging as the promising semiconductors, featuring the defect-tolerant nature and tunable band gap. Herein, an experimental design, based on the interaction between ILHPs and energetic ions, for achieving controllable light emitters and microlasers is reported.
View Article and Find Full Text PDFComplex oxide thin-film heterostructures often exhibit magnetic properties different from those known for bulk constituents. This is due to the altered local structural and electronic environment at the interfaces, which affects the exchange coupling and magnetic ordering. The emergent magnetism at oxide interfaces can be controlled by ferroelectric polarization and has a strong effect on spin-dependent transport properties of oxide heterostructures, including magnetic and ferroelectric tunnel junctions.
View Article and Find Full Text PDFFor the last decades, the chemical reduction of Au to Au has been widely employed to produce various gold nanostructures. In comparison with the fast reduction, the slow reduction is systematically investigated in this research to provide more insights to reveal intermediary process and further disclose the underlying mechanism for growing gold nanostructures by using a series of simple ligands with aldehyde groups as weak reducing agents. The different binding energies of ligands to Au (n=3, 1 and 0) exhibit variable binding affinities in starting, intermediate, and final gold species.
View Article and Find Full Text PDFCatalyst deactivation is a persistent problem not only for the scientific community but also in industry. Isolated single-site heterogeneous catalysts have shown great promise to overcome these problems. Here, a versatile anchoring strategy for molecular complex immobilization on a broad range of semiconducting or insulating metal oxide ( e.
View Article and Find Full Text PDFA surface-active BiFeO nanoplates (BF-nP) was prepared using a facile hydrothermal protocol for sulfamethoxazole (SMX) removal via peroxymonosulfate (PMS). The catalytic activity of BF-nP was superior to other catalysts with the following order of performance: BF-nP>BiFeO (nanocubes)>>CoO>FeO (low temperature co-precipitation method)>FeO (hydrothermal method)∼BiO∼Bi∼Fe. The empirical relationship of the apparent rate constant (k), BF-nP loading and PMS dosage can be described as follows: k=0.
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